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Gene Detail
mutS homolog 2 (E. coli)
Feature Type protein coding gene
Genetic Map
Chromosome 17
57.87 cM
Detailed Genetic Map ± 1 cM

Mapping data(6)
Sequence Map
Chr17:87672330-87723713 bp, + strand
From VEGA annotation of GRCm38

  51384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA mismatch repair protein, eukaryotic MSH2 type
Gene Tree: Msh2

Human Homolog MSH2, mutS homolog 2
NCBI Gene ID 4436
neXtProt AC  NX_P43246
Human Synonyms  COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Human Chr (Location)  2p21; chr2:47403067-47512577 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MSH2
alleles, and
All mutations/alleles(64) : Gene trapped(52) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a number of different targeted mutations develop lymphomas. In addition, depending on the allele, mutants may show intestinal adenocarcinomas and reduced class switch recombination or adenocarcinomas and abnormal mismatch repair or squamous cell carcinomas and skin tumors.
Human Diseases Modeled Using Mouse Msh2 (1)    Alleles Annotated to Human Diseases(4)   
Msh2 interacts with 78 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (101 annotations)
Process ATP catabolic process, B cell differentiation, ...
Component intracellular, membrane, ...
Function ADP binding, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (6)    Images (5)
Theiler Stages: 23, 27
Assay TypeResults
RNA in situ 5
Northern blot 5
cDNA source data(136)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(141) Genomic(2) cDNA(139)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000038134 (Evidence)
Ensembl Gene ModelENSMUSG00000024151 (Evidence)
Entrez Gene17685 (Evidence)
DoTSDT.532582, DT.91445528
NIA Mouse Gene IndexU018325
Consensus CDS ProjectCCDS29019.1
International Mouse Knockout Project StatusMsh2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038134 VEGA Gene Model | MGI Sequence Detail 51384 C57BL/6J ±  kb
transcript OTTMUST00000098216 VEGA | MGI Sequence Detail 3283 Not Applicable 
polypeptide OTTMUSP00000055147 VEGA | MGI Sequence Detail 935 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(402 from dbSNP Build 137)
InterPro IPR011184 DNA mismatch repair protein, MSH2
InterPro IPR007861 DNA mismatch repair protein MutS, clamp
InterPro IPR007860 DNA mismatch repair protein MutS, connector domain
InterPro IPR007696 DNA mismatch repair protein MutS, core
InterPro IPR000432 DNA mismatch repair protein MutS, C-terminal
InterPro IPR007695 DNA mismatch repair protein MutS-like, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010666 DNA mismatch repair protein Msh2
References (Earliest) J:22127 Fishel R, et al., The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer [published erratum appears in Cell 1994 Apr 8;77(1):167]. Cell. 1993 Dec 3;75(5):1027-38
(Latest) J:209232 Grigera F, et al., Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination. PLoS One. 2013;8(10):e78370
All references(173)
Disease annotation references (2)
accession IDs
MGD-MRK-18634, MGI:2146922

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory