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Targeted Allele Detail
Symbol: Msh2tm2.1Rak
Name: mutS homolog 2; targeted mutation 2.1, Raju Kucherlapati
MGI ID: MGI:4460262
Synonyms: M2CKO, MSH2CKO, MSH2CKO pGKneo flipped ou, Msh2LoxP
Gene: Msh2  Location: Chr17:87979960-88031141 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance: Msh2tm2.1Rak page
Germline Transmission:  Earliest citation of germline transmission: J:161577
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 12, and an additional loxP site was inserted downstream of exon 12. Flp mediated recombination removed the neo cassette leaving exon 12 floxed. (J:161577)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Msh2tm2.1Rak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Msh2 Mutation:  95 strains or lines available
Original:  J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory