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Phenotypes Associated with This Genotype
Genotype
MGI:6275998
Allelic
Composition		 Ezh2em1Jbn/Ezh2+
Genetic
Background		 C57BL/6J-Ezh2em1Jbn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2em1Jbn mutation (1 available); any Ezh2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:267184 )
• increased heart weight at 8 weeks of age

growth/size/body
increased heart weight ( J:267184 )
• increased heart weight at 8 weeks of age
increased body weight ( J:267184 )
• by 8 weeks of age, body weight is increased in comparison to controls
• increase is more prominent in females
increased growth rate ( J:267184 )
• is observed by 8 weeks of age
increased kidney weight ( J:267184 )
• increased kidney weight at 8 weeks of age
increased spleen weight ( J:267184 )
• increased spleen weight at 8 weeks of age

hematopoietic system
increased spleen weight ( J:267184 )
• increased spleen weight at 8 weeks of age

immune system
increased spleen weight ( J:267184 )
• increased spleen weight at 8 weeks of age

renal/urinary system
increased kidney weight ( J:267184 )
• increased kidney weight at 8 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Weaver syndrome DOID:14731 OMIM:277590
 J:267184

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory