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Tnf
Gene Detail
Symbol

Name
ID
Tnf
tumor necrosis factor
MGI:104798
Synonyms
DIF, Tnfa, TNFalpha, TNF alpha, TNF-alpha, Tnfsf1a, tumor necrosis factor-alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(50)
Sequence Map
Chr17:35199381-35202007 bp, - strand
From VEGA annotation of GRCm38

  2627 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: TNF
Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Tnf

Human
homologs
TNF, tumor necrosis factor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7124
neXtProt AC: NX_P01375

Human Synonyms: DIF, TNFA, TNF-alpha, TNFSF2

Human Chr (Location): 6p21.3; chr6:31575567-31578336 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human TNF

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Chemically induced (ENU)(2) Spontaneous(2) Targeted(20) Transgenic(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects.
 
Human Diseases Modeled in Mice Using Tnf (2)    Mutations Annotated to Human Diseases (4)    Phenotype Images(1)
Interactions
Tnf interacts with 161 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (52 records)
Data Summary: Results (192)    Tissues (94)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
Northern blot 9
RT-PCR 180
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tnf ; ZFIN tnfa, tnfb    NEW 
Molecular
reagents
All nucleic(92) Genomic(53) cDNA(23) Primer pair(15) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037196 (Evidence)
Ensembl Gene Model ENSMUSG00000024401 (Evidence)
Entrez Gene 21926 (Evidence)
UniGene 1293
DFCI TC1579092, TC1596992
DoTS DT.101211936, DT.99859169
NIA Mouse Gene Index U037744
PDB 2TNF
Consensus CDS Project CCDS28691.1, CCDS70801.1
International Mouse Phenotyping Consortium Status Tnf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037196 VEGA Gene Model | MGI Sequence Detail 2627 C57BL/6J ±  kb
transcript OTTMUST00000095888 VEGA | MGI Sequence Detail 1639 Not Applicable 
polypeptide OTTMUSP00000053529 VEGA | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(4)
Polymorphisms
All PCR and RFLP(22) : PCR(10) RFLP(12) SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006053 Tumour necrosis factor
InterPro IPR002959 Tumour necrosis factor alpha
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR006052 Tumour necrosis factor domain
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000000134 tumor necrosis factor alpha
References
(Earliest) J:7045 Rinchik EM, et al., Genetic analysis of the T-H-2 region in non-t chromosomes. I. Two new congenic strains isolate Qglo-1 from H-2. Immunogenetics. 1983;17(5):445-55
(Latest) J:222932 Bertrand F, et al., Blocking Tumor Necrosis Factor alpha Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma. Cancer Res. 2015 Jul 1;75(13):2619-28
All references(1290)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15151, MGD-MRK-28090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory