About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MMTV-cre)4Mam
transgene insertion 4, Lothar Hennighausen
MGI:2176166
Summary 35 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(CAG-Has2)99Nita/0
Tg(MMTV-cre)4Mam/0
Tg(MMTVneu)202Mul/0
FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul MGI:4839392
cn2
Cdkn1btm1Mlf/Cdkn1b+
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
involves: 129 * C57BL/6 * CBA * FVB MGI:3618584
cn3
n-TUtca2tm1Dhat/n-TUtca2tm1Dhat
Tg(MMTV-cre)4Mam/0
involves: 129 * C57BL/6 * FVB MGI:2655308
cn4
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
involves: 129 * C57BL/6 * FVB MGI:3618583
cn5
Mysm1tm1a(KOMP)Wtsi/Mysm1tm1a(KOMP)Wtsi
Tg(MMTV-cre)4Mam/0
involves: 129 * C57BL/6N * FVB/N MGI:5311943
cn6
St14tm2Bug/St14tm3Bug
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * FVB MGI:4361220
cn7
St14tm2Bug/St14tm3Bug
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss MGI:5634327
cn8
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(MMTV-cre)4Mam/0
Tg(MMTV-Erbb2)1Pv/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N MGI:4948967
cn9
Esr1tm1Sakh/Esr1tm1Sakh
Tg(MMTV-cre)4Mam/?
involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:4459316
cn10
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:4948966
cn11
Stat3tm1Dlv/Stat3tm1Dlv
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * C57BL/6J * FVB MGI:4843432
cn12
Ep300tm2Pkb/Ep300tm2Pkb
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * FVB MGI:3618540
cn13
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Tg(MMTV-cre)4Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB MGI:5517429
cn14
Chuktm1Yhu/Chuktm1Yhu
Tg(MMTV-cre)4Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB MGI:3817625
cn15
Rlimtm1.1Inba/Rlimtm1.1Inba
Tg(MMTV-cre)4Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB MGI:4838163
cn16
Grhl3tm1Jane/Grhl3tm3.1Jane
Tg(MMTV-cre)4Mam/0
involves: 129S1/Sv * C57BL/6 * FVB MGI:5306660
cn17
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(MMTV-cre)4Mam/0
involves: 129S4/SvJae * FVB MGI:3617392
cn18
Krastm4Tyj/Kras+
Tg(MMTV-cre)4Mam/0
involves: 129S4/SvJae * FVB MGI:3044680
cn19
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)4Mam/0
involves: 129S4/SvJae * FVB MGI:4829793
cn20
Brca1tm1Cxd/Brca1tm2Cxd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB MGI:2176786
cn21
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Trp53tm1Brd/Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB MGI:5297134
cn22
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB MGI:5297135
cn23
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB MGI:3055366
cn24
Brca1tm1Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB MGI:2176785
cn25
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB MGI:3055363
cn26
Sav1tm1.1Rjo/Sav1tm1.1Rjo
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL MGI:4430545
cn27
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:5297133
cn28
Mnttm1Awb/Mnttm1.1Awb
Tg(MMTV-cre)4Mam/?
involves: 129S6/SvEvTac * FVB/N MGI:3718675
cn29
Ctnna1tm1Efu/Ctnna1tm1Efu
Tg(MMTV-cre)4Mam/?
involves: 129X1/SvJ * FVB MGI:3720649
cn30
Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)4Mam/?
involves: 129X1/SvJ * FVB MGI:3722294
cn31
Elf5tm1Sin/Elf5tm1Sin
Tg(MMTV-cre)4Mam/0
involves: C57BL/6 * FVB MGI:3844573
cn32
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+
Tg(MMTV-cre)4Mam/0
involves: C57BL/6J * C57BL/6N * FVB/N MGI:5517430
cn33
Mnttm1Phu/Mnttm1Phu
Tg(MMTV-cre)4Mam/?
involves: FVB MGI:2678344
cx34
Brca1tm2Cxd/Brca1tm2Cxd
Pkmtm1.1Mgvh/Pkmtm1.1Mgvh
Tg(MMTV-cre)4Mam/0
Trp53tm1Brd/Trp53+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:5547937
tg35
Tg(MMTV-cre)4Mam/? involves: FVB MGI:4888635


