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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Msh2
mutS homolog 2
MGI:101816
32 phenotypes from 7 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Msh2tm1Htr/Msh2+
involves: 129P2/OlaHsd
increased hemangiosarcoma incidence J:45433
increased liver tumor incidence J:45433
increased lung tumor incidence J:45433
increased mammary gland tumor incidence J:45433
increased osteosarcoma incidence J:45433
increased skin tumor incidence J:45433
increased tumor incidence J:45433
increased uterus tumor incidence J:45433
premature death J:45433
Msh2tm1Htr/Msh2tm1Htr
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB)
increased T cell derived lymphoma incidence J:27469
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd
abnormal class switch recombination J:80893
abnormal inflammatory response J:80893
abnormal somatic hypermutation frequency J:155454
decreased IgG1 level J:80893
decreased IgG3 level J:80893
normal immune system phenotype J:47993
increased brain tumor incidence J:45433
increased gastrointestinal tumor incidence J:45433
increased lymphoma incidence J:45433
increased skin tumor incidence J:45433
increased T cell derived lymphoma incidence J:45433
increased tumor incidence J:45433
premature death J:45433
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd * FVB
increased gastrointestinal tumor incidence J:45433
increased incidence of tumors by chemical induction J:45433
increased lung tumor incidence J:45433
increased lymphoma incidence J:45433
increased mammary gland tumor incidence J:45433
increased skin tumor incidence J:45433
increased T cell derived lymphoma incidence J:45433
increased tumor incidence J:45433
increased uterus tumor incidence J:45433
premature death J:45433
Msh2tm1Mak/Msh2tm1Mak
C57BL/6NTac-Msh2tm1Mak
abnormal class switch recombination J:326431
abnormal somatic hypermutation frequency J:326431
Msh2tm1Mak/Msh2tm1Mak
involves: 129P2/OlaHsd * C57BL/6J
normal immune system phenotype J:28397
increased lymphoma incidence J:28397
premature death J:28397
Msh2tm1Rak/Msh2+
involves: 129P2/OlaHsd
colon polyps J:64667
increased liver adenoma incidence J:64667
increased lymphoma incidence J:64667
increased tumor incidence J:64667
Msh2tm1Rak/Msh2tm1Rak
involves: 129P2/OlaHsd
abnormal class switch recombination J:56764
decreased mature B cell number J:56764
increased gastrointestinal tumor incidence J:64667
increased lymphoma incidence J:64667
premature death J:64667
Msh2tm1Rak/Msh2tm1Rak
involves: 129P2/OlaHsd * C57BL/6
increased lymphoma incidence J:98929
premature death J:98929
Msh2tm1Rak/Msh2tm2.1Rak
Tg(Vil1-cre)20Syr/0
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
abnormal mismatch repair J:161577
abnormal physiological response to xenobiotic J:161577
abnormal tumor morphology J:161577
increased gastrointestinal tumor incidence J:161577
increased intestinal adenocarcinoma incidence J:161577
increased intestinal adenoma incidence J:161577
Msh2tm1Whl/Msh2tm1Whl
involves: 129P2/OlaHsd * C57BL/6J
abnormal tumor morphology J:79016
increased gastrointestinal tumor incidence J:79016
increased lymphoblastic lymphoma incidence J:79016
increased skin tumor incidence J:79016
increased squamous cell carcinoma incidence J:79016
premature death J:79016
Msh2tm2.1Rak/Msh2tm2.1Rak
involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
normal neoplasm J:161577
Msh2tm2.1Rak/Msh2tm2.1Rak
Tg(Vil1-cre)20Syr/0
involves: 129/Sv * C57BL/6 * FVB/N * SJL
abnormal mismatch repair J:161577
increased gastrointestinal tumor incidence J:161577
increased intestinal adenoma incidence J:161577
increased lymphoma incidence J:161577
increased small intestine adenocarcinoma incidence J:161577
premature death J:161577
Msh2tm2.1Rak/Msh2tm3.1Rak
Tg(Vil1-cre)20Syr/0
involves: 129/Sv * C57BL/6 * DBA/2 * SJL
abnormal mismatch repair J:161577
abnormal physiological response to xenobiotic J:161577
abnormal tumor morphology J:161577
increased gastrointestinal tumor incidence J:161577
increased intestinal adenocarcinoma incidence J:161577
increased intestinal adenoma incidence J:161577
Msh2tm2.2Rak/Msh2tm2.2Rak
involves: 129/Sv * C57BL/6 * FVB/N * SJL
abnormal mismatch repair J:161577
increased gastrointestinal tumor incidence J:161577
increased lymphoma incidence J:161577
premature death J:161577

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory