Tcf3^tm1Xhsu
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm1Xhsu
• Name: transcription factor 3; targeted mutation 1, Xioa-Hong Sun
• MGI ID: MGI:3776793
• Synonyms: E2A^M
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm1Xhsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132669
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 13 was replaced with an exon 13 containing point mutations followed by a floxed neo cassette. The neo cassette was removed by germ-line, cre-meditated recombination. The point mutations in exon 13 occur in the MAPK sites and render the protein product resistant to Notch-induced degradation. (J:132669)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 48 strains or lines available

References

• Original: J:132669 Nie L, et al., Regulation of lymphocyte development by cell-type-specific interpretation of notch signals. Mol Cell Biol. 2008 Mar;28(6):2078-90
• All: 2 reference(s)