Cul9^tm1.2Yxi
Targeted Allele Detail

Summary

• Symbol: Cul9^tm1.2Yxi
• Name: cullin 9; targeted mutation 1.2, Yue Xiong
• MGI ID: MGI:5007737
• Gene: Cul9 Location: Chr17:46811535-46857314 bp, - strand Genetic Position: Chr17, 22.9 cM
• Alliance: Cul9^tm1.2Yxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170976
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Cre-medited recombination removed exons 2 through 7 from Cul9^tm1.1Yxi. The absence of protein expression was confirmed by western blot analysis. (J:170976)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cul9^tm1.2Yxi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul9 Mutation: 108 strains or lines available

References

• Original: J:170976 Pei XH, et al., Cytoplasmic CUL9/PARC Ubiquitin Ligase Is a Tumor Suppressor and Promotes p53-Dependent Apoptosis. Cancer Res. 2011 Apr 15;71(8):2969-77
• All: 4 reference(s)