Foxo1^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Foxo1^tm1Mrc
• Name: forkhead box O1; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:3487370
• Synonyms: Fkhr^F2-3m
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93444
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exons 2 and 3 with Lox511 sites and to insert an FRT flanked cassette containing tACE-Flpe-neo. The FRT flanked cassette was excised upon crossing with transgenic mice expressing FLPe. (J:93444)

Tumor Data

List all tumor models in MMHCdb carrying Foxo1^tm1Mrc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 31 strains or lines available

References

• Original: J:93444 Keller C, et al., Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26
• All: 6 reference(s)