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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tcf3
transcription factor 3
MGI:98510
52 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cd19tm1(cre)Cgn/\Cd19+
\Tcf3tm1Mbu/\Tcf3tm1.2Mbu
\Tg(Vav-BCL2)69Jad/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL 		decreased pre-B cell number J:137719
\Id1tm1Zhu/\Id1tm1Zhu
\Tcf3tm1Wein/\Tcf3tm1Wein
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 		abnormal thymus corticomedullary boundary morphology J:44278
absent B cells J:44278
arrested B cell differentiation J:44278
decreased lymphocyte cell number J:44278
increased T cell derived lymphoma incidence J:44278
intermingled spleen red and white pulp J:44278
neonatal lethality, incomplete penetrance J:44278
postnatal growth retardation J:44278
postnatal lethality, incomplete penetrance J:44278
\Id2tm1Yyk/\Id2tm1Yyk
\Tcf3tm1Cmu/\Tcf3+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		absent axillary lymph nodes J:125739
absent brachial lymph nodes J:125739
absent inguinal lymph nodes J:125739
decreased NK T cell number J:125739
\Id2tm1Yyk/\Id2tm1Yyk
\Tcf3tm1Cmu/\Tcf3tm1Cmu
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased B cell number J:125739
decreased NK T cell number J:125739
normal immune system phenotype J:125739
small lymph nodes J:125739
\Id3tm2.1Cmu/\Id3tm2.1Cmu
\Tcf3tm4Zhu/\Tcf3tm4Zhu
\Tg(Cd4-cre)1Cwi/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2 		decreased thymocyte number J:176462
normal immune system phenotype J:176462
\Ikzf1tm1.1(Pax5)Mbu/\Ikzf1+
\Tcf3tm1Mbu/\Tcf3tm1Mbu
\Commd10Tg(Vav1-icre)A2Kio/\Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca 		abnormal immunoglobulin heavy chain V(D)J recombination J:137719
normal immune system phenotype J:137719
\Pax1un/\Pax1+
\Tcf3tm1Cmu/\Tcf3tm1Cmu
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal renal/urinary system morphology J:103567
abnormal T cell differentiation J:103567
abnormal T cell subpopulation ratio J:103567
curly tail J:103567
infertility J:103567
open neural tube J:103567
postnatal lethality, incomplete penetrance J:103567
spina bifida J:103567
\Pax5tm3Mbu/\Pax5+
\Tcf3tm1(PBX1)Mlc/\Tcf3+
\Cd19tm1(cre)Cgn/\Cd19+
involves: 129P2/OlaHsd * C57BL/6 		abnormal pro-B cell morphology J:226241
arrested B cell differentiation J:226241
decreased immature B cell number J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
\Tcf3tm1(PBX1)Mlc/\Tcf3+
\Cd19tm1(cre)Cgn/\Cd19+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:226241
abnormal pro-B cell differentiation J:226241
abnormal pro-B cell morphology J:226241
anemia J:226241
arrested B cell differentiation J:226241
decreased B cell number J:226241
decreased immature B cell number J:226241
enlarged liver J:226241
enlarged lymph nodes J:226241
enlarged spleen J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
increased leukocyte cell number J:226241
thrombocytopenia J:226241
\Tcf3tm1(PBX1)Mlc/\Tcf3+
\Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * CBA/J 		anemia J:226241
arrested B cell differentiation J:226241
decreased B cell number J:226241
decreased immature B cell number J:226241
enlarged liver J:226241
enlarged lymph nodes J:226241
enlarged spleen J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
increased leukocyte cell number J:226241
thrombocytopenia J:226241
\Tcf3tm1(PBX1)Mlc/\Tcf3+
\Cd79atm1(cre)Reth/\Cd79a+
involves: BALB/c * C57BL/6 		anemia J:226241
arrested B cell differentiation J:226241
decreased B cell number J:226241
decreased immature B cell number J:226241
enlarged liver J:226241
enlarged lymph nodes J:226241
enlarged spleen J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
increased leukocyte cell number J:226241
thrombocytopenia J:226241
\Tcf3tm1(TCF3/HLF)Homy/\Tcf3+
\Tg(Emu-Zfp521)1Homy/0
\Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		increased leukemia incidence J:160392
premature death J:160392
\Tcf3tm1Xhsu/\Tcf3tm1Xhsu
\Tg(Lck-Stat5b*)1Mafa/0
involves: 129X1/SvJ * C57BL/6 * FVB/N 		increased B cell proliferation J:132669
\Tcf3tm4Zhu/\Tcf3tm4Zhu
\Tg(Lck-cre)#Zhu/0
\Tg(TcrAND)53Hed/0
involves: 129S4/SvJae * C57BL/6 * SJL 		normal immune system phenotype J:75746
normal neoplasm J:75746
\Tcf4tm1Zhu/\Tcf4+
\Tcf3tm1Wein/\Tcf3+
involves: 129P2/OlaHsd 		decreased pro-B cell number J:43324
postnatal growth retardation J:43324
postnatal lethality, incomplete penetrance J:43324
\Tcf4tm1Zhu/\Tcf4+
\Tcf3tm1Zhu/\Tcf3+
involves: 129P2/OlaHsd 		normal nervous system phenotype J:125313
\Tcf12tm1Zhu/\Tcf12+
\Tcf3tm1Wein/\Tcf3+
involves: 129S4/SvJaeSor 		decreased pro-B cell number J:43324
postnatal growth retardation J:43324
postnatal lethality, incomplete penetrance J:43324
\Tcf12tm1Zhu/\Tcf12+
\Tcf3tm4Zhu/\Tcf3tm4Zhu
\Tg(Lck-cre)#Zhu/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal T cell differentiation J:75746
increased double-negative T cell number J:75746
increased single-positive T cell number J:75746
\Tcf12tm3Zhu/\Tcf12tm3Zhu
\Tcf3tm4Zhu/\Tcf3tm4Zhu
\Tg(Cd4-cre)1Cwi/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		abnormal CD8-positive, alpha beta T cell morphology J:129171
abnormal T cell differentiation J:129171
decreased CD4-positive, alpha-beta T cell number J:129171
increased CD8-positive, alpha-beta T cell number J:129171
\Tcf12tm3Zhu/\Tcf12tm3Zhu
\Tcf3tm4Zhu/\Tcf3tm4Zhu
\Tg(Lck-cre)#Zhu/0
involves: 129S4/SvJae * C57BL/6 * SJL/J 		decreased double-positive T cell number J:129570
decreased T cell number J:129570
increased double-negative T cell number J:129570
increased T cell proliferation J:129570
thymus hypoplasia J:129570
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory