• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

• mammary gland tumors express more podoplanin+ lymphatic endothelial cells than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice

• intratumoral lyphatics are 16-fold greater than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice while peritumoral lymphatic vessels are only 1.5-fold greater

• tumor lymphatic vessels are associated with high hyaluronan stroma

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

• considerably accelerated tumor development

• normal mammary development and normal lactation (J:82321)

• decreased percentage of double positive cells

• increased percentage of CD8-SP thymocytes

• 59% of mice develop fatal T-cell lymphomas between 3 and 9 months of age

• remaining animals continue healthy past 10 months of age

• decreased percentage of double positive cells

• increased percentage of CD8-SP thymocytes

• decreased percentage of double positive cells

• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow

• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells

• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal

• absolute numbers of all hematopoietic cell lineages are reduced to varying degrees

• however the frequencies of CD3+ T and CD4+ T lymphocytes, Gr1+CD11b+ myeloid cells, Ter119+ erythrocytes, and CD41+Ter119^- megakaryocytes are largely normal or elevated in various tissues

• dramatic decrease in the percentage of B220+ CD19+ B cells in the bone marrow, spleen, peripheral blood, and lymph nodes compared to littermate controls

• marked reduction the number of peripheral B cells that express surface IgM and IgD mice have only 0.25% of control B cell numbers

• reduction in the number and frequency of pre-pro-B cells in the bone marrow

• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow

• most cells in the CLP population are Ly6D^- all-lymphoid progenitors with only a few Ly6D+ B cell biased lymphoid progenitors detected

• truncated tail

• reduction in the number and frequency of pre-pro-B cells in the bone marrow

• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow

• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow

• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells

• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal

• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow

• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells

• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal

• dramatic decrease in the percentage of B220+ CD19+ B cells in the bone marrow, spleen, peripheral blood, and lymph nodes compared to littermate controls

• marked reduction the number of peripheral B cells that express surface IgM and IgD mice have only 0.25% of control B cell numbers

• reduction in the number and frequency of pre-pro-B cells in the bone marrow

• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow

• most cells in the CLP population are Ly6D^- all-lymphoid progenitors with only a few Ly6D+ B cell biased lymphoid progenitors detected

• mice exhibit normal salivary gland morphology (J:153070)

• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice

• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice

• most die early with lymphoma/thymoma

• some mice have small mammary tumors

• survival is reduced compared to mutant mice wild-type for Trp53

• at a lower rate than in mutant mice homozygous for Trp53^tm1Brn

• 80% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma

• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

• compared with control mice

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

• mammary ductal outgrowth arrested at prepubertal stage (J:124962)

• little ductal invasion of fat pad at 6 months (J:124962)

• minimal side branching (J:124962)

• mammary ductal outgrowth arrested at prepubertal stage (J:124962)

• little ductal invasion of fat pad at 6 months (J:124962)

• minimal side branching (J:124962)

• mice exhibit normal mammary gland formation throughout puberty (J:170904)

• reduction in the proportion of IL-17-producing T cells after polyclonally stimulated for 3 days in media alone or under optimal Th17 conditions in vitro

• reduction in the proportion of IL-17-producing T cells after polyclonally stimulated for 3 days in media alone or under optimal Th17 conditions in vitro

• unexpectedly, no lymphomas developed for at least the first year of life (J:105505)

• 92% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or poorly differentiated adenocarcinoma

• at 1 to 5 months of age, mice begin to develop skin tumors on their faces

• 3 weeks after birth

• in the dorsal epidermis

• at 1 to 5 months of age, mice begin to develop skin tumors on their faces

• male and female mice are born in normal Mendelian ratios (J:165550)

• authors state that mice exhibit a phenotype identical to Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(KRT14-cre)8Brn mice

• authors state that mice exhibit a phenotype identical to Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(KRT14-cre)8Brn mice

• authors state that mice exhibit a phenotype identical to Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(KRT14-cre)8Brn mice

• submandibular gland hyperplasia is seen in mutant mice

• submandibular gland hyperplasia is seen in mutant mice

• 60% exhibit an occasional cyst on the surface of the kidney at 10 weeks of age and 100% have kidney cysts at 20 weeks of age

• 20% exhibit an occasional cyst on the surface of the liver at 10 weeks of age and 100% have multiple hepatic cysts at 20 weeks of age

• virgin mammary ducts develop excessive side branches or small protrusions at 6 weeks of age (J:78415)

• delay in the normal involution process and a decrease in cell apoptosis (J:78415)

• mammary glands exhibit much larger lobules on the 13th day of pregnancy (J:78415)

• mammary ducts grow much faster during puberty than in controls, leading to earlier occupancy of the fat pad and earlier disappearance of the terminal end buds than in controls (J:78415)

• virgin mammary duct epithelium exhibits increased proliferation at 5 weeks and 14 weeks of age (J:78415)

• virgin glands contain many lobuloalveolar buds which are normally seen during pregnancy indicating an acceleration in lobuloalveolar-like precocious differentiation (J:78415)

• mammary glands after one pregnancy show intra-luminal focal cellular hyperplasia and dysplasia (J:78415)

• mammary glands exhibit much larger lobules on the 13th day of pregnancy (J:78415)

• develop mammary gland tumors as early as 2 months of age

• tumor incidence is increased with shortened latencies in multiparous females

• benign fibroadenomas

• pleiomorphic adenocarcinomas

• virgin mammary ducts develop excessive side branches or small protrusions at 6 weeks of age (J:78415)

• delay in the normal involution process and a decrease in cell apoptosis (J:78415)

• mammary glands exhibit much larger lobules on the 13th day of pregnancy (J:78415)

• mammary ducts grow much faster during puberty than in controls, leading to earlier occupancy of the fat pad and earlier disappearance of the terminal end buds than in controls (J:78415)

• virgin mammary duct epithelium exhibits increased proliferation at 5 weeks and 14 weeks of age (J:78415)

• virgin glands contain many lobuloalveolar buds which are normally seen during pregnancy indicating an acceleration in lobuloalveolar-like precocious differentiation (J:78415)

• mammary glands after one pregnancy show intra-luminal focal cellular hyperplasia and dysplasia (J:78415)

• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen (J:132088)

• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to mutants with wild-type Trp53 and also an increase in the percentage of mice with hyperplastic alveolar nodules (J:132088)

• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

• cancers are Esr1-negative

• mutants develop mammary gland preneoplasia that are Esr1-negative

• 25% of mutants develop ureteral obstruction 1-3 months after estrogen pellet placement

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen (J:132088)

• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to mutants with wild-type Trp53 and also an increase in the percentage of mice with hyperplastic alveolar nodules (J:132088)

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen (J:132088)

• mutants develop hyperplastic alveolar nodules (J:132088)

• 100% of mutants develop invasive mammary cancer

• some cancers are Esr1-negative while others are Esr1-positive

• mutants develop mammary gland preneoplasia

• some preneoplasia are Esr1-negative while others are Esr1-positive

• mutants develop hyperplastic alveolar nodules (J:132088)

• at pregnancy day 8.5, mammary glands are smaller than controls (J:54533)

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants (J:54533)

• 3 of 10 female mice developed mammary tumors of diverse types

• developmental defects may correlate with apoptosis observed in mutant mammary glands (J:54533)

• abnormal ductal morphogenesis was observed at lactation and involution (J:54533)

• residual alveolar structures sometimes remain in involuting mammary glands (J:54533)

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants (J:54533)

• at pregnancy day 8.5, mammary glands are smaller than controls (J:54533)

• developmental defects may correlate with apoptosis observed in mutant mammary glands (J:54533)

• abnormal ductal morphogenesis was observed at lactation and involution (J:54533)

• residual alveolar structures sometimes remain in involuting mammary glands (J:54533)

• at pregnancy day 8.5, mammary glands are smaller than controls (J:54533)

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants (J:54533)

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk (J:92770)

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing (J:92770)

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females (J:92770)

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk (J:92770)

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing (J:92770)

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females (J:92770)

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk (J:92770)

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk (J:92770)

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing (J:92770)

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females (J:92770)

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk (J:92770)

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing (J:92770)

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females (J:92770)

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk (J:92770)

• by 14 months of age

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen (J:132088)

• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice (J:132088)

• mammary glands exhibit longer ductal extension during puberty (6 weeks of age) (J:132088)

• 3 week old mutants exposed to continuous exogenous estrogen and progesterone for 2 weeks exhibit impaired terminal end bud differentiation into terminal ductal ends unlink wild-type mice (J:132088)

• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to controls and also an increase in the percentage of mice with hyperplastic alveolar nodules (J:132088)

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen (J:132088)

• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice (J:132088)

• mammary glands exhibit longer ductal extension during puberty (6 weeks of age) (J:132088)

• 3 week old mutants exposed to continuous exogenous estrogen and progesterone for 2 weeks exhibit impaired terminal end bud differentiation into terminal ductal ends unlink wild-type mice (J:132088)

• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to controls and also an increase in the percentage of mice with hyperplastic alveolar nodules (J:132088)

• 71% of mutants develop ureteral obstruction 1-5 months after estrogen pellet placement

• 14% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen (J:132088)

• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice (J:132088)

• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion

• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes

• tumors display ductal enlargement that may or may not be pre-existing

• involution is delayed at I2, I5, and I16 (J:110115)

• apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice (J:110115)

• apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis (J:110115)

• during involution after weaning, mice display enlarged ducts (J:110115)

• after involution ducts remain enlarged (J:110115)

• nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice (J:110115)

• involution is delayed at I2, I5, and I16 (J:110115)

• apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice (J:110115)

• apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis (J:110115)

• during involution after weaning, mice display enlarged ducts (J:110115)

• after involution ducts remain enlarged (J:110115)

• nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice (J:110115)

• survival time is increased compared to mutant mice carrying Tg(MMTV-cre)1Mam

• develop a less diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)1Mam

• start to develop by 5 months of age in both virgin and multiparous mice

• 69% of mice have palpable mammary tumors at the time of death

• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

• isolated lung metastases are seen in rare cases

• mammary glands have reduced numbers of epithelial cells (J:87469)

• some epithelial cells remain condensed and disorganized without forming alveolar structures (J:87469)

• lumens are absent from clusters of epithelium (J:87469)

• milk proteins are reduced (J:87469)

• apoptosis in mammary epithelium is increased (J:87469)

• mammary glands have reduced numbers of epithelial cells (J:87469)

• some epithelial cells remain condensed and disorganized without forming alveolar structures (J:87469)

• lumens are absent from clusters of epithelium (J:87469)

• milk proteins are reduced (J:87469)

• apoptosis in mammary epithelium is increased (J:87469)

• occasionally hair development is not on schedule

• mice have normal mammary gland development (J:76553)

• the expected number of mice are born but very few survive, no time of lethality provided

• surviving females display poorly developed mammary epithelial structures (J:148362)

• surviving females display severe lactation defects (J:148362)

• surviving females display poorly developed mammary epithelial structures (J:148362)

• surviving females display severe lactation defects (J:148362)

• developed in 6 out of 10 females tested

• tumor latency ranged from 6 months to 20 months

• 81% of pups nursed by mothers carrying this transgene survive to weaning

• pups nursed by mothers carrying this transgene are smaller than those nursed by control mothers but not statistically

• mammary gland development checked at the end of lactation was highly variable among mice (J:168531)

• cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter was not initiated until about 3 weeks of age (J:168531)

• cre expression shows a high level of mosaicism initially but complete deletion was observed in older mice (J:168531)

• mammary gland development checked at the end of lactation was highly variable among mice (J:168531)

• cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter was not initiated until about 3 weeks of age (J:168531)

• cre expression shows a high level of mosaicism initially but complete deletion was observed in older mice (J:168531)