Mysm1^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Mysm1^{tm1b(KOMP)Wtsi}
• Name: myb-like, SWIRM and MPN domains 1; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5896989
• Synonyms: Mysm1^{tm1a(deltaMP)Wtsi}
• Gene: Mysm1 Location: Chr4:94830277-94867337 bp, - strand Genetic Position: Chr4, 43.34 cM
• Alliance: Mysm1^{tm1b(KOMP)Wtsi} page
• IMPC: Mysm1 gene page

Mutation origin

• Mutant Cell Line: EPD0019_1_A04
• Germline Transmission: Earliest citation of germline transmission: J:179287
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_st0
• Mutation details: The L1L2_st0 cassette was inserted at position 94860893 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 94861685. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). (J:179287)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mysm1 Mutation: 41 strains or lines available

References

• Original: J:179287 Jiang XX, et al., Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1. Immunity. 2011 Dec 23;35(6):883-96
• All: 5 reference(s)