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Targeted Allele Detail
Symbol: Tap1tm1Hpl
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); targeted mutation 1, Hidde Ploegh
MGI ID: MGI:1858161
Synonyms: TAP10
Gene: Tap1  Location: Chr17:34406530-34416199 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance: Tap1tm1Hpl page
Germline Transmission:  Earliest citation of germline transmission: J:60782
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequences encoding the second and part of the third transmembrane helices were replaced by a neomycin resistance gene. (J:60782)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Tap1tm1Hpl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tap1 Mutation:  30 strains or lines available
Original:  J:60782 Tourne S, et al., Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1464-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory