Mdm4^tm1Glo
Targeted Allele Detail

Summary

• Symbol: Mdm4^tm1Glo
• Name: transformed mouse 3T3 cell double minute 4; targeted mutation 1, Guillermina Lozano
• MGI ID: MGI:2183485
• Synonyms: Mdm4^-, Mdm4^delta3-5
• Gene: Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
• Alliance: Mdm4^tm1Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71532
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5 were replaced with a neomycin selection cassette. The deleted region encoded the majority of the Trp53-binding domain (amino acids 27-96). Aberrant splicing around the neo transgene would result in a frameshift mutation. Protein was undetected in homozygous mutant mice by Western blot analysis. (J:71532)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mdm4^tm1Glo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm4 Mutation: 190 strains or lines available

References

• Original: J:71532 Parant J, et al., Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet. 2001 Sep;29(1):92-5
• All: 17 reference(s)