Ighg1^{tm1(IGHG1)Rsky}
Targeted Allele Detail

Summary

• Symbol: Ighg1^{tm1(IGHG1)Rsky}
• Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, Klaus Rajewsky
• MGI ID: MGI:3767329
• Gene: Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg1^{tm1(IGHG1)Rsky} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons encoding the secretory form of human IGHG1 and a neo cassette with a 5' loxP site were inserted upstream of exon 1. An additional loxP site was inserted between the exons encoding the secretory and membrane form of the mouse gene. Cre-mediated recombination resulted in the removal of the neo cassette and the secreted mouse form. (J:127217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighg1 Mutation: 30 strains or lines available

References

• Original: J:127217 Zou YR, et al., Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr Biol. 1994 Dec 1;4(12):1099-103
• All: 1 reference(s)