Phenotypes associated with this allele

• Allele Symbol: Cks1b^tm1Sir
• Allele Name: targeted mutation 1, Steven I Reed
• Allele ID: MGI:3711167
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cks1b^tm1Sir/Cks1b^tm1Sir	Not Specified	MGI:3711761
ht2	Cks1b^tm1Sir/Cks1b^+	Not Specified	MGI:3711762
cx3	Cks1b^tm1Sir/Cks1b^tm1Sir Tg(IghMyc)22Bri/?	involves: C57BL * C57BL/6 * SJL	MGI:3711763
cx4	Cks1b^tm1Sir/Cks1b^+ Tg(IghMyc)22Bri/?	involves: C57BL * C57BL/6 * SJL	MGI:3711765

Genotype
MGI:3711761

hm1

• Allelic Composition: Cks1b^tm1Sir/Cks1b^tm1Sir
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:121692 )

N • males and females are fertile

growth/size/body

decreased body weight ( J:121692 )

• mice are about 10% to 20% smaller than wild-type at E13.5 and continuing through adulthood

cellular

early cellular replicative senescence ( J:121692 )

• derived MEF cells grow slower and senesced earlier than wild-type MEFs

Genotype
MGI:3711762

ht2

• Allelic Composition: Cks1b^tm1Sir/Cks1b⁺
• Genetic Background: Not Specified

growth/size/body

decreased body weight ( J:121692 )

• intermediate decrease in body weight compared to Cks1b^tm1Sir homozygotes first noticeable during embryogenesis though to a lesser extent

Genotype
MGI:3711763

cx3

• Allelic Composition: Cks1b^tm1Sir/Cks1b^tm1Sir; Tg(IghMyc)22Bri/?
• Genetic Background: involves: C57BL * C57BL/6 * SJL

mortality/aging

premature death ( J:121564 )

• mean survival after lymphomas develop is 268 days compared to 91 days in Tg(IghMyc)22Bri mice and 101 days in Tg(IghMyc)22Bri Cks1b^tm1Sir heterozygotes

neoplasm

decreased metastatic potential ( J:121564 )

• only 1 of 9 diseased mice show moderate bone marrow infiltration and none presented with liver or meningeal infiltrates present in Tg(IghMyc)22Bri mice

increased lymphoma incidence ( J:121564 )

• delayed development of lymphomas compared to Tg(IghMyc)22Bri mice

immune system

decreased B cell proliferation ( J:121564 )

• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice

decreased leukocyte cell number ( J:121564 )

decreased lymphocyte cell number ( J:121564 )

• 5.4+/-0.4x10⁶ul compared to 6.9+/-0.4x10⁶ul in Tg(IghMyc)22Bri mice

decreased spleen weight ( J:121564 )

• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)

hematopoietic system

decreased B cell proliferation ( J:121564 )

• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice

decreased leukocyte cell number ( J:121564 )

decreased lymphocyte cell number ( J:121564 )

• 5.4+/-0.4x10⁶ul compared to 6.9+/-0.4x10⁶ul in Tg(IghMyc)22Bri mice

decreased spleen weight ( J:121564 )

• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)

cellular

decreased B cell proliferation ( J:121564 )

• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice

Genotype
MGI:3711765

cx4

• Allelic Composition: Cks1b^tm1Sir/Cks1b⁺; Tg(IghMyc)22Bri/?
• Genetic Background: involves: C57BL * C57BL/6 * SJL

mortality/aging

premature death ( J:121564 )

• mean survival after lymphomas development is 101 days

neoplasm

increased lymphoma incidence ( J:121564 )