Genotype
MGI:4839392
cn1
Allelic
Composition
Tg(CAG-Has2)99Nita/0
Tg(MMTV-cre)4Mam/0
Tg(MMTVneu)202Mul/0
Genetic
Background
FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Has2)99Nita mutation (0 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTVneu)202Mul mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

endocrine/exocrine glands

neoplasm

hematopoietic system
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

immune system
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control
• mammary gland tumors express more podoplanin+ lymphatic endothelial cells than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice
• intratumoral lyphatics are 16-fold greater than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice while peritumoral lymphatic vessels are only 1.5-fold greater
• tumor lymphatic vessels are associated with high hyaluronan stroma

cellular
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:164205




Genotype
MGI:3618584
cn2
Allelic
Composition
Cdkn1btm1Mlf/Cdkn1b+
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Mlf mutation (2 available); any Cdkn1b mutation (15 available)
Crebbptm1Jvd mutation (2 available); any Crebbp mutation (56 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• considerably accelerated tumor development

neoplasm
• considerably accelerated tumor development




Genotype
MGI:2655308
cn3
Allelic
Composition
n-TUtca2tm1Dhat/n-TUtca2tm1Dhat
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TUtca2tm1Dhat mutation (0 available); any n-TUtca2 mutation (2 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• normal mammary development and normal lactation




Genotype
MGI:3618583
cn4
Allelic
Composition
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Jvd mutation (2 available); any Crebbp mutation (56 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 59% of mice develop fatal T-cell lymphomas between 3 and 9 months of age
• remaining animals continue healthy past 10 months of age

immune system
• decreased percentage of double positive cells
• increased percentage of CD8-SP thymocytes

neoplasm
• 59% of mice develop fatal T-cell lymphomas between 3 and 9 months of age
• remaining animals continue healthy past 10 months of age

hematopoietic system
• decreased percentage of double positive cells
• increased percentage of CD8-SP thymocytes




Genotype
MGI:5311943
cn5
Allelic
Composition
Mysm1tm1a(KOMP)Wtsi/Mysm1tm1a(KOMP)Wtsi
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129 * C57BL/6N * FVB/N
Cell Lines EPD0019_1_A04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1tm1a(KOMP)Wtsi mutation (1 available); any Mysm1 mutation (20 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow
• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells
• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal
• most cells in the CLP population are Ly6D- all-lymphoid progenitors with only a few Ly6D+ B cell biased lymphoid progenitors detected
• absolute numbers of all hematopoietic cell lineages are reduced to varying degrees
• however the frequencies of CD3+ T and CD4+ T lymphocytes, Gr1+CD11b+ myeloid cells, Ter119+ erythrocytes, and CD41+Ter119- megakaryocytes are largely normal or elevated in various tissues
• dramatic decrease in the percentage of B220+ CD19+ B cells in the bone marrow, spleen, peripheral blood, and lymph nodes compared to littermate controls
• marked reduction the number of peripheral B cells that express surface IgM and IgD mice have only 0.25% of control B cell numbers
• reduction in the number and frequency of pre-pro-B cells in the bone marrow
• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow

growth/size/body

limbs/digits/tail
• truncated tail

immune system
• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow
• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells
• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal
• dramatic decrease in the percentage of B220+ CD19+ B cells in the bone marrow, spleen, peripheral blood, and lymph nodes compared to littermate controls
• marked reduction the number of peripheral B cells that express surface IgM and IgD mice have only 0.25% of control B cell numbers
• reduction in the number and frequency of pre-pro-B cells in the bone marrow
• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow




Genotype
MGI:4361220
cn6
Allelic
Composition
St14tm2Bug/St14tm3Bug
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St14tm2Bug mutation (0 available); any St14 mutation (22 available)
St14tm3Bug mutation (0 available); any St14 mutation (22 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• mice exhibit normal salivary gland morphology
• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice

endocrine/exocrine glands
• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice

homeostasis/metabolism
• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice




Genotype
MGI:5634327
cn7
Allelic
Composition
St14tm2Bug/St14tm3Bug
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St14tm2Bug mutation (0 available); any St14 mutation (22 available)
St14tm3Bug mutation (0 available); any St14 mutation (22 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• increase in lymphocytic infiltration area in the submandibular gland
• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

endocrine/exocrine glands
• increase in lymphocytic infiltration area in the submandibular gland
• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine
• increase in lymphocytic infiltration area in the lacrimal gland

hematopoietic system
• the percentage of CD25+Foxp3+ cells within the CD4+ T cell population is increased in the salivary gland draining lymph nodes
• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells
• decrease in the number and percentage of CD4+ cells among salivary gland draining lymph node cells and splenocytes
• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells
• decrease in the number and percentage of CD8+ cells among salivary gland draining lymph node cells and splenocytes
• total number of Treg cells in the salivary gland draining lymph node is decreased
• decrease in the CD4+CD25+Foxp3+ Treg cell population in spleens

homeostasis/metabolism
• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

immune system
• increase in lymphocytic infiltration area in the submandibular gland
• increase in lymphocytic infiltration area in the lacrimal gland
• the percentage of CD25+Foxp3+ cells within the CD4+ T cell population is increased in the salivary gland draining lymph nodes
• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells
• decrease in the number and percentage of CD4+ cells among salivary gland draining lymph node cells and splenocytes
• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells
• decrease in the number and percentage of CD8+ cells among salivary gland draining lymph node cells and splenocytes
• total number of Treg cells in the salivary gland draining lymph node is decreased
• decrease in the CD4+CD25+Foxp3+ Treg cell population in spleens
• cytokine production is increased in local and systemic immune system
• mice exhibit an increase in IL-1beta, IL-4, IL-5, IL-, IL-10, IL-12-40, IL-13, IL-17, and IFN-gamma cytokines released from cells isolated from salivary gland salivary gland draining lymph node
• cultured splenocytes exhibit an increase in proinflammatory T/B cytokines and a decrease in the Th2 polarizing cytokine IL-4
• increase in proinflammatory cytokines is seen in the serum
• cultured splenocytes exhibit an increase in production of MCP-1, MCP-5, MIP-1beta, RANTES and MMP-9 chemokines
• increase in proinflammatory chemokines is seen in the serum
• increase in serum levels of anti-SSA/Ro (multiple antigenic peptide (MAP)-Ro273), anti-SSB/La and anti-nuclear antibodies

vision/eye
• increase in lymphocytic infiltration area in the lacrimal gland
• tear flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:213072




Genotype
MGI:4948967
cn8
Allelic
Composition
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(MMTV-cre)4Mam/0
Tg(MMTV-Erbb2)1Pv/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7tm1.1Twad mutation (0 available); any Map2k7 mutation (6 available)
Map2k7tm1.2Twad mutation (0 available); any Map2k7 mutation (6 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-Erbb2)1Pv mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compared with control mice

neoplasm
• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

integument
• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

endocrine/exocrine glands
• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice




Genotype
MGI:4459316
cn9
Allelic
Composition
Esr1tm1Sakh/Esr1tm1Sakh
Tg(MMTV-cre)4Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1Sakh mutation (0 available); any Esr1 mutation (22 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mammary ductal outgrowth arrested at prepubertal stage
• little ductal invasion of fat pad at 6 months
• minimal side branching

integument
• mammary ductal outgrowth arrested at prepubertal stage
• little ductal invasion of fat pad at 6 months
• minimal side branching




Genotype
MGI:4948966
cn10
Allelic
Composition
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7tm1.1Twad mutation (0 available); any Map2k7 mutation (6 available)
Map2k7tm1.2Twad mutation (0 available); any Map2k7 mutation (6 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice exhibit normal mammary gland formation throughout puberty




Genotype
MGI:4843432
cn11
Allelic
Composition
Stat3tm1Dlv/Stat3tm1Dlv
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Dlv mutation (0 available); any Stat3 mutation (43 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduction in the proportion of IL-17-producing T cells after polyclonally stimulated for 3 days in media alone or under optimal Th17 conditions in vitro

immune system
• reduction in the proportion of IL-17-producing T cells after polyclonally stimulated for 3 days in media alone or under optimal Th17 conditions in vitro




Genotype
MGI:3618540
cn12
Allelic
Composition
Ep300tm2Pkb/Ep300tm2Pkb
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300tm2Pkb mutation (2 available); any Ep300 mutation (44 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• unexpectedly, no lymphomas developed for at least the first year of life




Genotype
MGI:5517429
cn13
Allelic
Composition
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Jus mutation (0 available); any Gt(ROSA)26Sor mutation (343 available)
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (4 available); any Gt(ROSA)26Sor mutation (343 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• expanded long term hematopoietic stem-like cells




Genotype
MGI:3817625
cn14
Allelic
Composition
Chuktm1Yhu/Chuktm1Yhu
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (21 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 1 to 5 months of age, mice begin to develop skin tumors on their faces

integument
• 3 weeks after birth
• in the dorsal epidermis
• at 1 to 5 months of age, mice begin to develop skin tumors on their faces




Genotype
MGI:4838163
cn15
Allelic
Composition
Rlimtm1.1Inba/Rlimtm1.1Inba
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rlimtm1.1Inba mutation (0 available); any Rlim mutation (14 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• male and female mice are born in normal Mendelian ratios




Genotype
MGI:5306660
cn16
Allelic
Composition
Grhl3tm1Jane/Grhl3tm3.1Jane
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1Jane mutation (0 available); any Grhl3 mutation (37 available)
Grhl3tm3.1Jane mutation (0 available); any Grhl3 mutation (37 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• authors state that mice exhibit a phenotype identical to Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre)8Brn mice
• authors state that mice exhibit a phenotype identical to Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre)8Brn mice

neoplasm
• authors state that mice exhibit a phenotype identical to Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre)8Brn mice




Genotype
MGI:3617392
cn17
Allelic
Composition
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S4/SvJae * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Ggg mutation (1 available); any Pkd1 mutation (68 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• 60% exhibit an occasional cyst on the surface of the kidney at 10 weeks of age and 100% have kidney cysts at 20 weeks of age

liver/biliary system
• 20% exhibit an occasional cyst on the surface of the liver at 10 weeks of age and 100% have multiple hepatic cysts at 20 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 1; PKD1 173900 J:103719




Genotype
MGI:3044680
cn18
Allelic
Composition
Krastm4Tyj/Kras+
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S4/SvJae * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• submandibular gland hyperplasia is seen in mutant mice

digestive/alimentary system
• submandibular gland hyperplasia is seen in mutant mice




Genotype
MGI:4829793
cn19
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S4/SvJae * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (41 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls
• transplants from virgins exhibit focal ductal hyperplasia containing papillary structure
• after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

integument
• transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls
• transplants from virgins exhibit focal ductal hyperplasia containing papillary structure
• after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

Mouse Models of Human Disease
OMIM ID Ref(s)
Cowden Syndrome 1; CWS1 158350 J:78415




Genotype
MGI:2176786
cn20
Allelic
Composition
Brca1tm1Cxd/Brca1tm2Cxd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (75 available)
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (75 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

integument
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

neoplasm
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies




Genotype
MGI:5297134
cn21
Allelic
Composition
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (75 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen
• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to mutants with wild-type Trp53 and also an increase in the percentage of mice with hyperplastic alveolar nodules
• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen
• cancers are Esr1-negative

neoplasm
• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen
• cancers are Esr1-negative
• mutants develop mammary gland preneoplasia that are Esr1-negative

renal/urinary system
• 25% of mutants develop ureteral obstruction 1-3 months after estrogen pellet placement

integument
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen
• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to mutants with wild-type Trp53 and also an increase in the percentage of mice with hyperplastic alveolar nodules
• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen
• cancers are Esr1-negative

cellular
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen




Genotype
MGI:5297135
cn22
Allelic
Composition
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (75 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Esr1)#Paf mutation (0 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mutants develop hyperplastic alveolar nodules
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive

neoplasm
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive
• mutants develop mammary gland preneoplasia
• some preneoplasia are Esr1-negative while others are Esr1-positive

integument
• mutants develop hyperplastic alveolar nodules
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive




Genotype
MGI:3055366
cn23
Allelic
Composition
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5btm1Mam mutation (0 available); any Stat5b mutation (14 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk
• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing
• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

integument
• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk
• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing
• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

behavior/neurological
• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk




Genotype
MGI:2176785
cn24
Allelic
Composition
Brca1tm1Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (75 available)
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (75 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

neoplasm
• 3 of 10 female mice developed mammary tumors of diverse types

endocrine/exocrine glands
• developmental defects may correlate with apoptosis observed in mutant mammary glands
• abnormal ductal morphogenesis was observed at lactation and involution
• residual alveolar structures sometimes remain in involuting mammary glands
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants
• 3 of 10 female mice developed mammary tumors of diverse types

integument
• developmental defects may correlate with apoptosis observed in mutant mammary glands
• abnormal ductal morphogenesis was observed at lactation and involution
• residual alveolar structures sometimes remain in involuting mammary glands
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants
• 3 of 10 female mice developed mammary tumors of diverse types




Genotype
MGI:3055363
cn25
Allelic
Composition
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (22 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (14 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk
• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing
• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

integument
• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk
• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing
• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

behavior/neurological
• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk




Genotype
MGI:4430545
cn26
Allelic
Composition
Sav1tm1.1Rjo/Sav1tm1.1Rjo
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Rjo mutation (0 available); any Sav1 mutation (9 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• by 14 months of age

neoplasm
• by 14 months of age




Genotype
MGI:5297133
cn27
Allelic
Composition
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (75 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen
• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice
• mammary glands exhibit longer ductal extension during puberty (6 weeks of age)
• 3 week old mutants exposed to continuous exogenous estrogen and progesterone for 2 weeks exhibit impaired terminal end bud differentiation into terminal ductal ends unlink wild-type mice
• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to controls and also an increase in the percentage of mice with hyperplastic alveolar nodules
• 14% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

integument
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen
• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice
• mammary glands exhibit longer ductal extension during puberty (6 weeks of age)
• 3 week old mutants exposed to continuous exogenous estrogen and progesterone for 2 weeks exhibit impaired terminal end bud differentiation into terminal ductal ends unlink wild-type mice
• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to controls and also an increase in the percentage of mice with hyperplastic alveolar nodules
• 14% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

renal/urinary system
• 71% of mutants develop ureteral obstruction 1-5 months after estrogen pellet placement

neoplasm
• 14% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

cellular
• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen
• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice




Genotype
MGI:3718675
cn28
Allelic
Composition
Mnttm1Awb/Mnttm1.1Awb
Tg(MMTV-cre)4Mam/?
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnttm1.1Awb mutation (0 available); any Mnt mutation (19 available)
Mnttm1Awb mutation (1 available); any Mnt mutation (19 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion
• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes
• tumors display ductal enlargement that may or may not be pre-existing

endocrine/exocrine glands
• involution is delayed at I2, I5, and I16
• apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice
• apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis
• during involution after weaning, mice display enlarged ducts
• after involution ducts remain enlarged
• nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice
• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion
• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes
• tumors display ductal enlargement that may or may not be pre-existing

integument
• involution is delayed at I2, I5, and I16
• apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice
• apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis
• during involution after weaning, mice display enlarged ducts
• after involution ducts remain enlarged
• nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice
• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion
• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes
• tumors display ductal enlargement that may or may not be pre-existing




Genotype
MGI:3720649
cn29
Allelic
Composition
Ctnna1tm1Efu/Ctnna1tm1Efu
Tg(MMTV-cre)4Mam/?
Genetic
Background
involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1tm1Efu mutation (1 available); any Ctnna1 mutation (120 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mammary glands have reduced numbers of epithelial cells
• some epithelial cells remain condensed and disorganized without forming alveolar structures
• lumens are absent from clusters of epithelium
• milk proteins are reduced
• apoptosis in mammary epithelium is increased
• apoptosis in mammary epithelium is increased

integument
• mammary glands have reduced numbers of epithelial cells
• some epithelial cells remain condensed and disorganized without forming alveolar structures
• lumens are absent from clusters of epithelium
• milk proteins are reduced
• apoptosis in mammary epithelium is increased
• apoptosis in mammary epithelium is increased
• occasionally hair development is not on schedule




Genotype
MGI:3722294
cn30
Allelic
Composition
Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)4Mam/?
Genetic
Background
involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (23 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice have normal mammary gland development




Genotype
MGI:3844573
cn31
Allelic
Composition
Elf5tm1Sin/Elf5tm1Sin
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5tm1Sin mutation (0 available); any Elf5 mutation (5 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the expected number of mice are born but very few survive, no time of lethality provided

endocrine/exocrine glands
• surviving females display poorly developed mammary epithelial structures
• surviving females display severe lactation defects

integument
• surviving females display poorly developed mammary epithelial structures
• surviving females display severe lactation defects




Genotype
MGI:5517430
cn32
Allelic
Composition
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Jus mutation (0 available); any Gt(ROSA)26Sor mutation (343 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 64 days

immune system
• in diseased mice
• lymphoid infiltration in the thymus at 6 months
• monomorphic, enlarged white blood cells with a high nuclear:chromatin ratio (consistent with leukemic blasts) at 6 months
• nearly all B cells are arrested in the early pro-B stage
• in the spleen
• immature single positive cells in the thymus
• large, unstained cells (abnormal blasts) in the peripheral blood at 6 months
• disrupted separation between white and red pulp by infiltrating lymphoblasts at 6 months
• in diseased mice
• in diseased mice
• lymphoid infiltration in the spleen, interstitial and perivascular space of the kidney, perivascular cuffs in the liver, meninges surrounding the brain, thymus, stomach and intestine at 6 months
• lymphoid infiltration in the intestine at 6 months
• lymphoid infiltration in the stomach at 6 months
• lymphoid infiltration in the meninges surrounding the brain at 6 months
• lymphoid infiltration in the perivascular cuffs in the liver at 6 months
• lymphoid infiltration in the interstitial and perivascular space of the kidney at 6 months

digestive/alimentary system
• lymphoid infiltration in the intestine at 6 months
• lymphoid infiltration in the stomach at 6 months

neoplasm
• mice rapidly develop and succumb to acute leukemia

behavior/neurological

growth/size/body
• in diseased mice

respiratory system

liver/biliary system
• lymphoid infiltration in the perivascular cuffs in the liver at 6 months
• in diseased mice

nervous system
• lymphoid infiltration in the meninges surrounding the brain at 6 months

renal/urinary system
• lymphoid infiltration in the interstitial and perivascular space of the kidney at 6 months
• in diseased mice

hematopoietic system
• in diseased mice
• lymphoid infiltration in the thymus at 6 months
• slightly at 6 months
• severely at 6 months
• monomorphic, enlarged white blood cells with a high nuclear:chromatin ratio (consistent with leukemic blasts) at 6 months
• nearly all B cells are arrested in the early pro-B stage
• in the spleen
• immature single positive cells in the thymus
• large, unstained cells (abnormal blasts) in the peripheral blood at 6 months
• disrupted separation between white and red pulp by infiltrating lymphoblasts at 6 months
• in diseased mice

endocrine/exocrine glands
• in diseased mice
• lymphoid infiltration in the thymus at 6 months




Genotype
MGI:2678344
cn33
Allelic
Composition
Mnttm1Phu/Mnttm1Phu
Tg(MMTV-cre)4Mam/?
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnttm1Phu mutation (0 available); any Mnt mutation (19 available)
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• developed in 6 out of 10 females tested
• tumor latency ranged from 6 months to 20 months

endocrine/exocrine glands
• developed in 6 out of 10 females tested
• tumor latency ranged from 6 months to 20 months

neoplasm
• developed in 6 out of 10 females tested
• tumor latency ranged from 6 months to 20 months




Genotype
MGI:5547937
cx34
Allelic
Composition
Brca1tm2Cxd/Brca1tm2Cxd
Pkmtm1.1Mgvh/Pkmtm1.1Mgvh
Tg(MMTV-cre)4Mam/0
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (75 available)
Pkmtm1.1Mgvh mutation (1 available); any Pkm mutation (60 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice

endocrine/exocrine glands
• mice develop breast tumors similar to control mice

integument
• mice develop breast tumors similar to control mice

mortality/aging
• accelerated tumor associated mortality relative to control mice

neoplasm
• mice develop breast tumors similar to control mice
• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice
• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice




Genotype
MGI:4888635
tg35
Allelic
Composition
Tg(MMTV-cre)4Mam/?
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)4Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 81% of pups nursed by mothers carrying this transgene survive to weaning
• pups nursed by mothers carrying this transgene are smaller than those nursed by control mothers but not statistically

endocrine/exocrine glands
• mammary gland development checked at the end of lactation was highly variable among mice
• cre expression as determined using Gt(ROSA)26Sortm1Sor as a reporter was not initiated until about 3 weeks of age
• cre expression shows a high level of mosaicism initially but complete deletion was observed in older mice

integument
• mammary gland development checked at the end of lactation was highly variable among mice
• cre expression as determined using Gt(ROSA)26Sortm1Sor as a reporter was not initiated until about 3 weeks of age
• cre expression shows a high level of mosaicism initially but complete deletion was observed in older mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory