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Phenotypes Associated with This Genotype
Genotype
MGI:5754490
Allelic
Composition		 Lmnatm10Lgf/Lmnatm10Lgf
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm10Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal esophageal squamous epithelium morphology ( J:220988 )
• esophagus shows a cornified squamous epithelium
dilated esophagus ( J:220988 )
• mice develop dilated, yellow esophagus
abnormal colon morphology ( J:220988 )
• dilated proximal colon
esophageal achalasia ( J:220988 )
• thinning and fibrosis of the muscularis externa, pathology similar to achalasia

muscle
esophageal achalasia ( J:220988 )
• thinning and fibrosis of the muscularis externa, pathology similar to achalasia

nervous system
nervous system phenotype ( J:220988 )
N
• mice show no pathology in the central nervous system

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
achalasia DOID:9164 OMIM:200400
 J:220988

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory