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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(IghMyc)22Bri
transgene insertion 22, Ralph L Brinster
MGI:2447604
Summary 58 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Atmintm1.1Jhh/Atmintm1.1Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
B6.Cg-Bcl2l11tm1.1Ast Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri MGI:5755464
cn2
Atmintm1.1Jhh/Atmintm1.1Jhh
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri MGI:5755462
cn3
Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Tg(IghMyc)22Bri/0
B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth Tg(IghMyc)22Bri MGI:5755458
cn4
Tg(IghMyc)22Bri/0
Xiaptm1Hs/Xiaptm1Hs
B6.Cg-Xiaptm1Hs Tg(IghMyc)22Bri MGI:3809794
cx5
Mdm2tm1.1Ypz/Mdm2+
Tg(IghMyc)22Bri/0
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri MGI:4836994
cx6
Mdm2tm1.1Ypz/Mdm2tm1.1Ypz
Tg(IghMyc)22Bri/0
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri MGI:4836993
cx7
Prdm11tm1.1Ahl/Prdm11tm1.1Ahl
Tg(IghMyc)22Bri/0
B6.Cg-Prdm11tm1.1Ahl Tg(IghMyc)22Bri MGI:6381653
cx8
Kat5tm1Jwl/Kat5+
Tg(IghMyc)22Bri/0
Trp53tm1Tyj/Trp53+
involves: 129 * C57BL * C57BL/6 * SJL MGI:3814381
cx9
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Trp53tm1Brd/Trp53+
involves: 129 * C57BL * FVB/N * SJL MGI:3710184
cx10
Cdkn2atm1Cjs/Cdkn2a+
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
involves: 129 * C57BL * FVB/N * SJL MGI:3710182
cx11
Atmtm1Awb/Atmtm1Awb
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
involves: 129 * C57BL * FVB/N * SJL MGI:3710183
cx12
Trp53tm2.1Thst/Trp53+
Tg(IghMyc)22Bri/0
involves: 129 * C57BL * SJL MGI:6479118
cx13
Crebbptm2Pkb/Crebbp+
Tg(IghMyc)22Bri/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3626200
cx14
Cul9tm1.2Yxi/Cul9tm1.2Yxi
Tg(IghMyc)22Bri/0
involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL MGI:5007745
cx15
Cul9tm1.2Yxi/Cul9+
Tg(IghMyc)22Bri/0
involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL MGI:5007744
cx16
Plcg2tm1Jni/Plcg2tm1Jni
Tg(IghMyc)22Bri/0
involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL MGI:4940206
cx17
Trp53tm1.1Thst/Trp53+
Tg(IghMyc)22Bri/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL * SJL MGI:5518944
cx18
Kat5tm1Jwl/Kat5+
Tg(IghMyc)22Bri/0
involves: 129S1/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL MGI:3814376
cx19
Trp53tm1Thst/Trp53+
Tg(IghMyc)22Bri/0
involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL MGI:5518945
cx20
Npm1tm1Ppp/Npm1+
Tg(IghMyc)22Bri/0
involves: 129S1/Sv * C57BL/6 * SJL MGI:3606872
cx21
Ighmtm1Cgn/Ighmtm1Cgn
Tg(IghMyc)22Bri/0
involves: 129S2/SvPas * C57BL * SJL MGI:5437736
cx22
Dnmt1tm1(tetO-BCL2)Sjk/Dnmt1+
Tg(IghMyc)22Bri/0
Tg(MMTVtTA)1Mam/0
involves: 129S4/SvJae * C57BL/6 MGI:3511863
cx23
Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(IghMyc)22Bri/?
involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662410
cx24
Mirc1tm2.1Aven/Mirc1+
Tg(IghMyc)22Bri/?
involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662414
cx25
Ep300tm3Pkb/Ep300+
Tg(IghMyc)22Bri/0
involves: 129S6/SvEvTac * C57BL/6 MGI:3626202
cx26
Mdm4tm1Glo/Mdm4+
Tg(IghMyc)22Bri/0
involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL MGI:3850699
cx27
Ep300tm3Pkb/Ep300+
Tg(IghMyc)22Bri/0
involves: 129S6/SvEvTac * C57BL * SJL MGI:3626201
cx28
Mapk14tm1.1Dvb/Mapk14+
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL MGI:3710181
cx29
Ppm1dtm1Lad/Ppm1d+
Tg(IghMyc)22Bri/0
involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL MGI:3710179
cx30
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL MGI:3710180
cx31
Tg(IghMyc)22Bri/0
Trp53tm1Tyj/Trp53+
involves: 129/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL MGI:3814379
cx32
Dmtf1tm1Cjs/Dmtf1+
Tg(IghMyc)22Bri/0
involves: 129/Sv * C57BL * C57BL/6 * SJL MGI:3692583
cx33
Klrb1btm1.1Apma/Klrb1btm1.1Apma
Tg(IghMyc)22Bri/0
involves: BALB/c * C57BL * C57BL/6 * SJL MGI:5896645
cx34
Boktm1.1Ast/Boktm1.1Ast
Tg(IghMyc)22Bri/0
involves: BALB/cJ * C57BL * C57BL/6 * SJL MGI:5527392
cx35
Tg(Igh-Abl1)40Sco/0
Tg(IghMyc)22Bri/0
involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi MGI:2665034
cx36
Tg(BCL2)22Wehi/0
Tg(IghMyc)22Bri/0
involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi MGI:2662422
cx37
Klrk1tm1Dhr/Klrk1tm1Dhr
Tg(IghMyc)22Bri/?
involves: C57BL/6 * CD-1 MGI:3790962
cx38
Tg(IghMyc)22Bri/0
Tg(Igk-V21-Bax)1967Bvn/0
involves: C57BL/6 * FVB/N MGI:3046406
cx39
Prps2tm1a(KOMP)Wtsi/Y
Tg(IghMyc)22Bri/0
involves: C57BL/6N * SJL MGI:5648425
cx40
Bcl2l11tm3.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
involves: C57BL/6 * SJL MGI:5433595
cx41
Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Tg(IghMyc)22Bri/0
involves: C57BL/6 * SJL MGI:5433582
cx42
Bcl2l11tm2.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
involves: C57BL/6 * SJL MGI:5433585
cx43
Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Tg(IghMyc)22Bri/0
involves: C57BL/6 * SJL MGI:5433594
cx44
Bcl2l11tm1.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
involves: C57BL/6 * SJL MGI:5433579
cx45
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Tg(IghMyc)22Bri/0
involves: C57BL/6 * SJL MGI:5433596
cx46
Tg(EmuSR-tTa)83Bop/0
Tg(IghMyc)22Bri/0
Tg(tetO-RNAi:Trp53)ASlowe/0
involves: C57BL * C57BL/6 * FVB/N * SJL MGI:5521543
cx47
Fnip1LPAB.1/Fnip1LPAB.1
Tg(IghMyc)22Bri/0
involves: C57BL * C57BL/6J * SJL MGI:5437735
cx48
Ube2otm1.1(KOMP)Mbp/Ube2otm1.1(KOMP)Mbp
Tg(IghMyc)22Bri/0
involves: C57BL * C57BL/6N * FVB/N * SJL MGI:5902968
cx49
Cks1btm1Sir/Cks1btm1Sir
Tg(IghMyc)22Bri/?
involves: C57BL * C57BL/6 * SJL MGI:3711763
cx50
Cks1btm1Sir/Cks1b+
Tg(IghMyc)22Bri/?
involves: C57BL * C57BL/6 * SJL MGI:3711765
cx51
Pknox1tm1Ngc/Pknox1+
Tg(IghMyc)22Bri/0
involves: C57BL * SJL MGI:5469883
cx52
Tg(IghMyc)22Bri/0
Tg(Lck/Emu-Eif4e)#Ppp/0
involves: C57BL * SJL MGI:5510991
cx53
Tg(ACTB-Eif4e)#Ppp/0
Tg(IghMyc)22Bri/0
involves: C57BL * SJL MGI:5510989
tg54
Tg(IghMyc)22Bri/0 B6.Cg-Tg(IghMyc)22Bri/J MGI:4836997
tg55
Tg(IghMyc)22Bri/0 involves: C57BL/6N * SJL MGI:5648426
tg56
Tg(IghMyc)22Bri/0 involves: C57BL/6 * SJL MGI:3811798
tg57
Tg(IghMyc)22Bri/0 involves: C57BL * C57BL/6 * SJL MGI:4940207
tg58
Tg(IghMyc)22Bri/? involves: C57BL * C57BL/6 * SJL MGI:3711764


Genotype
MGI:5755464
cn1
Allelic
Composition
Atmintm1.1Jhh/Atmintm1.1Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Bcl2l11tm1.1Ast Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.1Jhh mutation (1 available); any Atmin mutation (19 available)
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (16 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• compared with Tg(IghMyc)22Bri mice




Genotype
MGI:5755462
cn2
Allelic
Composition
Atmintm1.1Jhh/Atmintm1.1Jhh
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.1Jhh mutation (1 available); any Atmin mutation (19 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 7.5-fold compared with Tg(IghMyc)22Bri mice
• 60-fold compared with Cd79atm1(Cre)Reth/Cd79a+ or Tg(IghMyc)22Bri mice

neoplasm
• compared with Tg(IghMyc)22Bri mice
• compared with Tg(IghMyc)22Bri mice
• however, the range to tumor types is the same

cellular

hematopoietic system
• 7.5-fold compared with Tg(IghMyc)22Bri mice
• 60-fold compared with Cd79atm1(Cre)Reth/Cd79a+ or Tg(IghMyc)22Bri mice




Genotype
MGI:5755458
cn3
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (16 available)
Dynll1tm1.1Jhh mutation (1 available); any Dynll1 mutation (15 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• greater than 50-fold

neoplasm
• compared with Tg(IghMyc)22Bri mice

hematopoietic system
• greater than 50-fold




Genotype
MGI:3809794
cn4
Allelic
Composition
Tg(IghMyc)22Bri/0
Xiaptm1Hs/Xiaptm1Hs
Genetic
Background
B6.Cg-Xiaptm1Hs Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Xiaptm1Hs mutation (1 available); any Xiap mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit increased survival compared to Tg(IghMyc)22Bri mice

immune system
• compared to in Tg(IghMyc)22Bri mice
• compared to in Tg(IghMyc)22Bri mice
• peripheral white blood counts are lower than in Tg(IghMyc)22Bri mice that develop leukemia

hematopoietic system
• compared to in Tg(IghMyc)22Bri mice
• compared to in Tg(IghMyc)22Bri mice
• peripheral white blood counts are lower than in Tg(IghMyc)22Bri mice that develop leukemia

cellular
• compared to in Tg(IghMyc)22Bri mice
• compared to in Tg(IghMyc)22Bri mice




Genotype
MGI:4836994
cx5
Allelic
Composition
Mdm2tm1.1Ypz/Mdm2+
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1.1Ypz mutation (2 available); any Mdm2 mutation (45 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 15 weeks




Genotype
MGI:4836993
cx6
Allelic
Composition
Mdm2tm1.1Ypz/Mdm2tm1.1Ypz
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1.1Ypz mutation (2 available); any Mdm2 mutation (45 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

mortality/aging
• median survival is 9 weeks

immune system

neoplasm
• lymphomagenesis is accelerated compared to in Tg(IghMyc)22Bri mice

liver/biliary system

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:6381653
cx7
Allelic
Composition
Prdm11tm1.1Ahl/Prdm11tm1.1Ahl
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Prdm11tm1.1Ahl Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm11tm1.1Ahl mutation (0 available); any Prdm11 mutation (3 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice show accelerated development of B-cell lymphomas, with a median survival of 94 days versus 113 days in single Tg(IghMyc)22Bri mice
• however, no difference in tumor load or in proliferation are seen and no differences in cell cycle profiles or apoptotic index are seen




Genotype
MGI:3814381
cx8
Allelic
Composition
Kat5tm1Jwl/Kat5+
Tg(IghMyc)22Bri/0
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129 * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5tm1Jwl mutation (0 available); any Kat5 mutation (19 available)
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die prior to 20 weeks of age

neoplasm
• mice exhibit an earlier age of onset and enhanced penetrance of B cell lymphomas compared to in Tg(IghMyc)22Bri mice




Genotype
MGI:3710184
cx9
Allelic
Composition
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129 * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (2 available)
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of 31 days

neoplasm
• based on median survival time, mice carrying single Trp53tm1Brd allele were no more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele




Genotype
MGI:3710182
cx10
Allelic
Composition
Cdkn2atm1Cjs/Cdkn2a+
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129 * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (6 available); any Cdkn2a mutation (36 available)
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (2 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of >130 days

neoplasm
• similar to mice carrying double Ppm1dtm1Lad allele without Cdkn2atm1Cjs allele, based on increased median survival time, mice carrying single Cdkn2atm1Cjs allele were considerably more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele




Genotype
MGI:3710183
cx11
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129 * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (34 available)
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (2 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of 69 days

neoplasm
• based on median survival time, mice carrying double Atmtm1Awb allele were no more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele




Genotype
MGI:6479118
cx12
Allelic
Composition
Trp53tm2.1Thst/Trp53+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129 * C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm2.1Thst mutation (0 available); any Trp53 mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• similar to mice with a null Trp53 allele, mice exhibit shorter survival than those with wild-type Trp53




Genotype
MGI:3626200
cx13
Allelic
Composition
Crebbptm2Pkb/Crebbp+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (18 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• on a hybrid background presence of a single Crebbtm2Pkb allele decreased the median survival time by about 8-10 weeks compared to wild-type transgenic littermates




Genotype
MGI:5007745
cx14
Allelic
Composition
Cul9tm1.2Yxi/Cul9tm1.2Yxi
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul9tm1.2Yxi mutation (0 available); any Cul9 mutation (63 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lymphoma-free survival is 85.1 months compared with 126.4 months for Tg(IghMyc)22Bri mice

neoplasm
• lymphoma cell clusters spread throughout the liver parenchyma and exhibit various degrees of lung and pancreas infiltration unlike in Tg(IghMyc)22Bri mice
• mice develop lymphomas by 25 days of age
• 3 of 5 mice younger than 2 months of age develop lymphomas unlike Tg(IghMyc)22Bri mice
• by 5 months, 10 of 10 of mice develop lymphomas compared with 6 of 9 Tg(IghMyc)22Bri mice
• all lymphomas are B cell or pre-B cell lymphomas




Genotype
MGI:5007744
cx15
Allelic
Composition
Cul9tm1.2Yxi/Cul9+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul9tm1.2Yxi mutation (0 available); any Cul9 mutation (63 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lymphoma-free survival is 108.9 months compared with 126.4 months for Tg(IghMyc)22Bri mice

neoplasm
• lymphoma cell clusters spread throughout the liver parenchyma and exhibit various degrees of lung and pancreas infiltration unlike in Tg(IghMyc)22Bri mice
• 3 of 5 mice younger than 2 months of age develop lymphomas unlike Tg(IghMyc)22Bri mice
• by 5 months, 16 of 20 of mice develop lymphomas compared with 6 of 9 Tg(IghMyc)22Bri mice
• all lymphomas are B cell or pre-B cell lymphomas




Genotype
MGI:4940206
cx16
Allelic
Composition
Plcg2tm1Jni/Plcg2tm1Jni
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2tm1Jni mutation (2 available); any Plcg2 mutation (47 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean mortality is 10 weeks

immune system
• by 8 weeks

neoplasm
• development of lymphoma is accelerated compared to in Tg(IghMyc)22Bri mice
• lymphomas are composed of large pre-B cells unlike in Tg(IghMyc)22Bri mice




Genotype
MGI:5518944
cx17
Allelic
Composition
Trp53tm1.1Thst/Trp53+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm1.1Thst mutation (0 available); any Trp53 mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compared with Tg(IghMyc)22Bri mice
• median survival is 10 days longer than in Trp53tm1Thst/Trp53+ Tg(IghMyc)22Bri mice

neoplasm
• with increased apoptosis and senescence staining in tumors from Tg(IghMyc)22Bri mice




Genotype
MGI:3814376
cx18
Allelic
Composition
Kat5tm1Jwl/Kat5+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5tm1Jwl mutation (0 available); any Kat5 mutation (19 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die prior to 30 weeks of age

neoplasm
• mice exhibit an earlier age of onset and enhanced penetrance of B cell lymphomas compared to in Tg(IghMyc)22Bri mice
• tumor cells exhibit replacement of the knock-out allele with a wild-type allele

immune system
• B cells exhibit severely impaired Myc-induced DNA damage repair

homeostasis/metabolism
• B cells exhibit severely impaired Myc-induced DNA damage repair
• however, DNA damage repair following ionizing radiation exposure is normal

cellular
• B cells exhibit severely impaired Myc-induced DNA damage repair
• however, DNA damage repair following ionizing radiation exposure is normal

hematopoietic system
• B cells exhibit severely impaired Myc-induced DNA damage repair




Genotype
MGI:5518945
cx19
Allelic
Composition
Trp53tm1Thst/Trp53+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm1Thst mutation (0 available); any Trp53 mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compared with Tg(IghMyc)22Bri mice

neoplasm




Genotype
MGI:3606872
cx20
Allelic
Composition
Npm1tm1Ppp/Npm1+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npm1tm1Ppp mutation (0 available); any Npm1 mutation (23 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• all lymphomas have numerical chromosomal abnormalities unlike in Tg(IghMyc)22Bri animals, however only 1 of 4 tumors show structural abnormalities that are seen in the transgenic mice alone
• B cell lymphoma onset is significantly accelerated compared to Tg(IghMyc)22Bri mice
• all lymphomas have numerical chromosomal abnormalities unlike Tg(IghMyc)22Bri animals, however only 1 of 4 tumors show structural abnormalities that are seen in the transgenic mice alone




Genotype
MGI:5437736
cx21
Allelic
Composition
Ighmtm1Cgn/Ighmtm1Cgn
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S2/SvPas * C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (23 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm




Genotype
MGI:3511863
cx22
Allelic
Composition
Dnmt1tm1(tetO-BCL2)Sjk/Dnmt1+
Tg(IghMyc)22Bri/0
Tg(MMTVtTA)1Mam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1(tetO-BCL2)Sjk mutation (0 available); any Dnmt1 mutation (40 available)
Tg(IghMyc)22Bri mutation (1 available)
Tg(MMTVtTA)1Mam mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in the absence of doxycycline, mutants develop an enlarged spleen with doxycycline treatment the spleen returns to its normal size

mortality/aging
• without doxycycline treatment median survival is 82 days, with doxycycline treatment the improves to 145 days

neoplasm
• in the absence of doxycycline, lymphoblastic leukemia is seen by 2 weeks of age
• in 5 - 7 week old triple transgenics with lymphoblastic leukemia doxycycline treatment resulted in normalization of the WBC count and restoration of normal hematopoiesis
• bulky B cell derived lymphomas, similar to those in Tg(IghMyc)22Bri single transgenics, are seen in older triple transgenics after treatment with doxycycline

behavior/neurological
• transgenics with leukemia are lethargic, doxycycline treatment returns activity levels to normal

hematopoietic system
• in the absence of doxycycline, mutants develop an enlarged spleen with doxycycline treatment the spleen returns to its normal size

immune system
• in the absence of doxycycline, mutants develop an enlarged spleen with doxycycline treatment the spleen returns to its normal size




Genotype
MGI:5662410
cx23
Allelic
Composition
Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(IghMyc)22Bri/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

mortality/aging
• increase in survival as compared to mice carrying Tg(IghMyc)22Bri alone and mice carrying Tg(IghMyc)22Bri and heterozygous for Mirc1tm2.1Aven

hematopoietic system
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone
• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

immune system
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone
• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

neoplasm
• immunophenotype of B cell lymphomas is altered (increase in in IgM+ tumors) as compared to Tg(IghMyc)22Bri alone
• as compared to mice carrying only Tg(IghMyc)22Bri




Genotype
MGI:5662414
cx24
Allelic
Composition
Mirc1tm2.1Aven/Mirc1+
Tg(IghMyc)22Bri/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increase in survival as compared to mice carrying Tg(IghMyc)22Br




Genotype
MGI:3626202
cx25
Allelic
Composition
Ep300tm3Pkb/Ep300+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300tm3Pkb mutation (2 available); any Ep300 mutation (62 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• on a C57BL/6 background, surivival of transgenic mutants carrying the mutant Ep300 allele were identical to that of Ep300-sufficient transgenic mice




Genotype
MGI:3850699
cx26
Allelic
Composition
Mdm4tm1Glo/Mdm4+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm1Glo mutation (0 available); any Mdm4 mutation (155 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop B cell lymphomas
• however, lymphomagenesis is delayed compared to in Tg(IghMyc)22Bri mice




Genotype
MGI:3626201
cx27
Allelic
Composition
Ep300tm3Pkb/Ep300+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300tm3Pkb mutation (2 available); any Ep300 mutation (62 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• on a hybrid background presence of a single Ep300tm3Pkb allele decreased the median survival time by about 8-10 weeks compared to wild-type transgenic littermates




Genotype
MGI:3710181
cx28
Allelic
Composition
Mapk14tm1.1Dvb/Mapk14+
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1.1Dvb mutation (1 available); any Mapk14 mutation (19 available)
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (2 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of 130 days

neoplasm
• similar to mice carrying double Ppm1dtm1Lad allele without Mapk14tm1Dvb allele, based on increased median survival time, mice carrying single Mapk14tm1Dvb allele were considerably more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele




Genotype
MGI:3710179
cx29
Allelic
Composition
Ppm1dtm1Lad/Ppm1d+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (2 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of 107 days

neoplasm
• mice carrying a single Ppm1dtm1Lad allele were considerably more resistant to tumor formation induced by myc than wild-type transgenic litter mates based on increased median survival time by about 30 days




Genotype
MGI:3710180
cx30
Allelic
Composition
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (2 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of 138 days

neoplasm
• mice carrying double Ppm1dtm1Lad allele were considerably more resistant to tumor formation induced by myc than wild-type transgenic litter mates based on increased median survival time by about 60 days




Genotype
MGI:3814379
cx31
Allelic
Composition
Tg(IghMyc)22Bri/0
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die prior to 20 weeks of age

neoplasm
• mice exhibit an earlier age of onset and enhanced penetrance of B cell lymphomas compared to in Tg(IghMyc)22Bri mice




Genotype
MGI:3692583
cx32
Allelic
Composition
Dmtf1tm1Cjs/Dmtf1+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129/Sv * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1tm1Cjs mutation (3 available); any Dmtf1 mutation (66 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• accelerated tumor formation as compared to mice carrying only Tg(IghMyc)22Bri




Genotype
MGI:5896645
cx33
Allelic
Composition
Klrb1btm1.1Apma/Klrb1btm1.1Apma
Tg(IghMyc)22Bri/0
Genetic
Background
involves: BALB/c * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klrb1btm1.1Apma mutation (0 available); any Klrb1b mutation (1 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• delayed onset of B cell lymphoma compared with Tg(IghMyc)22Bri mice




Genotype
MGI:5527392
cx34
Allelic
Composition
Boktm1.1Ast/Boktm1.1Ast
Tg(IghMyc)22Bri/0
Genetic
Background
involves: BALB/cJ * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Boktm1.1Ast mutation (0 available); any Bok mutation (12 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• as in Tg(IghMyc)22Bri mice




Genotype
MGI:2665034
cx35
Allelic
Composition
Tg(Igh-Abl1)40Sco/0
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Igh-Abl1)40Sco mutation (0 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• accelerated development of plasmacytomas compared to single Tg(Igh-Abl1)40Sco transgenic mice, with mice becoming ill between 5 and 8 weeks of age; especially prominent in the intestine
• tumors are oligoclonal and often secrete IgM
• however, double transgenics do not develop pre-B or B lymphomas, as observed in single Tg(IghMyc)22Bri mice

immune system
• 64% of transgenics exhibit enlarged mesenteric lymph nodes due to engorgement with plasmacytoma cells




Genotype
MGI:2662422
cx36
Allelic
Composition
Tg(BCL2)22Wehi/0
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation (2 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

mortality/aging
• animals become terminally ill at 5-6 weeks of age

neoplasm
• masses of lymphoblasts occupy the spleen, lymph nodes and thymus and extensively invade the bone marrow, liver, lungs, and kidneys, an indication of malignant lymphoma
• tumors derive from a cell with the hallmarks of a primitive hematopoietic cell

hematopoietic system
• 50- to 100-fold higher levels of white blood cells compared to controls
• enlarged B cells
• 70% increase in numbers of B cells in bone marrow and spleen
• enlarged pre-B cells
• 30% increase in numbers of pre-B cells in bone marrow and spleen

immune system
• 50- to 100-fold higher levels of white blood cells compared to controls
• enlarged B cells
• 70% increase in numbers of B cells in bone marrow and spleen
• enlarged pre-B cells
• 30% increase in numbers of pre-B cells in bone marrow and spleen

endocrine/exocrine glands




Genotype
MGI:3790962
cx37
Allelic
Composition
Klrk1tm1Dhr/Klrk1tm1Dhr
Tg(IghMyc)22Bri/?
Genetic
Background
involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klrk1tm1Dhr mutation (3 available); any Klrk1 mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• lymphomas develop significantly earlier in these mice than in mice carrying the transgene on a wild-type background
• the mean time of onset is 7 weeks earlier than in the control group with all mice have detectable tumors by 30 weeks of age
• the tumors consist of a mix pre-B and B cells lymphomas




Genotype
MGI:3046406
cx38
Allelic
Composition
Tg(IghMyc)22Bri/0
Tg(Igk-V21-Bax)1967Bvn/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Tg(Igk-V21-Bax)1967Bvn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 4 - 6 week old double transgenic exhibit severe splenomegaly

mortality/aging
• 50% of double transgenics die of a lymphoproliferative disorder by 5.5 weeks

neoplasm
• multifocal to coalescent infiltrations of mononuclear cells with large round to polygonal hypochromatic nuclei are seen in the kidneys, spleen, lymph node, liver, ung, heart, thymus, pancreas, and sternal bone marrow
• osteolytic lesions with cheets of pleomorphic plasmacytic cells adjacent to lysed osseous trabeculae are seen

hematopoietic system
• 4 - 6 week old double transgenic exhibit severe splenomegaly
• the number of immature/transitional B cells is increased

immune system
• 4 - 6 week old double transgenic exhibit severe splenomegaly
• the number of immature/transitional B cells is increased

liver/biliary system
• multiple beige nodules up to 2 mm in diameter are seen




Genotype
MGI:5648425
cx39
Allelic
Composition
Prps2tm1a(KOMP)Wtsi/Y
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prps2tm1a(KOMP)Wtsi mutation (0 available); any Prps2 mutation (0 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 60% of mice live beyond 200 days at which point most mice carrying the transgene alone have died

neoplasm
• dramatic delay in tumor initiation compared to mice carrying the transgene alone

hematopoietic system
N
• overall rate of protein synthesis in B lymphocytes is reduced towards normal levels unlik in mice carrying Tg(IghMyc)22Bri alone
• B lymphocytes show increased glucose uptake and increased rate of glucose oxidation compared to mice carrying the transgene alone
• no alterations in mitochondrial mass or mitochondrial membrane potential are detected
• dramatic increase in B lymphocytes compared to mice carrying the transgene alone

immune system
• B lymphocytes show increased glucose uptake and increased rate of glucose oxidation compared to mice carrying the transgene alone
• no alterations in mitochondrial mass or mitochondrial membrane potential are detected
• dramatic increase in B lymphocytes compared to mice carrying the transgene alone

cellular
• dramatic increase in B lymphocytes compared to mice carrying the transgene alone




Genotype
MGI:5433595
cx40
Allelic
Composition
Bcl2l11tm3.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median lifespan is 110 days, which is similar to single Tg(IghMyc)22Bri hemizygotes

neoplasm
• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)




Genotype
MGI:5433582
cx41
Allelic
Composition
Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of 50 days

neoplasm
• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)

hematopoietic system
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes

immune system
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes




Genotype
MGI:5433585
cx42
Allelic
Composition
Bcl2l11tm2.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average survival is 70 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days

neoplasm
• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)

hematopoietic system
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

immune system
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes




Genotype
MGI:5433594
cx43
Allelic
Composition
Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of 58 days

neoplasm
• mutants exhibit a mixture of sIg- pre-B lymphoma (~60%) and sIg+ B lymphoma (~40%)

hematopoietic system
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes

immune system
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes




Genotype
MGI:5433579
cx44
Allelic
Composition
Bcl2l11tm1.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mutants exhibit a rare incidence of Thy1+ T lymphoma

mortality/aging
• median survival is 64 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days

neoplasm
• mutants exhibit a rare incidence of Thy1+ T lymphoma
• mutants exhibit a mixture of sIg- pre-B lymphoma (~65%) and sIg+ B lymphoma (~35%)

hematopoietic system
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

immune system
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes




Genotype
MGI:5433596
cx45
Allelic
Composition
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (16 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median lifespan is 84 days, which is not statistically different from single Tg(IghMyc)22Bri hemizygotes

neoplasm
• mutants exhibit a mix of sIg- pre-B lymphoma (~50%) and sIg+ B lymphoma (~50%)




Genotype
MGI:5521543
cx46
Allelic
Composition
Tg(EmuSR-tTa)83Bop/0
Tg(IghMyc)22Bri/0
Tg(tetO-RNAi:Trp53)ASlowe/0
Genetic
Background
involves: C57BL * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EmuSR-tTa)83Bop mutation (0 available)
Tg(IghMyc)22Bri mutation (1 available)
Tg(tetO-RNAi:Trp53)ASlowe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• spleen is enlarged and taken over by B220+ IgM- (pre-B) tumor cells, with lymphoma dissemination into the lymph nodes and liver

mortality/aging
• mutants become moribund without a large peripheral tumor burden, with a median survival of 82 days

neoplasm
• mutants develop lymphoma, with latency of tumorigenesis reduced compared to single Tg(IghMyc)22Bri/0 mice
• lymphoma-bearing mice treated with doxycycline at the onset of paralysis regain full movement within 2 days of doxycycline treatment, show tumor involution, and live for a further 24-64 days before tumors relapse

hematopoietic system
• spleen is enlarged and taken over by B220+ IgM- (pre-B) tumor cells, with lymphoma dissemination into the lymph nodes and liver

immune system
• spleen is enlarged and taken over by B220+ IgM- (pre-B) tumor cells, with lymphoma dissemination into the lymph nodes and liver

behavior/neurological
• partial hind leg paralysis is seen in some mutants, most likely attributed to lymphoma




Genotype
MGI:5437735
cx47
Allelic
Composition
Fnip1LPAB.1/Fnip1LPAB.1
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1LPAB.1 mutation (0 available); any Fnip1 mutation (1 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• pre-B cell lymphomagenesis induced by c-Myc expression is inhibited

immune system
• of B220+CD43+ Emu-Myc pre-B cells

cellular
• of B220+CD43+ Emu-Myc pre-B cells

hematopoietic system
• of B220+CD43+ Emu-Myc pre-B cells




Genotype
MGI:5902968
cx48
Allelic
Composition
Ube2otm1.1(KOMP)Mbp/Ube2otm1.1(KOMP)Mbp
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Ube2otm1.1(KOMP)Mbp mutation (1 available); any Ube2o mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• as in Tg(IghMyc)22Bri mice

neoplasm
• as in Tg(IghMyc)22Bri mice




Genotype
MGI:3711763
cx49
Allelic
Composition
Cks1btm1Sir/Cks1btm1Sir
Tg(IghMyc)22Bri/?
Genetic
Background
involves: C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation (0 available); any Cks1b mutation (5 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice

mortality/aging
• mean survival after lymphomas develop is 268 days compared to 91 days in Tg(IghMyc)22Bri mice and 101 days in Tg(IghMyc)22Bri Cks1btm1Sir heterozygotes

neoplasm
• only 1 of 9 diseased mice show moderate bone marrow infiltration and none presented with liver or meningeal infiltrates present in Tg(IghMyc)22Bri mice
• delayed development of lymphomas compared to Tg(IghMyc)22Bri mice

immune system
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice
• 5.4+/-0.4x106ul compared to 6.9+/-0.4x106ul in Tg(IghMyc)22Bri mice
• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)

hematopoietic system
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice
• 5.4+/-0.4x106ul compared to 6.9+/-0.4x106ul in Tg(IghMyc)22Bri mice
• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)




Genotype
MGI:3711765
cx50
Allelic
Composition
Cks1btm1Sir/Cks1b+
Tg(IghMyc)22Bri/?
Genetic
Background
involves: C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation (0 available); any Cks1b mutation (5 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival after lymphomas development is 101 days

neoplasm




Genotype
MGI:5469883
cx51
Allelic
Composition
Pknox1tm1Ngc/Pknox1+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1tm1Ngc mutation (0 available); any Pknox1 mutation (77 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pro-B tumor in Pknox1tm1Ngc/Pknox1+ Tg(IghMyc)22Bri/0 mice

mortality/aging
• median survival time is 23 weeks compared with 58 weeks for Tg(IghMyc)22Bri mice

immune system
• in the spleen

neoplasm
• accelerated and enhanced immature B cell lymphomas compared with Tg(IghMyc)22Bri mice

cellular
• in the spleen

hematopoietic system
• in the spleen




Genotype
MGI:5510991
cx52
Allelic
Composition
Tg(IghMyc)22Bri/0
Tg(Lck/Emu-Eif4e)#Ppp/0
Genetic
Background
involves: C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Tg(Lck/Emu-Eif4e)#Ppp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• onset of lymphoma is accelerated compared to single Tg(IghMyc)22Bri transgenic mice




Genotype
MGI:5510989
cx53
Allelic
Composition
Tg(ACTB-Eif4e)#Ppp/0
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-Eif4e)#Ppp mutation (0 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• onset of lymphoma is accelerated compared to single Tg(IghMyc)22Bri transgenic mice and is evident at less than 1 month of age

cellular
• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice

immune system
• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice

hematopoietic system
• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice




Genotype
MGI:4836997
tg54
Allelic
Composition
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Tg(IghMyc)22Bri/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• moderately at 4 weeks of age

mortality/aging
• median survival is 20 weeks

immune system
• moderately at 4 weeks of age

neoplasm

hematopoietic system
• moderately at 4 weeks of age




Genotype
MGI:5648426
tg55
Allelic
Composition
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• almost all mice die by 200 days of age

neoplasm

hematopoietic system
• in B lymphocytes compared to wild-type controls but reduced compared to mice carrying the transgene and homozygous for Prps2tm1a(KOMP)Wtsi

immune system
• in B lymphocytes compared to wild-type controls but reduced compared to mice carrying the transgene and homozygous for Prps2tm1a(KOMP)Wtsi

cellular
• in B lymphocytes compared to wild-type controls but reduced compared to mice carrying the transgene and homozygous for Prps2tm1a(KOMP)Wtsi




Genotype
MGI:3811798
tg56
Allelic
Composition
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• two-fold

mortality/aging
• mice die at 6 to 15 weeks of age with 94% of mice dying by 4 months of age (J:78177)
• median survival is 100 days (J:186117)

neoplasm
• mice occasionally develop thyoma without involvement of peripheral lymphoid organs
• mice develop multicentric lymphosarcoma associated with leukemia
• 13 of 15 mice develop lymphomas (J:78177)
• mice develop multicentric lymphosarcoma associated with leukemia (J:78177)
• lymphomas develop from single B-lymphoid clones at different stages of differentiation (J:78177)
• mutants exhibit a mixture of sIg- pre-B lymphoma (~40%) and sIg+ B lymphoma (~60%) (J:186117)
• mice develop multicentric lymphosarcoma associated with leukemia

immune system
• two-fold
• mice exhibit an increased in the number of lymphoblasts in lymph tissues and the blood compared to wild-type mice
• white blood cell counts are increased
• bone marrow from 5 week old mice contains an accumulation of pre-B cells

hematopoietic system
• two-fold
• mice exhibit an increased in the number of lymphoblasts in lymph tissues and the blood compared to wild-type mice
• white blood cell counts are increased
• bone marrow from 5 week old mice contains an accumulation of pre-B cells

endocrine/exocrine glands

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Burkitt lymphoma DOID:8584 OMIM:113970
J:78177 , J:186117




Genotype
MGI:4940207
tg57
Allelic
Composition
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean mortality is 19 weeks

neoplasm




Genotype
MGI:3711764
tg58
Allelic
Composition
Tg(IghMyc)22Bri/?
Genetic
Background
involves: C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

mortality/aging
• mean survival after lymphomas develop 91 days

neoplasm
• 6 of 6 mice suffer from dissemination disease with diffuse bone marrow infiltration of B220+ lymphocytes and infiltration of the spleen, liver and meninges

immune system

hematopoietic system





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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory