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Phenotypes Associated with This Genotype
Genotype
MGI:6423601
Allelic
Composition		 Lmnatm1.1Bliu/Lmna+
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1.1Bliu mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:287256 )
• shortened life span

growth/size/body
postnatal growth retardation ( J:287256 )

cardiovascular system
abnormal vasodilation ( J:287256 )
• acetylcholine-induced thoracic aorta relaxation is compromised

muscle
abnormal vasodilation ( J:287256 )
• acetylcholine-induced thoracic aorta relaxation is compromised

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
 J:287256

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory