All Phenotypes Tg(MMTV-cre)4Mam MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(MMTV-cre)4Mam
transgene insertion 4, Lothar Hennighausen
MGI:2176166

Summary

37 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-Has2)99Nita/0 Tg(MMTV-cre)4Mam/0 Tg(MMTVneu)202Mul/0	FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul	MGI:4839392
cn2	Cdkn1b^tm1Mlf/Cdkn1b⁺ Crebbp^tm1Jvd/Crebbp^tm1Jvd Tg(MMTV-cre)4Mam/0	involves: 129 * C57BL/6 * CBA * FVB	MGI:3618584
cn3	Crebbp^tm1Jvd/Crebbp^tm1Jvd Tg(MMTV-cre)4Mam/0	involves: 129 * C57BL/6 * FVB	MGI:3618583
cn4	Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb Tg(MMTV-cre)4Mam/0	involves: 129 * C57BL/6 * FVB	MGI:6303631
cn5	n-TUtca2^tm1Dhat/n-TUtca2^tm1Dhat Tg(MMTV-cre)4Mam/0	involves: 129 * C57BL/6 * FVB	MGI:2655308
cn6	Mysm1^{tm1b(KOMP)Wtsi}/Mysm1^{tm1b(KOMP)Wtsi} Tg(MMTV-cre)4Mam/0	involves: 129 * C57BL/6N * FVB/N	MGI:5311943
cn7	St14^tm2Bug/St14^tm3Bug Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * FVB	MGI:4361220
cn8	St14^tm2Bug/St14^tm3Bug Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss	MGI:5634327
cn9	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0 Tg(MMTV-Erbb2)1Pv/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N	MGI:4948967
cn10	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:4948966
cn11	Esr1^tm1Sakh/Esr1^tm1Sakh Tg(MMTV-cre)4Mam/?	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:4459316
cn12	Stat3^tm1Dlv/Stat3^tm1Dlv Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * C57BL/6J * FVB	MGI:4843432
cn13	Ep300^tm2Pkb/Ep300^tm2Pkb Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * FVB	MGI:3618540
cn14	Chuk^tm1Yhu/Chuk^tm1Yhu Tg(MMTV-cre)4Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB	MGI:3817625
cn15	Rlim^tm1.1Inba/Rlim^tm1.1Inba Tg(MMTV-cre)4Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB	MGI:4838163
cn16	Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Tg(MMTV-cre)4Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB	MGI:5517429
cn17	Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(MMTV-cre)4Mam/0	involves: 129S1/Sv * C57BL/6 * FVB	MGI:5306660
cn18	Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)4Mam/0	involves: 129S4/SvJae * FVB	MGI:4829793
cn19	Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(MMTV-cre)4Mam/0	involves: 129S4/SvJae * FVB	MGI:3617392
cn20	Kras^tm4Tyj/Kras⁺ Tg(MMTV-cre)4Mam/0	involves: 129S4/SvJae * FVB	MGI:3044680
cn21	Brca1^tm2Cxd/Brca1^tm2Cxd Pkm^tm1.1Mgvh/Pkm^tm1.1Mgvh Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)4Mam/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N	MGI:5547937
cn22	Brca1^tm1Cxd/Brca1^tm2Cxd Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB	MGI:2176786
cn23	Brca1^tm2Cxd/Brca1^tm2Cxd Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB	MGI:5297134
cn24	Brca1^tm2Cxd/Brca1^tm2Cxd Tg(MMTV-cre)4Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Esr1)#Paf/0 Trp53^tm1Brd/Trp53⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB	MGI:5297135
cn25	Brca1^tm1Cxd/Brca1^tm2Cxd Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * Black Swiss * FVB	MGI:2176785
cn26	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * Black Swiss * FVB	MGI:3055363
cn27	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * Black Swiss * FVB	MGI:3055366
cn28	Sav1^tm1.1Rjo/Sav1^tm1.1Rjo Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL	MGI:4430545
cn29	Brca1^tm2Cxd/Brca1^tm2Cxd Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * C57BL/6 * FVB	MGI:5297133
cn30	Mnt^tm1Awb/Mnt^tm1.1Awb Tg(MMTV-cre)4Mam/?	involves: 129S6/SvEvTac * FVB/N	MGI:3718675
cn31	Pparg^tm1Gonz/Pparg^tm1Gonz Tg(MMTV-cre)4Mam/?	involves: 129X1/SvJ * FVB	MGI:3722294
cn32	Ctnna1^tm1Efu/Ctnna1^tm1Efu Tg(MMTV-cre)4Mam/?	involves: 129X1/SvJ * FVB	MGI:3720649
cn33	Elf5^tm1Sin/Elf5^tm1Sin Tg(MMTV-cre)4Mam/0	involves: C57BL/6 * FVB	MGI:3844573
cn34	Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor⁺ Tg(MMTV-cre)4Mam/0	involves: C57BL/6J * C57BL/6N * FVB/N	MGI:5517430
cn35	Zmynd8^em1Lwb/Zmynd8^em1Lwb Tg(MMTV-cre)4Mam/0 Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6N * FVB	MGI:7432304
cn36	Mnt^tm1Phu/Mnt^tm1Phu Tg(MMTV-cre)4Mam/?	involves: FVB	MGI:2678344
tg37	Tg(MMTV-cre)4Mam/?	involves: FVB	MGI:4888635

Allelic Composition	Tg(CAG-Has2)99Nita/0 Tg(MMTV-cre)4Mam/0 Tg(MMTVneu)202Mul/0
Genetic Background	FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Has2)99Nita mutation (0 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTVneu)202Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:164205 )

increased mammary adenocarcinoma incidence ( J:130531 , J:164205 )

hematopoietic system

impaired macrophage chemotaxis ( J:164205 )

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

increased macrophage cell number ( J:164205 )

• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

immune system

impaired macrophage chemotaxis ( J:164205 )

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

increased macrophage cell number ( J:164205 )

• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

abnormal lymphatic vessel morphology ( J:130531 )

• mammary gland tumors express more podoplanin+ lymphatic endothelial cells than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice

• intratumoral lyphatics are 16-fold greater than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice while peritumoral lymphatic vessels are only 1.5-fold greater

• tumor lymphatic vessels are associated with high hyaluronan stroma

cellular

impaired macrophage chemotaxis ( J:164205 )

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:164205 )

increased mammary adenocarcinoma incidence ( J:130531 , J:164205 )

integument

increased mammary gland tumor incidence ( J:164205 )

increased mammary adenocarcinoma incidence ( J:130531 , J:164205 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:164205

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Crebbp^tm1Jvd/Crebbp^tm1Jvd Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (25 available)
Crebbp^tm1Jvd mutation (2 available); any Crebbp mutation (99 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:88323 )

• considerably accelerated tumor development

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:88323 )

• considerably accelerated tumor development

Allelic Composition	Crebbp^tm1Jvd/Crebbp^tm1Jvd Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129 * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbp^tm1Jvd mutation (2 available); any Crebbp mutation (99 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:88323 )

• decreased percentage of double positive cells

increased CD8-positive, alpha-beta T cell number ( J:88323 )

• increased percentage of CD8-SP thymocytes

neoplasm

increased T cell derived lymphoma incidence ( J:88323 )

• 59% of mice develop fatal T-cell lymphomas between 3 and 9 months of age

• remaining animals continue healthy past 10 months of age

hematopoietic system

decreased double-positive T cell number ( J:88323 )

• decreased percentage of double positive cells

increased CD8-positive, alpha-beta T cell number ( J:88323 )

• increased percentage of CD8-SP thymocytes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:88323 )

• 59% of mice develop fatal T-cell lymphomas between 3 and 9 months of age

• remaining animals continue healthy past 10 months of age

Allelic Composition	Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129 * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6v0a2^tm1Kdb mutation (0 available); any Atp6v0a2 mutation (52 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:274047 )

• glands from pubertal mice show delayed ductal outgrowth

impaired mammary gland growth during pregnancy ( J:274047 )

• early pregnant mammary glands show decreased ductal elongation, bifurcation and tertiary branching

abnormal mammary gland epithelium morphology ( J:274047 )

• mice and exhibit a disintegrated mammary epithelium, with a decrease in mammary epithelial content and in myoepithelial cells

abnormal mammary gland duct morphology ( J:274047 )

• at puberty, mice show a decrease in relative ductal length

• during early pregnancy, mice show decreased ductal elongation

abnormal branching of the mammary ductal tree ( J:274047 )

• early pregnant mammary glands show decreased bifurcation and tertiary branching

abnormal mammary duct terminal end bud morphology ( J:274047 )

• mice show a decrease in the number of terminal end buds and ductal branches

abnormal lactation ( J:274047 )

• mice exhibit a decrease in expression of beta-casein, a lactation marker, and litters from mutant mice have lower body weight than litters from wild-type mice, suggesting abnormal lactation

integument

abnormal mammary gland development ( J:274047 )

• glands from pubertal mice show delayed ductal outgrowth

impaired mammary gland growth during pregnancy ( J:274047 )

• early pregnant mammary glands show decreased ductal elongation, bifurcation and tertiary branching

abnormal mammary gland epithelium morphology ( J:274047 )

• mice and exhibit a disintegrated mammary epithelium, with a decrease in mammary epithelial content and in myoepithelial cells

abnormal mammary gland duct morphology ( J:274047 )

• at puberty, mice show a decrease in relative ductal length

• during early pregnancy, mice show decreased ductal elongation

abnormal branching of the mammary ductal tree ( J:274047 )

• early pregnant mammary glands show decreased bifurcation and tertiary branching

abnormal mammary duct terminal end bud morphology ( J:274047 )

• mice show a decrease in the number of terminal end buds and ductal branches

abnormal lactation ( J:274047 )

• mice exhibit a decrease in expression of beta-casein, a lactation marker, and litters from mutant mice have lower body weight than litters from wild-type mice, suggesting abnormal lactation

reproductive system

impaired mammary gland growth during pregnancy ( J:274047 )

• early pregnant mammary glands show decreased ductal elongation, bifurcation and tertiary branching

Allelic Composition	n-TUtca2^tm1Dhat/n-TUtca2^tm1Dhat Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129 * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TUtca2^tm1Dhat mutation (0 available); any n-TUtca2 mutation (2 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:82321 )

N	• normal mammary development and normal lactation

Allelic Composition	Mysm1^{tm1b(KOMP)Wtsi}/Mysm1^{tm1b(KOMP)Wtsi} Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129 * C57BL/6N * FVB/N
Cell Lines	EPD0019_1_A04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1^{tm1b(KOMP)Wtsi} mutation (0 available); any Mysm1 mutation (41 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased pro-B cell number ( J:179287 )

• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow

arrested B cell differentiation ( J:179287 )

• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells

abnormal T cell differentiation ( J:179287 )

• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal

abnormal common lymphocyte progenitor cell morphology ( J:179287 )

• most cells in the CLP population are Ly6D^- all-lymphoid progenitors with only a few Ly6D+ B cell biased lymphoid progenitors detected

decreased hematopoietic cell number ( J:179287 )

• absolute numbers of all hematopoietic cell lineages are reduced to varying degrees

• however the frequencies of CD3+ T and CD4+ T lymphocytes, Gr1+CD11b+ myeloid cells, Ter119+ erythrocytes, and CD41+Ter119^- megakaryocytes are largely normal or elevated in various tissues

decreased B cell number ( J:179287 )

• dramatic decrease in the percentage of B220+ CD19+ B cells in the bone marrow, spleen, peripheral blood, and lymph nodes compared to littermate controls

• marked reduction the number of peripheral B cells that express surface IgM and IgD mice have only 0.25% of control B cell numbers

decreased immature B cell number ( J:179287 )

• reduction in the number and frequency of pre-pro-B cells in the bone marrow

decreased pre-B cell number ( J:179287 )

• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow

pancytopenia ( J:179287 )

growth/size/body

postnatal growth retardation ( J:179287 )

limbs/digits/tail

short tail ( J:179287 )

• truncated tail

immune system

decreased pro-B cell number ( J:179287 )

• dramatic reduction in pro-B cell frequency and absolute numbers in bone marrow

arrested B cell differentiation ( J:179287 )

• in an in vitro pre-B cell colony forming assay no B cell colonies are formed from bone marrow cells

abnormal T cell differentiation ( J:179287 )

• the frequency of DN1 cells is increased and the frequency of DN2 cells is reduced; however, the frequencies of DP and DN cells are roughly equal

decreased B cell number ( J:179287 )

• dramatic decrease in the percentage of B220+ CD19+ B cells in the bone marrow, spleen, peripheral blood, and lymph nodes compared to littermate controls

• marked reduction the number of peripheral B cells that express surface IgM and IgD mice have only 0.25% of control B cell numbers

decreased immature B cell number ( J:179287 )

• reduction in the number and frequency of pre-pro-B cells in the bone marrow

decreased pre-B cell number ( J:179287 )

• dramatic reduction in pre-B cell frequency and absolute numbers in bone marrow

Allelic Composition	St14^tm2Bug/St14^tm3Bug Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St14^tm2Bug mutation (0 available); any St14 mutation (44 available)
St14^tm3Bug mutation (0 available); any St14 mutation (44 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:153070 )

N	• mice exhibit normal salivary gland morphology

decreased salivation ( J:153070 )

• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice

endocrine/exocrine glands

decreased salivation ( J:153070 )

• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice

homeostasis/metabolism

decreased salivation ( J:153070 )

• decreased pilocarpine-induced salivation compared with similarly treated wild-type mice

Allelic Composition	St14^tm2Bug/St14^tm3Bug Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

submandibular gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the submandibular gland

decreased salivation ( J:213072 )

• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

endocrine/exocrine glands

submandibular gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the submandibular gland

decreased salivation ( J:213072 )

• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

lacrimal gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the lacrimal gland

hematopoietic system

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• the percentage of CD25+Foxp3+ cells within the CD4+ T cell population is increased in the salivary gland draining lymph nodes

increased effector memory CD4-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD4-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD4+ cells among salivary gland draining lymph node cells and splenocytes

increased effector memory CD8-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD8-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD8+ cells among salivary gland draining lymph node cells and splenocytes

decreased regulatory T cell number ( J:213072 )

• total number of Treg cells in the salivary gland draining lymph node is decreased

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• decrease in the CD4+CD25+Foxp3+ Treg cell population in spleens

homeostasis/metabolism

decreased salivation ( J:213072 )

• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

immune system

submandibular gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the submandibular gland

lacrimal gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the lacrimal gland

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• the percentage of CD25+Foxp3+ cells within the CD4+ T cell population is increased in the salivary gland draining lymph nodes

increased effector memory CD4-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD4-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD4+ cells among salivary gland draining lymph node cells and splenocytes

increased effector memory CD8-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD8-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD8+ cells among salivary gland draining lymph node cells and splenocytes

decreased regulatory T cell number ( J:213072 )

• total number of Treg cells in the salivary gland draining lymph node is decreased

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• decrease in the CD4+CD25+Foxp3+ Treg cell population in spleens

abnormal cytokine secretion ( J:213072 )

• cytokine production is increased in local and systemic immune system

• mice exhibit an increase in IL-1beta, IL-4, IL-5, IL-, IL-10, IL-12-40, IL-13, IL-17, and IFN-gamma cytokines released from cells isolated from salivary gland salivary gland draining lymph node

• cultured splenocytes exhibit an increase in proinflammatory T/B cytokines and a decrease in the Th2 polarizing cytokine IL-4

• increase in proinflammatory cytokines is seen in the serum

abnormal chemokine secretion ( J:213072 )

• cultured splenocytes exhibit an increase in production of MCP-1, MCP-5, MIP-1beta, RANTES and MMP-9 chemokines

• increase in proinflammatory chemokines is seen in the serum

increased autoantibody level ( J:213072 )

• increase in serum levels of anti-SSA/Ro (multiple antigenic peptide (MAP)-Ro273), anti-SSB/La and anti-nuclear antibodies

increased anti-nuclear antigen antibody level ( J:213072 )

vision/eye

lacrimal gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the lacrimal gland

decreased tear production ( J:213072 )

• tear flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:213072

Allelic Composition	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0 Tg(MMTV-Erbb2)1Pv/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7^tm1.1Twad mutation (0 available); any Map2k7 mutation (19 available)
Map2k7^tm1.2Twad mutation (0 available); any Map2k7 mutation (19 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-Erbb2)1Pv mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170904 )

• compared with control mice

neoplasm

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

integument

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

mammary gland hyperplasia ( J:170904 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

mammary gland hyperplasia ( J:170904 )

Allelic Composition	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:170904 )

N	• mice exhibit normal mammary gland formation throughout puberty

Allelic Composition	Esr1^tm1Sakh/Esr1^tm1Sakh Tg(MMTV-cre)4Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1^tm1Sakh mutation (0 available); any Esr1 mutation (67 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:124962 )

• mammary ductal outgrowth arrested at prepubertal stage

• little ductal invasion of fat pad at 6 months

• minimal side branching

integument

abnormal branching of the mammary ductal tree ( J:124962 )

• mammary ductal outgrowth arrested at prepubertal stage

• little ductal invasion of fat pad at 6 months

• minimal side branching

Allelic Composition	Stat3^tm1Dlv/Stat3^tm1Dlv Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Dlv mutation (0 available); any Stat3 mutation (70 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T-helper 17 cell number ( J:120176 )

• reduction in the proportion of IL-17-producing T cells after polyclonally stimulated for 3 days in media alone or under optimal Th17 conditions in vitro

immune system

decreased T-helper 17 cell number ( J:120176 )

• reduction in the proportion of IL-17-producing T cells after polyclonally stimulated for 3 days in media alone or under optimal Th17 conditions in vitro

Allelic Composition	Ep300^tm2Pkb/Ep300^tm2Pkb Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300^tm2Pkb mutation (2 available); any Ep300 mutation (97 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:105505 )

N	• unexpectedly, no lymphomas developed for at least the first year of life

Allelic Composition	Chuk^tm1Yhu/Chuk^tm1Yhu Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin tumor incidence ( J:141162 )

• at 1 to 5 months of age, mice begin to develop skin tumors on their faces

integument

sparse hair ( J:141162 )

• 3 weeks after birth

epidermal hyperplasia ( J:141162 )

• in the dorsal epidermis

increased skin tumor incidence ( J:141162 )

• at 1 to 5 months of age, mice begin to develop skin tumors on their faces

Allelic Composition	Rlim^tm1.1Inba/Rlim^tm1.1Inba Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rlim^tm1.1Inba mutation (0 available); any Rlim mutation (16 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:165550 )

N	• male and female mice are born in normal Mendelian ratios

Allelic Composition	Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Jus mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal common lymphocyte progenitor cell morphology ( J:202090 )

• 20-fold increase

increased hematopoietic stem cell number ( J:202090 )

• expanded long term hematopoietic stem-like cells

Allelic Composition	Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1Jane mutation (1 available); any Grhl3 mutation (53 available)
Grhl3^tm3.1Jane mutation (1 available); any Grhl3 mutation (53 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:178952 )

• authors state that mice exhibit a phenotype identical to Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(KRT14-cre)8Brn mice

abnormal skin physiology ( J:178952 )

• authors state that mice exhibit a phenotype identical to Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(KRT14-cre)8Brn mice

neoplasm

increased tumor incidence ( J:178952 )

• authors state that mice exhibit a phenotype identical to Grhl3^tm1Jane/Grhl3^tm3.1Jane Tg(KRT14-cre)8Brn mice

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S4/SvJae * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:78415 )

• transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls

mammary gland duct hyperplasia ( J:78415 )

• transplants from virgins exhibit focal ductal hyperplasia containing papillary structure

• after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

integument

abnormal branching of the mammary ductal tree ( J:78415 )

• transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls

mammary gland duct hyperplasia ( J:78415 )

• transplants from virgins exhibit focal ductal hyperplasia containing papillary structure

• after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Cowden syndrome		DOID:6457	OMIM:PS158350	J:78415

Allelic Composition	Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S4/SvJae * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1^tm2Ggg mutation (1 available); any Pkd1 mutation (153 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney cyst ( J:103719 )

• 60% exhibit an occasional cyst on the surface of the kidney at 10 weeks of age and 100% have kidney cysts at 20 weeks of age

liver/biliary system

liver cyst ( J:103719 )

• 20% exhibit an occasional cyst on the surface of the liver at 10 weeks of age and 100% have multiple hepatic cysts at 20 weeks of age

growth/size/body

kidney cyst ( J:103719 )

• 60% exhibit an occasional cyst on the surface of the kidney at 10 weeks of age and 100% have kidney cysts at 20 weeks of age

liver cyst ( J:103719 )

• 20% exhibit an occasional cyst on the surface of the liver at 10 weeks of age and 100% have multiple hepatic cysts at 20 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic kidney disease 1		DOID:0110858	OMIM:173900	J:103719

Allelic Composition	Kras^tm4Tyj/Kras⁺ Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S4/SvJae * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

submandibular gland hyperplasia ( J:89333 )

• submandibular gland hyperplasia is seen in mutant mice

digestive/alimentary system

submandibular gland hyperplasia ( J:89333 )

• submandibular gland hyperplasia is seen in mutant mice

Allelic Composition	Brca1^tm2Cxd/Brca1^tm2Cxd Pkm^tm1.1Mgvh/Pkm^tm1.1Mgvh Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Pkm^tm1.1Mgvh mutation (2 available); any Pkm mutation (75 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:205213 )

• accelerated tumor associated mortality relative to control mice

neoplasm

increased mammary gland tumor incidence ( J:205213 )

• mice develop breast tumors similar to control mice

increased liver tumor incidence ( J:205213 )

• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice

increased metastatic potential ( J:205213 )

• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:205213 )

• mice develop breast tumors similar to control mice

integument

increased mammary gland tumor incidence ( J:205213 )

• mice develop breast tumors similar to control mice

liver/biliary system

increased liver tumor incidence ( J:205213 )

• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice

Allelic Composition	Brca1^tm1Cxd/Brca1^tm2Cxd Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Cxd mutation (1 available); any Brca1 mutation (113 available)
Brca1^tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:54533 )

• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:54533 )

• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

integument

increased mammary gland tumor incidence ( J:54533 )

• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
breast cancer	DOID:1612	OMIM:114480	J:54533
hereditary breast ovarian cancer syndrome	DOID:5683		J:54533

Allelic Composition	Brca1^tm2Cxd/Brca1^tm2Cxd Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased mammary gland epithelial cell proliferation ( J:132088 )

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen

mammary gland alveolar hyperplasia ( J:132088 )

• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to mutants with wild-type Trp53 and also an increase in the percentage of mice with hyperplastic alveolar nodules

increased mammary gland tumor incidence ( J:132088 )

• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

• cancers are Esr1-negative

neoplasm

increased mammary gland tumor incidence ( J:132088 )

• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

• cancers are Esr1-negative

preneoplasia ( J:132088 )

• mutants develop mammary gland preneoplasia that are Esr1-negative

renal/urinary system

ureter obstruction ( J:132088 )

• 25% of mutants develop ureteral obstruction 1-3 months after estrogen pellet placement

integument

increased mammary gland epithelial cell proliferation ( J:132088 )

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen

mammary gland alveolar hyperplasia ( J:132088 )

increased mammary gland tumor incidence ( J:132088 )

• 25% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

• cancers are Esr1-negative

cellular

increased mammary gland epithelial cell proliferation ( J:132088 )

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary breast ovarian cancer syndrome		DOID:5683		J:132088

Allelic Composition	Brca1^tm2Cxd/Brca1^tm2Cxd Tg(MMTV-cre)4Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Esr1)#Paf/0 Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Esr1)#Paf mutation (0 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:132088 )

• mutants develop hyperplastic alveolar nodules

increased mammary gland tumor incidence ( J:132088 )

• 100% of mutants develop invasive mammary cancer

• some cancers are Esr1-negative while others are Esr1-positive

neoplasm

increased mammary gland tumor incidence ( J:132088 )

• 100% of mutants develop invasive mammary cancer

• some cancers are Esr1-negative while others are Esr1-positive

preneoplasia ( J:132088 )

• mutants develop mammary gland preneoplasia

• some preneoplasia are Esr1-negative while others are Esr1-positive

integument

mammary gland alveolar hyperplasia ( J:132088 )

• mutants develop hyperplastic alveolar nodules

increased mammary gland tumor incidence ( J:132088 )

• 100% of mutants develop invasive mammary cancer

• some cancers are Esr1-negative while others are Esr1-positive

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary breast ovarian cancer syndrome		DOID:5683		J:132088

Allelic Composition	Brca1^tm1Cxd/Brca1^tm2Cxd Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal mammary gland growth during pregnancy ( J:54533 )

• at pregnancy day 8.5, mammary glands are smaller than controls

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

neoplasm

increased mammary gland tumor incidence ( J:54533 )

• 3 of 10 female mice developed mammary tumors of diverse types

increased mammary adenocarcinoma incidence ( J:54533 )

endocrine/exocrine glands

abnormal mammary gland development ( J:54533 )

• developmental defects may correlate with apoptosis observed in mutant mammary glands

abnormal branching of the mammary ductal tree ( J:54533 )

• abnormal ductal morphogenesis was observed at lactation and involution

abnormal involution of the mammary gland ( J:54533 )

• residual alveolar structures sometimes remain in involuting mammary glands

abnormal mammary gland growth during pregnancy ( J:54533 )

• at pregnancy day 8.5, mammary glands are smaller than controls

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

increased mammary gland tumor incidence ( J:54533 )

• 3 of 10 female mice developed mammary tumors of diverse types

increased mammary adenocarcinoma incidence ( J:54533 )

integument

abnormal mammary gland development ( J:54533 )

• developmental defects may correlate with apoptosis observed in mutant mammary glands

abnormal branching of the mammary ductal tree ( J:54533 )

• abnormal ductal morphogenesis was observed at lactation and involution

abnormal involution of the mammary gland ( J:54533 )

• residual alveolar structures sometimes remain in involuting mammary glands

abnormal mammary gland growth during pregnancy ( J:54533 )

• at pregnancy day 8.5, mammary glands are smaller than controls

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

increased mammary gland tumor incidence ( J:54533 )

• 3 of 10 female mice developed mammary tumors of diverse types

increased mammary adenocarcinoma incidence ( J:54533 )

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

integument

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

behavior/neurological

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

Allelic Composition	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

integument

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

behavior/neurological

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

Allelic Composition	Sav1^tm1.1Rjo/Sav1^tm1.1Rjo Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1^tm1.1Rjo mutation (0 available); any Sav1 mutation (19 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased liver tumor incidence ( J:156531 )

• by 14 months of age

liver/biliary system

increased liver tumor incidence ( J:156531 )

• by 14 months of age

Allelic Composition	Brca1^tm2Cxd/Brca1^tm2Cxd Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased mammary gland epithelial cell proliferation ( J:132088 )

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen

• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice

abnormal mammary gland duct morphology ( J:132088 )

• mammary glands exhibit longer ductal extension during puberty (6 weeks of age)

• 3 week old mutants exposed to continuous exogenous estrogen and progesterone for 2 weeks exhibit impaired terminal end bud differentiation into terminal ductal ends unlink wild-type mice

mammary gland alveolar hyperplasia ( J:132088 )

• mutants exposed to estrogen exhibit an increase in the number of hyperplastic alveolar nodules per mammary gland compared to controls and also an increase in the percentage of mice with hyperplastic alveolar nodules

increased mammary gland tumor incidence ( J:132088 )

• 14% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

integument

increased mammary gland epithelial cell proliferation ( J:132088 )

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen

• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice

abnormal mammary gland duct morphology ( J:132088 )

• mammary glands exhibit longer ductal extension during puberty (6 weeks of age)

• 3 week old mutants exposed to continuous exogenous estrogen and progesterone for 2 weeks exhibit impaired terminal end bud differentiation into terminal ductal ends unlink wild-type mice

mammary gland alveolar hyperplasia ( J:132088 )

increased mammary gland tumor incidence ( J:132088 )

• 14% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

renal/urinary system

ureter obstruction ( J:132088 )

• 71% of mutants develop ureteral obstruction 1-5 months after estrogen pellet placement

neoplasm

increased mammary gland tumor incidence ( J:132088 )

• 14% of mutants develop invasive mammary cancer when exposed to exogenous estrogen

cellular

increased mammary gland epithelial cell proliferation ( J:132088 )

• mutants exhibit increased mammary epithelial cellular proliferation compared to controls when treated with exogenous estrogen

• dense mammary epithelial cell growth is seen in estrogen-treated intact and ovariectomized mutants but not wild-type mice

Allelic Composition	Mnt^tm1Awb/Mnt^tm1.1Awb Tg(MMTV-cre)4Mam/?
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnt^tm1.1Awb mutation (0 available); any Mnt mutation (26 available)
Mnt^tm1Awb mutation (1 available); any Mnt mutation (26 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:110115 )

• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion

• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes

• tumors display ductal enlargement that may or may not be pre-existing

endocrine/exocrine glands

abnormal mammary gland morphology ( J:110115 )

• involution is delayed at I2, I5, and I16

• apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice

• apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis

abnormal involution of the mammary gland ( J:110115 )

• during involution after weaning, mice display enlarged ducts

• after involution ducts remain enlarged

• nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice

increased mammary adenocarcinoma incidence ( J:110115 )

• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion

• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes

• tumors display ductal enlargement that may or may not be pre-existing

integument

abnormal mammary gland morphology ( J:110115 )

• involution is delayed at I2, I5, and I16

• apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice

• apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis

abnormal involution of the mammary gland ( J:110115 )

• during involution after weaning, mice display enlarged ducts

• after involution ducts remain enlarged

• nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice

increased mammary adenocarcinoma incidence ( J:110115 )

• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion

• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes

• tumors display ductal enlargement that may or may not be pre-existing

Allelic Composition	Pparg^tm1Gonz/Pparg^tm1Gonz Tg(MMTV-cre)4Mam/?
Genetic Background	involves: 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pparg^tm1Gonz mutation (0 available); any Pparg mutation (39 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:76553 )

N	• mice have normal mammary gland development

Allelic Composition	Ctnna1^tm1Efu/Ctnna1^tm1Efu Tg(MMTV-cre)4Mam/?
Genetic Background	involves: 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1^tm1Efu mutation (1 available); any Ctnna1 mutation (133 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland epithelium morphology ( J:87469 )

• mammary glands have reduced numbers of epithelial cells

• some epithelial cells remain condensed and disorganized without forming alveolar structures

• lumens are absent from clusters of epithelium

abnormal milk composition ( J:87469 )

• milk proteins are reduced

abnormal mammary gland epithelium physiology ( J:87469 )

• apoptosis in mammary epithelium is increased

increased mammary gland apoptosis ( J:87469 )

• apoptosis in mammary epithelium is increased

integument

abnormal mammary gland epithelium morphology ( J:87469 )

• mammary glands have reduced numbers of epithelial cells

• some epithelial cells remain condensed and disorganized without forming alveolar structures

• lumens are absent from clusters of epithelium

abnormal milk composition ( J:87469 )

• milk proteins are reduced

abnormal mammary gland epithelium physiology ( J:87469 )

• apoptosis in mammary epithelium is increased

increased mammary gland apoptosis ( J:87469 )

• apoptosis in mammary epithelium is increased

abnormal hair follicle development ( J:87469 )

• occasionally hair development is not on schedule

Allelic Composition	Elf5^tm1Sin/Elf5^tm1Sin Tg(MMTV-cre)4Mam/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5^tm1Sin mutation (0 available); any Elf5 mutation (19 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:148362 )

• the expected number of mice are born but very few survive, no time of lethality provided

endocrine/exocrine glands

abnormal mammary gland development ( J:148362 )

• surviving females display poorly developed mammary epithelial structures

abnormal lactation ( J:148362 )

• surviving females display severe lactation defects

integument

abnormal mammary gland development ( J:148362 )

• surviving females display poorly developed mammary epithelial structures

abnormal lactation ( J:148362 )

• surviving females display severe lactation defects

Allelic Composition	Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor⁺ Tg(MMTV-cre)4Mam/0
Genetic Background	involves: C57BL/6J * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Jus mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:202090 )

• median survival is 64 days

immune system

enlarged thymus ( J:202090 )

• in diseased mice

abnormal thymus physiology ( J:202090 )

• lymphoid infiltration in the thymus at 6 months

enlarged spleen ( J:202090 )

• in diseased mice

abnormal leukocyte morphology ( J:202090 )

• monomorphic, enlarged white blood cells with a high nuclear:chromatin ratio (consistent with leukemic blasts) at 6 months

decreased pro-B cell number ( J:202090 )

arrested B cell differentiation ( J:202090 )

• nearly all B cells are arrested in the early pro-B stage

decreased double-positive T cell number ( J:202090 )

• in the thymus

decreased B cell number ( J:202090 )

• in the spleen

decreased mature B cell number ( J:202090 )

decreased pre-B cell number ( J:202090 )

increased leukocyte cell number ( J:202090 )

• at 6 months

increased CD8-positive, alpha-beta T cell number ( J:202090 )

• in the thymus

increased single-positive T cell number ( J:202090 )

• immature single positive cells in the thymus

increased large unstained cell number ( J:202090 )

• large, unstained cells (abnormal blasts) in the peripheral blood at 6 months

intermingled spleen red and white pulp ( J:202090 )

• disrupted separation between white and red pulp by infiltrating lymphoblasts at 6 months

enlarged lymph nodes ( J:202090 )

• in diseased mice

increased inflammatory response ( J:202090 )

• lymphoid infiltration in the spleen, interstitial and perivascular space of the kidney, perivascular cuffs in the liver, meninges surrounding the brain, thymus, stomach and intestine at 6 months

intestinal inflammation ( J:202090 )

• lymphoid infiltration in the intestine at 6 months

stomach inflammation ( J:202090 )

• lymphoid infiltration in the stomach at 6 months

meningitis ( J:202090 )

• lymphoid infiltration in the meninges surrounding the brain at 6 months

liver inflammation ( J:202090 )

• lymphoid infiltration in the perivascular cuffs in the liver at 6 months

kidney inflammation ( J:202090 )

• lymphoid infiltration in the interstitial and perivascular space of the kidney at 6 months

digestive/alimentary system

intestinal inflammation ( J:202090 )

• lymphoid infiltration in the intestine at 6 months

stomach inflammation ( J:202090 )

• lymphoid infiltration in the stomach at 6 months

neoplasm

increased acute lymphoblastic leukemia incidence ( J:202090 )

• mice rapidly develop and succumb to acute leukemia

behavior/neurological

lethargy ( J:202090 )

growth/size/body

distended abdomen ( J:202090 )

• in diseased mice

enlarged kidney ( J:202090 )

• in diseased mice

enlarged liver ( J:202090 )

• in diseased mice

enlarged spleen ( J:202090 )

• in diseased mice

respiratory system

respiratory distress ( J:202090 )

liver/biliary system

enlarged liver ( J:202090 )

• in diseased mice

liver inflammation ( J:202090 )

• lymphoid infiltration in the perivascular cuffs in the liver at 6 months

nervous system

meningitis ( J:202090 )

• lymphoid infiltration in the meninges surrounding the brain at 6 months

renal/urinary system

enlarged kidney ( J:202090 )

• in diseased mice

kidney inflammation ( J:202090 )

• lymphoid infiltration in the interstitial and perivascular space of the kidney at 6 months

hematopoietic system

enlarged thymus ( J:202090 )

• in diseased mice

abnormal thymus physiology ( J:202090 )

• lymphoid infiltration in the thymus at 6 months

enlarged spleen ( J:202090 )

• in diseased mice

anemia ( J:202090 )

• slightly at 6 months

thrombocytopenia ( J:202090 )

• severely at 6 months

abnormal leukocyte morphology ( J:202090 )

• monomorphic, enlarged white blood cells with a high nuclear:chromatin ratio (consistent with leukemic blasts) at 6 months

decreased pro-B cell number ( J:202090 )

arrested B cell differentiation ( J:202090 )

• nearly all B cells are arrested in the early pro-B stage

decreased double-positive T cell number ( J:202090 )

• in the thymus

decreased B cell number ( J:202090 )

• in the spleen

decreased mature B cell number ( J:202090 )

decreased pre-B cell number ( J:202090 )

increased leukocyte cell number ( J:202090 )

• at 6 months

increased CD8-positive, alpha-beta T cell number ( J:202090 )

• in the thymus

increased single-positive T cell number ( J:202090 )

• immature single positive cells in the thymus

increased large unstained cell number ( J:202090 )

• large, unstained cells (abnormal blasts) in the peripheral blood at 6 months

intermingled spleen red and white pulp ( J:202090 )

• disrupted separation between white and red pulp by infiltrating lymphoblasts at 6 months

endocrine/exocrine glands

enlarged thymus ( J:202090 )

• in diseased mice

abnormal thymus physiology ( J:202090 )

• lymphoid infiltration in the thymus at 6 months

Allelic Composition	Zmynd8^em1Lwb/Zmynd8^em1Lwb Tg(MMTV-cre)4Mam/0 Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: C57BL/6N * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Zmynd8^em1Lwb mutation (0 available); any Zmynd8 mutation (503 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:326848 )

• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

integument

decreased mammary gland tumor incidence ( J:326848 )

• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:326848 )

• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

Allelic Composition	Mnt^tm1Phu/Mnt^tm1Phu Tg(MMTV-cre)4Mam/?
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnt^tm1Phu mutation (0 available); any Mnt mutation (26 available)
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:85481 )

• developed in 6 out of 10 females tested

• tumor latency ranged from 6 months to 20 months

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:85481 )

• developed in 6 out of 10 females tested

• tumor latency ranged from 6 months to 20 months

integument

increased mammary adenocarcinoma incidence ( J:85481 )

• developed in 6 out of 10 females tested

• tumor latency ranged from 6 months to 20 months

Allelic Composition	Tg(MMTV-cre)4Mam/?
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)4Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:168531 )

• mammary gland development checked at the end of lactation was highly variable among mice

• cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter was not initiated until about 3 weeks of age

• cre expression shows a high level of mosaicism initially but complete deletion was observed in older mice

integument

abnormal mammary gland growth during lactation ( J:168531 )

• mammary gland development checked at the end of lactation was highly variable among mice

• cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter was not initiated until about 3 weeks of age

• cre expression shows a high level of mosaicism initially but complete deletion was observed in older mice

cellular

maternal effect ( J:168531 )

• 81% of pups nursed by mothers carrying this transgene survive to weaning

• pups nursed by mothers carrying this transgene are smaller than those nursed by control mothers but not statistically

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