Shh^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Shh^tm1Amc
• Name: sonic hedgehog; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:1934261
• Synonyms: Shh-, Shhⁿ
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50050
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance gene cassette replaced exon 2 and portions of the flanking intronic sequences. (J:50050)

Disease models

Expression

In Mice Carrying this Mutation:	312 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	59 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 45 strains or lines available

References

• Original: J:50050 St-Jacques B, et al., Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998 Sep 24;8(19):1058-68
• All: 75 reference(s)