About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4460268
Allelic
Composition
Msh2tm1Rak/Msh2tm2.1Rak
Tg(Vil1-cre)20Syr/0
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Rak mutation (1 available); any Msh2 mutation (95 available)
Msh2tm2.1Rak mutation (1 available); any Msh2 mutation (95 available)
Tg(Vil1-cre)20Syr mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• beginning at 6 months, mice develop intestinal tumors
• by 10 months, 50% of mice develop intestinal tumors
• mice develop fewer and larger tumors than in Msh2tm2.1Rak/Msh2tm3.1Wed Tg(Vil-cre)20Syr mice
• tumors do not respond to treatment with cisplatin or FOLFOX unlike tumors from Msh2tm2.1Rak/Msh2tm3.1Wed Tg(Vil-cre)20Syr mice

homeostasis/metabolism
• tumor cells exhibit increased microsatellite instability compared with wild-type cells
• tumors do not respond to treatment with cisplatin or FOLFOX unlike tumors from Msh2tm2.1Rak/Msh2tm3.1Wed Tg(Vil-cre)20Syr mice
• FOLFOX-treated intestinal mucosa exhibit decreased apoptosis compared with similarly treated cells from Msh2tm2.1Wed homozygotes and Msh2tm2.1Rak/Msh2tm3.1Wed Tg(Vil-cre)20Syr mice

cellular
• tumor cells exhibit increased microsatellite instability compared with wild-type cells

digestive/alimentary system
• beginning at 6 months, mice develop intestinal tumors
• by 10 months, 50% of mice develop intestinal tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Lynch syndrome DOID:3883 OMIM:PS120435
J:161577


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
09/24/2024
MGI 6.24
The Jackson Laboratory