Foxo1^tm1Whb
Targeted Allele Detail

Summary

• Symbol: Foxo1^tm1Whb
• Name: forkhead box O1; targeted mutation 1, William H Biggs III
• MGI ID: MGI:2447732
• Synonyms: Foxo1^-, FoxO1⁺
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^tm1Whb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by a beta-geo cassette inserted immediately downstream of the start codon in exon 1 by homologous recombination. The deleted region included the coding region of exon 1 and approximately 3 kb of intronic sequnence. Transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:79560)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 34 strains or lines available

References

• Original: J:79560 Nakae J, et al., Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002 Oct;32(2):245-53
• All: 11 reference(s)