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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxo1
forkhead box O1
MGI:1890077
50 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Adipoqtm1Ish/Adipoqtm1Ish
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Tg(Col1a1-cre)1Kry/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N 		normal growth/size/body region phenotype J:199264
normal homeostasis/metabolism phenotype J:199264
normal skeleton phenotype J:199264
Foxo1tm1.1Rdp/Foxo1+
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv 		increased B cell number J:157297
Foxo1tm1Flv/Foxo1tm1Flv
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:189962
normal mortality/aging J:189962
Foxo1tm1Flv/Foxo1tm1Flv
Ifngtm1Ts/Ifngtm1Ts
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ 		normal immune system phenotype J:189962
increased CD4-positive, alpha-beta T cell number J:189962
increased CD8-positive, alpha-beta T cell number J:189962
normal mortality/aging J:189962
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-Il7r)1Asin/?
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2 		decreased T cell number J:147057
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2 		decreased T cell number J:147057
Foxo1tm1Mrc/Foxo1tm1Mrc
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		normal neoplasm J:93444
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal circulating hormone level J:232961
abnormal ovarian follicle morphology J:232961
decreased circulating luteinizing hormone level J:232961
increased circulating estradiol level J:232961
increased granulosa cell tumor incidence J:232961
ovary cyst J:232961
suppressed circulating follicle stimulating hormone level J:232961
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae * 129S6/SvEvTac 		abnormal circulating hormone level J:232961
decreased circulating luteinizing hormone level J:232961
increased granulosa cell tumor incidence J:232961
suppressed circulating follicle stimulating hormone level J:232961
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Tg(CYP19A1-cre)1Jri/0
involves: 129S6/SvEvTac 		abnormal circulating hormone level J:232961
abnormal granulosa cell morphology J:232961
abnormal ovarian follicle morphology J:232961
decreased circulating luteinizing hormone level J:232961
increased circulating estradiol level J:232961
increased granulosa cell tumor incidence J:232961
suppressed circulating follicle stimulating hormone level J:232961
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv 		absent marginal zone B cells J:157297
increased B cell number J:157297
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo3tm1Rdp/Foxo3tm1Rdp
Foxo4tm1Rdp/Foxo4tm1Rdp
Tg(Ins2-cre)23Herr/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J 		abnormal glucose homeostasis J:215526
abnormal mitochondrial physiology J:215526
abnormal pancreatic beta cell differentiation J:215526
abnormal pancreatic beta cell physiology J:215526
decreased circulating insulin level J:215526
decreased insulin secretion J:215526
hyperglycemia J:215526
impaired glucose tolerance J:215526
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo3tm1Rdp/Foxo3tm1Rdp
Foxo4tm1Rdp/Foxo4tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N 		increased hamartoma incidence J:118179
increased hemangioma incidence J:118179
increased hemangiosarcoma incidence J:118179
increased T cell derived lymphoma incidence J:118179
premature death J:118179
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo3tm1Rdp/Foxo3tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N 		abnormal blood vessel morphology J:118179
increased hemangioma incidence J:118179
increased hemangiosarcoma incidence J:118179
increased hepatic hemangioma incidence J:118179
increased tumor incidence J:118179
premature death J:118179
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo4tm1Rdp/Foxo4tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N 		increased hamartoma incidence J:118179
increased hemangioma incidence J:118179
increased hemangiosarcoma incidence J:118179
increased hepatic hemangioma incidence J:118179
premature death J:118179
Foxo1tm1Rdp/Foxo1tm1Rdp
Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB 		abnormal triglyceride level J:137845
decreased circulating cholesterol level J:137845
decreased circulating free fatty acids level J:137845
decreased circulating HDL cholesterol level J:137845
decreased circulating triglyceride level J:137845
normal homeostasis/metabolism phenotype J:137845
Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insr+
involves: 129S4/SvJae * C57BL/6 		normal homeostasis/metabolism phenotype J:79560
Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insrtm1Dac
involves: 129S4/SvJae * C57BL/6 		decreased circulating glucose level J:79560
postnatal lethality J:79560
Foxo1tm1Whb/Foxo1+
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal endocrine/exocrine gland phenotype J:80826
normal homeostasis/metabolism phenotype J:80826
Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0
involves: 129S4/SvJae * C57BL/6J * CBA/J 		abnormal pancreas physiology J:109010
decreased circulating glucose level J:109010
increased circulating insulin level J:109010
increased pancreatic beta cell number J:109010
Foxo1tm2.1Dac/Foxo1tm2.1Dac
Insrtm1Dac/Insr+
involves: 129S4/SvJae * C57BL/6 		increased circulating insulin level J:179687
insulin resistance J:179687
Foxo1tm2.1Dac/Foxo1tm2.1Dac
Leprdb/Leprdb
B6.Cg-Foxo1tm2.1Dac Leprdb 		impaired glucose tolerance J:179687
increased circulating insulin level J:179687
Gt(ROSA)26Sortm1(Foxo1)Jnk/Gt(ROSA)26Sor+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(CAG-cat,-lacZ)11Miya/0
Tg(Pomc1-cre)16Lowl/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N 		increased body weight J:162892
Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(CAG-cat,-lacZ)11Miya/0
Tg(Pomc1-cre)16Lowl/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N 		increased body weight J:162892
increased food intake J:162892
increased total body fat amount J:162892
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory