Automated description from the Alliance of Genome Resources (Release 7.0.0)
A structural constituent of cytoskeleton. Involved in several processes, including establishment or maintenance of microtubule cytoskeleton polarity; negative regulation of cardiac muscle hypertrophy in response to stress; and protein localization to nucleus. Acts upstream of or within several processes, including negative regulation of apoptotic signaling pathway; protein import into nucleus; and ventricular cardiac muscle cell development. Located in lamin filament and nuclear membrane. Is active in nuclear lamina. Is expressed in several structures, including embryo mesenchyme; epithelium; heart; immune system; and musculature. Used to study several diseases, including Charcot-Marie-Tooth disease type 2B1; achalasia; dilated cardiomyopathy 1A; muscular dystrophy (multiple); and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C).