Msh2
Gene Detail

Symbol Name ID

Msh2 mutS homolog 2 (E. coli) MGI:101816

Feature Type

protein coding gene

Genetic Map

Chromosome 17

57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr17:87672330-87723713 bp, + strand From VEGA annotation of GRCm38   51384 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA mismatch repair protein, eukaryotic MSH2 type
Gene Tree: Msh2

Human homologs

Human Homolog		MSH2, mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
NCBI Gene ID		4436
neXtProt AC		NX_P43246
Human Synonyms		COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Human Chr (Location)		2p21; chr2:47630206-47710367 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MSH2

Alleles and phenotypes

All alleles(64) : Targeted(12) Gene trapped(52)
 

Mice homozygous for a number of different targeted mutations develop lymphomas. In addition, depending on the allele, mutants may show intestinal adenocarcinomas and reduced class switch recombination or adenocarcinomas and abnormal mismatch repair or squamous cell carcinomas and skin tumors.

 
Human Diseases Modeled Using Mouse Msh2 (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (102 annotations)

Process	ATP catabolic process, B cell differentiation, ...
Component	MutSalpha complex, MutSbeta complex, ...
Function	ADP binding, ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (6)    Images (5)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	5
Northern blot	5

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(140) Genomic(2) cDNA(138)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000038134 (Evidence)
Ensembl Gene Model	ENSMUSG00000024151 (Evidence)
Entrez Gene	17685 (Evidence)
UniGene	4619
DFCI	TC1575179
DoTS	DT.532582, DT.91445528
NIA Mouse Gene Index	U018325
Consensus CDS Project	CCDS29019.1
International Mouse Knockout Project Status	Msh2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038134	VEGA Gene Model | MGI Sequence Detail	51384	C57BL/6J
transcript	OTTMUST00000098216	VEGA | MGI Sequence Detail	3283	Not Applicable
polypeptide	OTTMUSP00000055147	VEGA | MGI Sequence Detail	935	Not Applicable

All sequences(44) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(215 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011184	DNA mismatch repair protein, MSH2
InterPro	IPR007861	DNA mismatch repair protein MutS, clamp
InterPro	IPR007860	DNA mismatch repair protein MutS, connector
InterPro	IPR007696	DNA mismatch repair protein MutS, core
InterPro	IPR000432	DNA mismatch repair protein MutS, C-terminal
InterPro	IPR007695	DNA mismatch repair protein MutS-like, N-terminal
Protein Ontology	PR:000010666	DNA mismatch repair protein Msh2

References

(Earliest) J:22127 Fishel R, et al., The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer [published erratum appears in Cell 1994 Apr 8;77(1):167]. Cell. 1993 Dec 3;75(5):1027-38
(Latest) J:192085 Bourn RL, et al., Pms2 suppresses large expansions of the (GAA.TTC)n sequence in neuronal tissues. PLoS One. 2012;7(10):e47085
All references(163)

Other accession IDs

MGD-MRK-18634, MGI:2146922