Tcf3^{tm1(TCF3/HLF)Homy}
Targeted Allele Detail

Summary

• Symbol: Tcf3^{tm1(TCF3/HLF)Homy}
• Name: transcription factor 3; targeted mutation 1, Hiroaki Honda
• MGI ID: MGI:4458115
• Synonyms: EHKI^Neo+
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^{tm1(TCF3/HLF)Homy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160392
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding regions of exon 2 and 3 were replaced with a floxed STOP cassette, human cDNA of a fusion between TCF3 and HLF, IRES-EGFP, and SV40 polyadenylation sequence. The fusion was identified in patients with t(17;19) B-lineage acute lymphoblastic leukemia (ALL). Cre mediated removal of the floxed STOP cassette is required to obtain expression of the fusion cDNA. (J:160392)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 48 strains or lines available

References

• Original: J:160392 Yamasaki N, et al., Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia. Oncogene. 2010 Apr 1;29(13):1963-75
• All: 1 reference(s)