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Gstt1 Gene Detail
Summary
  • Symbol
    Gstt1
  • Name
    glutathione S-transferase, theta 1
  • Synonyms
    Gstt1-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107379
    NCBI Gene: 14871
  • Gene Overview
    MyGene.info: GSTT1
Location & Maps
more
  • Sequence Map
    Chr10:75783813-75798584 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      14772 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.58 cM, cytoband B5-C1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GSTT1, glutathione S-transferase theta 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GSTT1, glutathione S-transferase theta 1
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 2952
    neXtProt AC: NX_P30711
    UniProt: P30711

  • Chr Location
    22q11.23
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    5
  • Genomic Mutations
    1 involving Gstt1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    7 strains or lines available
Mis homozygous for disruption of this gene appear to be normal and fertile with the exception of a reduced ability to clear 11,2-bis(2-chloroethyl)-1-nitrosourea from the plasma after a single i.p. dose.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    95
  • Tissues
    95
  • cDNA Data
    66
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026319 VEGA Gene Model | MGI Sequence Detail 14772 C57BL/6J ±  kb
transcript OTTMUST00000065097 VEGA | MGI Sequence Detail 1037 Not Applicable  
polypeptide OTTMUSP00000032399 VEGA | MGI Sequence Detail 240 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    151 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • EC
    2.5.1.18
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
less
  • All nucleic 84
    Genomic 16
    cDNA 66
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35846, MGI:2143546
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory