Gstt1 MGI Mouse Gene Detail - MGI:107379 - glutathione S-transferase, theta 1

Symbol

Gstt1
Name

glutathione S-transferase, theta 1
Synonyms

Gstt1-1

Feature Type

protein coding gene
IDs

MGI:107379
NCBI Gene: 14871
Gene Overview

MyGene.info: GSTT1
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:75783813-75798584 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.58 cM, cytoband B5-C1
Mapping Data

5 experiments

SNPs within 2kb

151 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107379	protein coding gene	Chr10:75783813-75798584 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017365	protein coding gene	Chr10:75969411-75987177 (-)
A/J	MGP_AJ_G0017342	protein coding gene	Chr10:73362933-73377593 (-)
AKR/J	MGP_AKRJ_G0017303	protein coding gene	Chr10:75327747-75343978 (-)
BALB/cJ	MGP_BALBcJ_G0017302	protein coding gene	Chr10:73558657-73573266 (-)
C3H/HeJ	MGP_C3HHeJ_G0017126	protein coding gene	Chr10:75366852-75383624 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017760	protein coding gene	Chr10:78657014-78673090 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015450	protein coding gene	Chr10:69817238-69831510 (-)
CAST/EiJ	MGP_CASTEiJ_G0016697	protein coding gene	Chr10:75687494-75704510 (-)
CBA/J	MGP_CBAJ_G0017098	protein coding gene	Chr10:81725153-81742548 (-)
DBA/2J	MGP_DBA2J_G0017203	protein coding gene	Chr10:72664629-72679649 (-)
FVB/NJ	MGP_FVBNJ_G0017196	protein coding gene	Chr10:71813090-71830171 (-)
LP/J	MGP_LPJ_G0017276	protein coding gene	Chr10:76475386-76491710 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017224	protein coding gene	Chr10:83818525-83835564 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017799	protein coding gene	Chr10:75360771-75376610 (-)
PWK/PhJ	MGP_PWKPhJ_G0016480	protein coding gene	Chr10:72490578-72505500 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016263	protein coding gene	Chr10:74600995-74621761 (-)
WSB/EiJ	MGP_WSBEiJ_G0016760	protein coding gene	Chr10:75333192-75362261 (-)

Human Ortholog

GSTT1, glutathione S-transferase theta 1

Vertebrate Orthologs

6

Human Ortholog

GSTT1, glutathione S-transferase theta 1
Orthology source: HGNC
Links

HGNC:4641

NCBI Gene ID: 2952

neXtProt AC: NX_P30711

UniProt: P30711
Chr Location

22q11.23

HomoloGene

Vertebrate Homology Class 134739
1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: GSTT1
Gene Tree

Gstt1

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Gstt1
Incidental Mutations

APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mis homozygous for disruption of this gene appear to be normal and fertile with the exception of a reduced ability to clear 11,2-bis(2-chloroethyl)-1-nitrosourea from the plasma after a single i.p. dose.

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All GO Annotations

17
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

95
Tissues

95
cDNA Data

67
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gstt1

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Gstt1 interacts with 46 markers (Mir129-1, Mir129-2, Mir153, ...) View All

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All Sequences

47
RefSeq

6
UniProt

4
CCDS

CCDS23932.1
UniGene

2746

Ensembl

ENSMUSG00000001663 (Evidence)
NCBI Gene

14871

			Length	Strain/Species	Flank
genomic	14871	NCBI Gene Model \| MGI Sequence Detail	14772	C57BL/6J	± kb
transcript	NM_008185	RefSeq \| MGI Sequence Detail	1049	C57BL/6
polypeptide	Q64471	UniProt \| EBI \| MGI Sequence Detail	240	Not Applicable

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UniProt

4 Sequences
EC

2.5.1.18
InterPro Domains

IPR004046 Glutathione S-transferase, C-terminal

IPR036282 Glutathione S-transferase, C-terminal domain superfamily

IPR010987 Glutathione S-transferase, C-terminal-like

IPR004045 Glutathione S-transferase, N-terminal

IPR036249 Thioredoxin-like superfamily

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All nucleic 85

Genomic 16

cDNA 67

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-35846, MGI:2143546

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Gstt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98130	Chr10:75798576-75798587 (-)	2 bp
Tssr98129	Chr10:75798517-75798553 (-)	49 bp
Tssr98128	Chr10:75797760-75797776 (-)	816 bp
Tssr98127	Chr10:75797728-75797757 (-)	841 bp
Tssr98126	Chr10:75797528-75797536 (-)	1,052 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/13/2018 MGI 6.13