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Gene Detail
tumor necrosis factor
Synonyms DIF, Tnfa, TNFalpha, TNF alpha, TNF-alpha, Tnfsf1a, tumor necrosis factor-alpha
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.59 cM
Detailed Genetic Map ± 1 cM

Mapping data(50)
Sequence Map
Chr17:35199381-35202007 bp, - strand
From VEGA annotation of GRCm38

  2627 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Tnf

Human Homolog TNF, tumor necrosis factor
NCBI Gene ID 7124
neXtProt AC  NX_P01375
Human Synonyms  DIF, TNFA, TNF-alpha, TNFSF2
Human Chr (Location)  6p21.3; chr6:31575567-31578336 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human TNF
alleles, and
All mutations/alleles(23) : Chemically induced (ENU)(1) Spontaneous(2) Targeted(20)
Incidental mutations (data from Mutagenetix , APF )
Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects.
Human Diseases Modeled Using Mouse Tnf (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Tnf interacts with 161 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (179 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of MAPK activity, ...
Component cell surface, external side of plasma membrane, ...
Function cytokine activity, identical protein binding, ...
External Resources: FuncBase
Literature Summary: (49 records)
Data Summary: Results (192)    Tissues (94)    Images (4)
Theiler Stages: 13, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
Northern blot 9
RT-PCR 180
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(92) Genomic(53) cDNA(23) Primer pair(15) Other(1)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000037196 (Evidence)
Ensembl Gene ModelENSMUSG00000024401 (Evidence)
Entrez Gene21926 (Evidence)
DFCITC1579092, TC1596992
DoTSDT.101211936, DT.99859169
NIA Mouse Gene IndexU037744
Consensus CDS ProjectCCDS28691.1, CCDS70801.1
International Mouse Knockout Project StatusTnf
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037196 VEGA Gene Model | MGI Sequence Detail 2627 C57BL/6J ±  kb
transcript OTTMUST00000095888 VEGA | MGI Sequence Detail 1639 Not Applicable 
polypeptide OTTMUSP00000053529 VEGA | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(4)
Polymorphisms All PCR and RFLP(22) : PCR(10) RFLP(12) SNPs within 2kb(70 from dbSNP Build 137)
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR002959 Tumour necrosis factor alpha/cachectin
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000000134 tumor necrosis factor alpha
References (Earliest) J:7045 Rinchik EM, et al., Genetic analysis of the T-H-2 region in non-t chromosomes. I. Two new congenic strains isolate Qglo-1 from H-2. Immunogenetics. 1983;17(5):445-55
(Latest) J:210602 Lewitus GM, et al., An adaptive role of TNFalpha in the regulation of striatal synapses. J Neurosci. 2014 Apr 30;34(18):6146-55
All references(1250)
Disease annotation references (1)
accession IDs
MGD-MRK-15151, MGD-MRK-28090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory