Ezh2
Gene Detail

Symbol Name ID

Ezh2 enhancer of zeste homolog 2 (Drosophila) MGI:107940

Synonyms

Enx-1, Enx1h, KMT6

Feature Type

protein coding gene

Genetic Map

Chromosome 6

22.92 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:47530274-47595341 bp, - strand From VEGA annotation of GRCm38   65068 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37926  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ezh2

Human homologs

Human Homolog		EZH2, enhancer of zeste homolog 2 (Drosophila)
NCBI Gene ID		2146
neXtProt AC		NX_Q15910
Human Synonyms		ENX1, ENX-1, EZH1, KMT6, KMT6A, WVS2
Human Chr (Location)		7q35-q36; chr7:148504464-148581441 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EZH2

Alleles and phenotypes

All alleles(48) : Targeted(11) Gene trapped(37)
 

Homozygous null mutants die prior to completing gastrulation. A conditional mutant with loss of expression in immune cells survives, but has defects in early B cell development and Igh rearrangement. Conditional loss of maternal protein results in severegrowth retardation of neonates.

 
Human Diseases Modeled Using Mouse Ezh2 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	cerebellar cortex development, chromatin modification, ...
Component	chromosome, cytoplasm, ...
Function	chromatin binding, core promoter binding, ...

External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (261)    Tissues (184)    Images (4)
Theiler Stages: 2, 3, 5, 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	89
RNA in situ	57
Northern blot	1
RT-PCR	101
RNase protection	13

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(2) cDNA(18) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021193 (Evidence)
Ensembl Gene Model	ENSMUSG00000029687 (Evidence)
Entrez Gene	14056 (Evidence)
DFCI	TC1574682, TC1586155, TC1615678
DoTS	DT.101389801, DT.102539627, DT.535194, DT.97372109
NIA Mouse Gene Index	U027262
EC	2.1.1.43
PDB	2QXV
Consensus CDS Project	CCDS20096.1, CCDS51760.1
International Mouse Knockout Project Status	Ezh2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021193	VEGA Gene Model | MGI Sequence Detail	65068	C57BL/6J
transcript	OTTMUST00000050207	VEGA | MGI Sequence Detail	2652	Not Applicable
polypeptide	OTTMUSP00000023406	VEGA | MGI Sequence Detail	746	Not Applicable

All sequences(78) RefSeq(4) UniProt(10)

Polymorphisms

PCR(1) : SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026489	CXC domain
InterPro	IPR001005	SANT/Myb domain
InterPro	IPR001214	SET domain
InterPro	IPR021654	WD repeat binding protein EZH2
Protein Ontology	PR:000007278	histone-lysine N-methyltransferase EZH2

References

(Earliest) J:32835 Hobert O, et al., Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene. Mech Dev. 1996 Apr;55(2):171-84
(Latest) J:195192 Fragola G, et al., Cell reprogramming requires silencing of a core subset of polycomb targets. PLoS Genet. 2013 Feb;9(2):e1003292
All references(123)

Other accession IDs

MGD-MRK-35129, MGD-MRK-36520, MGI:106670