Cks1b^tm1Sir
Targeted Allele Detail

Summary

• Symbol: Cks1b^tm1Sir
• Name: CDC28 protein kinase 1b; targeted mutation 1, Steven I Reed
• MGI ID: MGI:3711167
• Synonyms: Cks1^-
• Gene: Cks1b Location: Chr3:89322779-89325598 bp, - strand Genetic Position: Chr3, 39.11 cM
• Alliance: Cks1b^tm1Sir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121692
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2, which encodes 55% of the protein, was replaced with a neomycin resistance cassette. (J:121692)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cks1b Mutation: 11 strains or lines available

References

• Original: J:121692 Spruck C, et al., A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell. 2001 Mar;7(3):639-50
• All: 8 reference(s)