Tg(Lck-Stat5b*)1Mafa
Transgene Detail

Summary

• Symbol: Tg(Lck-Stat5b*)1Mafa
• Name: transgene insertion 1, Michael A Farrar
• MGI ID: MGI:3776805
• Synonyms: CA-STAT5, STAT5b-CA
• Transgene: Tg(Lck-Stat5b*)1Mafa Location: unknown
• Alliance: Tg(Lck-Stat5b*)1Mafa page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The Lck promoter with the Emu enhancer drives expression of a cDNA encoding a constitutively active Stat5b with point mutations that result in replacement of histidine with arginine at position 299 and serine with phenylalanine at position 711. This mutation results in constitutive phosphorylation of tyrosine 699. (J:86610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86610 Burchill MA, et al., Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol. 2003 Dec 1;171(11):5853-64
• All: 30 reference(s)