Kat5^tm1Jwl
Targeted Allele Detail

Summary

• Symbol: Kat5^tm1Jwl
• Name: K(lysine) acetyltransferase 5; targeted mutation 1, John W Lough
• MGI ID: MGI:3526095
• Synonyms: Tip60^-
• Gene: Kat5 Location: Chr19:5653042-5660265 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Kat5^tm1Jwl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125164
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector replaced 2,787 bp, including 193 bp of the promoter and exons 1-9, with the neomycin-resistance cassette in reverse orientation. (J:125164, J:153728)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat5 Mutation: 25 strains or lines available

References

• Original: J:125164 Gorrini C, et al., Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature. 2007 Aug 30;448(7157):1063-7
• All: 7 reference(s)