Lmna
Gene Detail

Symbol Name ID

Lmna lamin A MGI:96794

Synonyms

Dhe, lamin A/C

Feature Type

protein coding gene

Genetic Map

Chromosome 3

38.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:88481148-88509956 bp, - strand From VEGA annotation of GRCm38   28809 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Lmna

Human homologs

Human Homolog		LMNA, lamin A/C
NCBI Gene ID		4000
neXtProt AC		NX_P02545
Human Synonyms		CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Human Chr (Location)		1q22; chr1:156052369-156109880 (+)  GRCh37.p10
Disease Associations		(11) Diseases Associated with Human LMNA

Alleles and phenotypes

All alleles(139) : Targeted(17) Gene trapped(121) Spontaneous(1)
 

Homozygotes for targeted mutations exhibit retarded postnatal growth, muscular dystrophy, reduced fat stores, micrognathy, abnormal dentition, impaired gonadal development, malformed scapulae, and hyperkeratosis, and die by 8 weeks of age.

 
Human Diseases Modeled Using Mouse Lmna (5)    Alleles Annotated to Human Diseases(8)    Phenotype Images(9)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	establishment of cell polarity, establishment or maintenance of microtubule cytoskeleton polarity, ...
Component	cytoplasm, intermediate filament, ...
Function	protein binding, structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (52)    Tissues (3)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	52

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(7) cDNA(23)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000030317 (Evidence)
Ensembl Gene Model	ENSMUSG00000028063 (Evidence)
Entrez Gene	16905 (Evidence)
DFCI	TC1573937, TC1598415, TC1613340, TC1694266, TC1722966
DoTS	DT.101157655, DT.101157660, DT.101157683, DT.101704248, DT.103570708, DT.533491, DT.91571182, DT.94370704
NIA Mouse Gene Index	U024254
PDB	1UFG
Consensus CDS Project	CCDS38482.1, CCDS38483.1, CCDS50951.1
International Mouse Knockout Project Status	Lmna

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030317	VEGA Gene Model | MGI Sequence Detail	28809	C57BL/6J
transcript	OTTMUST00000075092	VEGA | MGI Sequence Detail	3156	Not Applicable
polypeptide	OTTMUSP00000039297	VEGA | MGI Sequence Detail	665	Not Applicable

All sequences(107) RefSeq(6) UniProt(8)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR001322	Lamin Tail Domain
Protein Ontology	PR:000009859	prelamin-A/C

References

(Earliest) J:16565 Riedel W, et al., Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence. Biochim Biophys Acta. 1989 Jun 1;1008(1):119-22
(Latest) J:192877 Zuo B, et al., Influences of lamin A levels on induction of pluripotent stem cells. Biol Open. 2013;1:1118-1127
All references(136)

Other accession IDs

MGD-MRK-11818, MGI:2156104