Phenotypes for Lmna Nat10 MGI:7311574 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lmna^tm1.1Otin/Lmna⁺ Nat10^{tm1a(KOMP)Wtsi}/Nat10⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm1.1Otin mutation (0 available); any Lmna mutation (84 available)
Nat10^{tm1a(KOMP)Wtsi} mutation (2 available); any Nat10 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:261974 )

• significantly delayed compared to in Lmna^tm1.1Otin homozygotes

skeleton

kyphosis ( J:261974 )

• significantly delayed compared to in Lmna^tm1.1Otin homozygotes

growth/size/body

decreased body weight ( J:261974 )

• significantly delayed compared to in Lmna^tm1.1Otin homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:261974

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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