About   Help   FAQ
Lmna
Gene Detail
 Symbol
Name
ID
Lmna
lamin A
MGI:96794
Synonyms Dhe, lamin A/C
Feature Type protein coding gene
Genetic Map
Chromosome 3
38.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:88481148-88509956 bp, - strand
From VEGA annotation of GRCm38

  28809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Lmna

Human
homologs
Human Homolog LMNA, lamin A/C
NCBI Gene ID 4000
neXtProt AC  NX_P02545
Human Synonyms  CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Human Chr (Location)  1q22; chr1:156082546-156140089 (+)  GRCh38
Disease Associations  (11) Diseases Associated with Human LMNA
Mutations,
alleles, and
phenotypes
All mutations/alleles(142) : Gene trapped(121) Spontaneous(1) Targeted(20)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit retarded postnatal growth, muscular dystrophy, reduced fat stores, micrognathy, abnormal dentition, impaired gonadal development, malformed scapulae, hyperkeratosis, and die by 8 weeks of age.
 
Human Diseases Modeled Using Mouse Lmna (5)    Alleles Annotated to Human Diseases(8)    Phenotype Images(12)
Interactions
Lmna interacts with 144 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process establishment of cell polarity, establishment or maintenance of microtubule cytoskeleton polarity, ...
Component cell, cytoplasm, ...
Function protein binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (52)    Tissues (3)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 52
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(7) cDNA(23)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000030317 (Evidence)
Ensembl Gene ModelENSMUSG00000028063 (Evidence)
Entrez Gene16905 (Evidence)
DFCITC1573937, TC1598415, TC1613340, TC1694266, TC1722966
DoTSDT.101157655, DT.101157660, DT.101157683, DT.101704248, DT.103570708, DT.111057509, DT.533491, DT.91571182, DT.94370704
NIA Mouse Gene IndexU024254
PDB1UFG
Consensus CDS ProjectCCDS38482.1, CCDS38483.1, CCDS50951.1
International Mouse Knockout Project StatusLmna
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030317 VEGA Gene Model | MGI Sequence Detail 28809 C57BL/6J ±  kb
transcript OTTMUST00000075092 VEGA | MGI Sequence Detail 3156 Not Applicable 
polypeptide OTTMUSP00000039297 VEGA | MGI Sequence Detail 665 Not Applicable 

For the selected sequences
All sequences(118) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR001322 Lamin Tail Domain
Protein Ontology PR:000009859 prelamin-A/C
References (Earliest) J:16565 Riedel W, et al., Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence. Biochim Biophys Acta. 1989 Jun 1;1008(1):119-22
(Latest) J:207144 Jung HJ, et al., New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome. Hum Mol Genet. 2014 Mar 15;23(6):1506-15
All references(155)
Disease annotation references (14)
Other
accession IDs
MGD-MRK-11818, MGI:2156104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory