Tnf
Gene Detail

Symbol Name ID

Tnf tumor necrosis factor MGI:104798

Synonyms

DIF, Tnfa, TNFalpha, TNF alpha, TNF-alpha, Tnfsf1a, tumor necrosis factor-alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(52)

Sequence Map

Chr17:35199381-35202007 bp, - strand From VEGA annotation of GRCm38   2627 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Tnf

Human homologs

Human Homolog		TNF, tumor necrosis factor
NCBI Gene ID		7124
neXtProt AC		NX_P01375
Human Synonyms		DIF, TNFA, TNF-alpha, TNFSF2
Human Chr (Location)		6p21.3; chr6:31543344-31546113 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human TNF

Alleles and phenotypes

All alleles(23) : Targeted(20) Spontaneous(2) Chemically induced(1)
 

Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects.

 
Human Diseases Modeled Using Mouse Tnf (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (168 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of MAPK activity, ...
Component	cell surface, external side of plasma membrane, ...
Function	cytokine activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (47 records)
Data Summary: Results (188)    Tissues (89)    Images (4)
Theiler Stages: 13, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
Northern blot	9
RT-PCR	176

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(91) Genomic(53) cDNA(23) Primer pair(14) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037196 (Evidence)
Ensembl Gene Model	ENSMUSG00000024401 (Evidence)
Entrez Gene	21926 (Evidence)
UniGene	1293
DFCI	TC1579092, TC1596992
DoTS	DT.101211936, DT.99859169
NIA Mouse Gene Index	U037744
PDB	2TNF
Consensus CDS Project	CCDS28691.1
International Mouse Knockout Project Status	Tnf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037196	VEGA Gene Model | MGI Sequence Detail	2627	C57BL/6J
transcript	OTTMUST00000095888	VEGA | MGI Sequence Detail	1639	Not Applicable
polypeptide	OTTMUSP00000053529	VEGA | MGI Sequence Detail	235	Not Applicable

All sequences(44) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(22) : PCR(10) RFLP(12) SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR006053	Tumour necrosis factor alpha/beta/c
InterPro	IPR002959	Tumour necrosis factor alpha/cachectin
InterPro	IPR021184	Tumour necrosis factor, conserved site
InterPro	IPR008983	Tumour necrosis factor-like
Protein Ontology	PR:000000134	tumor necrosis factor alpha

References

(Earliest) J:7045 Rinchik EM, et al., Genetic analysis of the T-H-2 region in non-t chromosomes. I. Two new congenic strains isolate Qglo-1 from H-2. Immunogenetics. 1983;17(5):445-55
(Latest) J:193689 Takasuga S, et al., Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
All references(1180)

Other accession IDs

MGD-MRK-15151, MGD-MRK-28090