Gm614^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Gm614^tm1.1Cya
• Name: predicted gene 614; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6727377
• Synonyms: Gm614^fl, Gm614^tm1.1Cgen
• Gene: Gm614 Location: ChrX:100304982-100307598 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Gm614^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307345
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted upstream of the gene and a second loxP site into intron 1. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 1 floxed. (J:307345)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gm614 Mutation: 6 strains or lines available

References

• Original: J:307345 He Y, et al., Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice. Front Immunol. 2020;11:585726
• All: 1 reference(s)