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Msh2
Gene Detail
Symbol

Name
ID
Msh2
mutS homolog 2 (E. coli)
MGI:101816
Feature Type
protein coding gene
Genetic Map
Chromosome 17
57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:87672330-87723713 bp, + strand
From VEGA annotation of GRCm38

  51384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA mismatch repair protein, eukaryotic MSH2 type
Gene Tree: Msh2

Human
homologs
Human Homolog MSH2, mutS homolog 2
NCBI Gene ID 4436
neXtProt AC  NX_P43246
Human Synonyms  COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Human Chr (Location)  2p21; chr2:47403067-47512577 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MSH2
Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(52) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a number of different targeted mutations develop lymphomas. In addition, depending on the allele, mutants may show intestinal adenocarcinomas and reduced class switch recombination or adenocarcinomas and abnormal mismatch repair or squamous cell carcinomas and skin tumors.
 
Human Diseases Modeled Using Mouse Msh2 (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Msh2 interacts with 78 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (101 annotations)
Process ATP catabolic process, B cell differentiation, ...
Component intracellular, membrane, ...
Function ADP binding, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (10)    Tissues (6)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
Northern blot 5
cDNA source data(136)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(141) Genomic(2) cDNA(139)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000038134 (Evidence)
Ensembl Gene ModelENSMUSG00000024151 (Evidence)
Entrez Gene17685 (Evidence)
UniGene4619
DFCITC1575179
DoTSDT.532582, DT.91445528
NIA Mouse Gene IndexU018325
Consensus CDS ProjectCCDS29019.1
International Mouse Knockout Project StatusMsh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038134 VEGA Gene Model | MGI Sequence Detail 51384 C57BL/6J ±  kb
transcript OTTMUST00000098216 VEGA | MGI Sequence Detail 3283 Not Applicable 
polypeptide OTTMUSP00000055147 VEGA | MGI Sequence Detail 935 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011184 DNA mismatch repair protein, MSH2
InterPro IPR007861 DNA mismatch repair protein MutS, clamp
InterPro IPR007860 DNA mismatch repair protein MutS, connector domain
InterPro IPR007696 DNA mismatch repair protein MutS, core
InterPro IPR000432 DNA mismatch repair protein MutS, C-terminal
InterPro IPR007695 DNA mismatch repair protein MutS-like, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010666 DNA mismatch repair protein Msh2
References
(Earliest) J:22127 Fishel R, et al., The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer [published erratum appears in Cell 1994 Apr 8;77(1):167]. Cell. 1993 Dec 3;75(5):1027-38
(Latest) J:213861 Peng M, et al., Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J. 2014 Aug 1;33(15):1698-712
All references(176)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-18634, MGI:2146922

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory