Phenotypes Associated with This Genotype

Genotype
MGI:5495972

cn5

• Allelic Composition: Palb2^tm1.1Dli/Palb2^tm1.1Dli; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mouth tumor incidence ( J:197442 )

• in the oral mucosa

increased mammary gland tumor incidence ( J:197442 )

increased skin tumor incidence ( J:197442 )

abnormal tumor morphology ( J:197442 )

• expanded spectrum of tissues affected by tumors compared to in Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)1Amc mice

decreased tumor latency ( J:197442 )

• mice develop mammary tumor faster than Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)1Amc mice

integument

increased mammary gland tumor incidence ( J:197442 )

increased skin tumor incidence ( J:197442 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:197442 )

craniofacial

increased mouth tumor incidence ( J:197442 )

• in the oral mucosa

growth/size/body

increased mouth tumor incidence ( J:197442 )

• in the oral mucosa