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Phenotypes Associated with This Genotype
Genotype
MGI:5316468
cn11
Allelic
Composition
Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(KRT14-cre)1Amc/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-YAP1*)Fcam mutation (0 available); any Col1a1 mutation (165 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1034 available)
Tg(KRT14-cre)1Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• skin grafts on nude mice treated with doxycycline exhibit stunted hair growth unlike control grafts
• doxycycline-treated mice exhibit multi-layered epithelium unlike control mice
• skin grafts on nude mice treated with doxycycline exhibit hyperkeratosis unlike control grafts
• skin grafts on nude mice treated with doxycycline exhibit hyperkeratosis unlike control grafts
• 8 days after doxycycline treatment
• 8 days after doxycycline treatment
• skin from doxycycline-treated mice exhibit a greater than 5-fold increase in the number of colony-forming cells compared with skin from control mice
• in nude mice receiving skin grafts and treated with doxycycline

craniofacial
• thickened and dysplastic in doxycycline-treated mice

neoplasm
• in nude mice receiving skin grafts and treated with doxycycline

cellular
• doxycycline-treated mice exhibit increased cell proliferation of basal cells and an extension of the proliferative domain into the suprabasal layers of back skin compared with control mice

digestive/alimentary system
• thickened and dysplastic in doxycycline-treated mice

growth/size/body
• thickened and dysplastic in doxycycline-treated mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/07/2025
MGI 6.24
The Jackson Laboratory