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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ighg1
immunoglobulin heavy constant gamma 1 (G1m marker)
MGI:96446
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl 		decreased germinal center B cell number J:190943
normal immune system phenotype J:190943
Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		normal immune system phenotype J:199122
increased germinal center B cell number J:199122
increased spleen germinal center number J:199122
increased spleen germinal center size J:199122
normal neoplasm J:199122
Ebf1tm1.1Rug/Ebf1tm1.1Rug
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		decreased germinal center B cell number J:182210
Ezh2tm1Tara/Ezh2tm1Tara
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd 		decreased B cell proliferation J:199122
decreased germinal center B cell number J:199122
decreased IgG1 level J:199122
decreased IgG2b level J:199122
decreased IgG3 level J:199122
decreased spleen germinal center number J:199122
decreased spleen germinal center size J:199122
normal immune system phenotype J:199122
Fcer2atm1Max/Fcer2atm1Max
Ighg1tm1.1Pyu/Ighg1+
involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J 		decreased body temperature J:198154
decreased IgG1 level J:198154
decreased IgG2c level J:198154
decreased IgG level J:198154
increased IgE level J:198154
increased IgG2a level J:198154
increased susceptibility to type I hypersensitivity reaction J:198154
increased susceptibility to xenobiotic induced morbidity/mortality J:198154
Fcer2atm1Max/Fcer2atm1Max
Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J 		abnormal immunoglobulin level J:198154
decreased body temperature J:198154
decreased IgG2c level J:198154
decreased IgG level J:198154
increased IgE level J:198154
increased IgG2a level J:198154
increased susceptibility to type I hypersensitivity reaction J:198154
increased susceptibility to xenobiotic induced morbidity/mortality J:198154
Gm614tm1.1Cya/Gm614tm1.1Cya
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N 		decreased susceptibility to systemic lupus erythematosus J:307345
normal immune system phenotype J:307345
increased B cell apoptosis J:307345
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
Prdm1tm2Masu/Prdm1tm2Masu
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal germinal center B cell physiology J:167612
abnormal plasma cell differentiation J:167612
decreased IgG1 level J:167612
decreased survivor rate J:167612
enlarged liver J:167612
enlarged lymph nodes J:167612
enlarged spleen J:167612
increased B cell derived lymphoma incidence J:167612
increased germinal center B cell number J:167612
premature death J:167612
Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6) 		abnormal class switch recombination J:172031
absent spleen germinal center J:172031
decreased B cell number J:172031
decreased follicular B cell number J:172031
decreased germinal center B cell number J:172031
decreased IgA level J:172031
decreased IgG1 level J:172031
decreased IgG2a level J:172031
decreased IgG2b level J:172031
decreased IgG3 level J:172031
decreased plasma cell number J:172031
decreased tumor-free survival time J:172031
enlarged spleen J:172031
increased B cell number J:172031
increased histiocytic sarcoma incidence J:172031
increased IgE level J:172031
increased macrophage cell number J:172031
increased marginal zone B cell number J:172031
increased sarcoma incidence J:172031
increased spleen weight J:172031
increased tumor incidence J:172031
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal spleen morphology J:167612
decreased germinal center B cell number J:167612
enlarged spleen J:167612
increased B cell number J:167612
increased IgG1 level J:167612
increased IgM level J:167612
increased plasma cell number J:167612
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
Prdm1tm2Masu/Prdm1tm2Masu
involves: 129P2/OlaHsd * C57BL/6 		abnormal germinal center B cell physiology J:167612
abnormal plasma cell differentiation J:167612
decreased IgG1 level J:167612
decreased survivor rate J:167612
increased B cell derived lymphoma incidence J:167612
increased germinal center B cell number J:167612
premature death J:167612
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:191824
increased B cell derived lymphoma incidence J:191824
increased germinal center B cell number J:191824
premature death J:191824
Gt(ROSA)26Sortm12(CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		decreased spleen germinal center size J:188564
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		normal immune system phenotype J:188564
Ighg1tm1(cre)Cgn/Ighg1+
Irf4tm1Rdf/Irf4tm1.1Rdf
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 		abnormal class switch recombination J:112643
abnormal memory B cell morphology J:112643
absent plasma cells J:112643
decreased IgG1 level J:112643
normal immune system phenotype J:112643
Ighg1tm1(cre)Cgn/Ighg1+
Myd88em1.1Rsky/Myd88+
involves: 129P2/OlaHsd * C57BL/6NTac 		abnormal somatic hypermutation frequency J:308792
abnormal splenic cell ratio J:308792
normal hematopoietic system phenotype J:308792
increased germinal center B cell number J:308792
increased IgM level J:308792
increased plasma cell number J:308792
Ighg1tm1(cre)Cgn/Ighg1+
Tbl1xr1tm1c(EUCOMM)Hmgu/Tbl1xr1tm1c(EUCOMM)Hmgu
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell differentiation J:292118
abnormal spleen morphology J:292118
Ighg1tm1(cre)Cgn/Ighg1+
Tbl1xr1tm1.1Meln/Tbl1xr1+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell differentiation J:292118
abnormal spleen morphology J:292118
Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2b+
involves: 129P2/OlaHsd * C57BL/6 		decreased germinal center B cell number J:265465
Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
involves: 129P2/OlaHsd * C57BL/6 		abnormal mature B cell morphology J:265465
decreased germinal center B cell number J:265465
Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Mef2ctm2Eno/Mef2ctm2Eno
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		decreased germinal center B cell number J:265465
Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2b+
involves: 129P2/OlaHsd * C57BL/6 		abnormal mature B cell morphology J:265465
increased germinal center B cell number J:265465
Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2btm1.1Rdf
involves: 129P2/OlaHsd * C57BL/6 		abnormal mature B cell morphology J:265465
increased germinal center B cell number J:265465
Ighg1tm1(cre)Cgn/0
Mef2ctm2Eno/Mef2ctm2Eno
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		decreased germinal center B cell number J:265465
Ighg1tm1(cre)Cgn/0
Mef2dtm3Eno/Mef2dtm3Eno
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		normal hematopoietic system phenotype J:265465
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		increased circulating glucose level J:91865
increased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		insulitis J:91865
Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Ighg1tm1(IGHG1)Rsky/Ighg1tm1(IGHG1)Rsky
involves: 129P2/OlaHsd 		normal immune system phenotype J:127217
Kmt2dtm1.1Kaig/Kmt2d+
Ighg1tm1(cre)Cgn/Ighg1+
Tg(Vav-BCL2)69Jad/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J 		increased B cell derived lymphoma incidence J:228913
increased follicular lymphoma incidence J:228913
premature death J:228913
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:228913
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Ighg1tm1(cre)Cgn/Ighg1+
Tg(Vav-BCL2)69Jad/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J 		increased B cell derived lymphoma incidence J:228913
increased follicular lymphoma incidence J:228913
premature death J:228913
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 		increased germinal center B cell number J:266124
increased T follicular helper cell number J:266124
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		abnormal B cell number J:91865
increased circulating glucose level J:91865
increased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory