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Targeted Allele Detail
Symbol: Msh2tm3.1Rak
Name: mutS homolog 2; targeted mutation 3.1, Raju Kucherlapati
MGI ID: MGI:4460264
Synonyms: Msh2G674D
Gene: Msh2  Location: Chr17:87979960-88031141 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance: Msh2tm3.1Rak page
Germline Transmission:  Earliest citation of germline transmission: J:161577
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Hypomorph)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA floxed neo cassette was inserted upstream of modified exon 13 in which nucleotide substitutions (GGT to GAC) results in the amino acid substitution of aspartic acid for glycine at position 674 (G674D). Cre mediated recombination removed the neo cassette. (J:161577)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Msh2tm3.1Rak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh2 Mutation:  91 strains or lines available
Original:  J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory