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Tnf Gene Detail
Summary
  • Symbol
    Tnf
  • Name
    tumor necrosis factor
  • Synonyms
    DIF, Tnfa, TNFalpha, TNF alpha, TNF-alpha, Tnfsf1a, tumor necrosis factor-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104798
    NCBI Gene: 21926
  • Gene Overview
    MyGene.info: TNF
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35199381-35202007 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    50 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104798
protein coding gene Chr17:35199367-35202007 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023628
protein coding gene Chr17:35348086-35351882 (-)
A/J MGP_AJ_G0023587
protein coding gene Chr17:34169720-34172348 (-)
AKR/J MGP_AKRJ_G0023556
protein coding gene Chr17:34650677-34653306 (-)
BALB/cJ MGP_BALBcJ_G0023594
protein coding gene Chr17:34313994-34316622 (-)
C3H/HeJ MGP_C3HHeJ_G0023355
protein coding gene Chr17:35056009-35058638 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024033
protein coding gene Chr17:36693785-36696411 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021514
protein coding gene Chr17:31941242-31943883 (-)
CAST/EiJ MGP_CASTEiJ_G0022851
protein coding gene Chr17:35058033-35060661 (-)
CBA/J MGP_CBAJ_G0023333
protein coding gene Chr17:38206494-38209123 (-)
DBA/2J MGP_DBA2J_G0023461
protein coding gene Chr17:33497062-33499690 (-)
FVB/NJ MGP_FVBNJ_G0023428
protein coding gene Chr17:33338751-33341383 (-)
LP/J MGP_LPJ_G0023538
protein coding gene Chr17:35677968-35680594 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023450
protein coding gene Chr17:37134689-37137315 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024078
protein coding gene Chr17:34879278-34881913 (-)
PWK/PhJ MGP_PWKPhJ_G0022599
protein coding gene Chr17:32334333-32336960 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022419
protein coding gene Chr17:32886439-32889072 (-)
WSB/EiJ MGP_WSBEiJ_G0022915
protein coding gene Chr17:35002467-35005095 (-)



Homology
more
  • Human Ortholog
    TNF, tumor necrosis factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNF, tumor necrosis factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIF, TNFA, TNF-alpha, TNFSF2, TNLG1F
  • Links
    NCBI Gene ID: 7124
    neXtProt AC: NX_P01375
    UniProt: P01375

  • Chr Location
    6p21.33; chr6:31575567-31578336 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    8 with Tnf mouse models; 3 with human TNF associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 2 models
IDs
View 1 model
IDs
View 1 model
IDs
View 4 models
IDs
View 4 models
IDs
View 6 models
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    12 with disease annotations
  • References
    13 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    264 phenotypes from 26 alleles in 45 genetic backgrounds
    121 phenotypes from multigenic genotypes
    1 images
    786 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024401 Ensembl Gene Model | MGI Sequence Detail 2627 C57BL/6J ±  kb
    transcript ENSMUST00000025263 Ensembl | MGI Sequence Detail 1639 Not Applicable  
    polypeptide ENSMUSP00000025263 Ensembl | MGI Sequence Detail 235 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 53
      cDNA 24
      Primer pair 15
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15151, MGD-MRK-28090
    References
    more
    • Summaries
      All 1846
      Developmental Gene Expression 73
      Diseases 13
      Gene Ontology 92
      Phenotypes 786
    • Earliest
      J:7045 Rinchik EM, et al., Genetic analysis of the T-H-2 region in non-t chromosomes. I. Two new congenic strains isolate Qglo-1 from H-2. Immunogenetics. 1983;17(5):445-55
    • Latest
      J:266141 Jhan MK, et al., Anti-TNF-alpha restricts dengue virus-induced neuropathy. J Leukoc Biol. 2018 Nov;104(5):961-968

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory