Phenotypes Associated with This Genotype

Genotype
MGI:7518590

• Allelic Composition: Lmna^em1Fenz/Lmna⁺
• Genetic Background: C57BL/6-Lmna^em1Fenz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:338760 )

N • normal fat deposits when fed regular chow (RCD)

increased brown adipose tissue mass ( J:338760 )

♂ • after 10 weeks on high-fat diet (HFD)

abnormal inguinal fat pad morphology ( J:338760 )

♂ • smaller and more disorganized adipocytes and increased inflammation and senescence after 10 weeks on high-fat diet (HFD)

increased renal fat pad weight ( J:338760 )

♂ • after 10 weeks on high-fat diet (HFD)

increased abdominal fat pad weight ( J:338760 )

♂ • after 10 weeks on high-fat diet (HFD)

decreased white adipose tissue mass ( J:338760 )

♂ • lower epididymal white adipose tissue (eWAT) mass and smaller adipocytes after 10 weeks on high-fat diet (HFD)

♂ • normal inguinal white adipose tissue (iWAT) mass after 10 weeks on high-fat diet (HFD)

cellular

abnormal respiratory electron transport chain ( J:338760 )

♂ • impaired in liver and inguinal white adipose tissue (iWAT) mitochondria after 23 weeks on high-fat diet (HFD)

growth/size/body

increased body weight ( J:338760 )

♂ • after 10 weeks on high-fat diet (HFD)

♂ • normal food intake when on high-fat diet (HFD)

♂ • normal body weight when fed regular chow (RCD)

homeostasis/metabolism

increased circulating cholesterol level ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

increased circulating LDL cholesterol level ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

increased circulating alanine transaminase level ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

increased circulating alkaline phosphatase level ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

increased circulating aspartate transaminase level ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

impaired glucose tolerance ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

♂ • normal when fed regular chow (RCD)

insulin resistance ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

♂ • normal when fed regular chow (RCD)

increased liver triglyceride level ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

liver/biliary system

increased liver triglyceride level ( J:338760 )

♂ • after 23 weeks on high-fat diet (HFD)

hepatic steatosis ( J:338760 )

♂ • after 10 weeks on high-fat diet (HFD)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:338760