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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Jak2
Janus kinase 2
MGI:96629
104 phenotypes from 15 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Jak2m1Dlbr/Jak2+
involves: 129S1/SvImJ * C57BL/6J 		decreased erythrocyte cell number J:207740
normal hematopoietic system phenotype J:207740
increased megakaryocyte cell number J:207740
thrombocytosis J:207740
Jak2m1Dlbr/Jak2m1Dlbr
involves: 129S1/SvImJ * C57BL/6J 		anemia J:207740
lethality throughout fetal growth and development, complete penetrance J:207740
Jak2m1Dlbr/Jak2tm1Jni
involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J 		anemia J:207740
lethality throughout fetal growth and development, complete penetrance J:207740
Jak2tm1(JAK2)Argr/Jak2+
Tg(Mx1-cre)1Cgn/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal bone marrow cell morphology/development J:164539
abnormal common myeloid progenitor cell morphology J:164539
abnormal erythropoiesis J:164539
abnormal hematopoietic system physiology J:164539
abnormal megakaryocyte differentiation J:164539
anemia J:164539
decreased hematopoietic stem cell number J:164539
decreased leukocyte cell number J:164539
enlarged spleen J:164539
increased erythrocyte cell number J:164539
increased erythroid progenitor cell number J:164539
increased hematocrit J:164539
increased hemoglobin content J:164539
increased leukocyte cell number J:164539
increased megakaryocyte cell number J:164539
myelofibrosis J:164539
thrombocytosis J:164539
Jak2tm1(JAK2)Argr/Jak2+
Dppa3tm1(cre)Peli/Dppa3+
involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 		abnormal protein level J:233169
increased chronic myelocytic leukemia incidence J:233169
increased hematopoietic stem cell number J:233169
increased leukocyte cell number J:233169
increased spleen weight J:233169
thrombocytosis J:233169
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal blood coagulation J:257910
abnormal blood vessel morphology J:257910
abnormal cytokine level J:257910
abnormal erythrocyte morphology J:257910
abnormal thrombosis J:257910
enlarged spleen J:257910
extramedullary hematopoiesis J:257910
increased erythrocyte cell number J:257910
increased erythroid progenitor cell number J:257910
increased granulocyte number J:257910
increased heart rate J:257910
increased leukocyte cell number J:257910
increased megakaryocyte cell number J:257910
increased megakaryocyte progenitor cell number J:257910
increased neutrophil cell number J:257910
limb paralysis J:257910
premature death J:257910
reticulocytosis J:257910
tachypnea J:257910
thrombocytosis J:257910
Jak2tm1.1Ble/Jak2tm1.1Ble
involves: 129S6/SvEvTac * C57BL/6 		prenatal lethality, complete penetrance J:160883
Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
involves: 129S2/SvPas * C57BL/6 		abnormal bone marrow cell morphology/development J:163497
abnormal common myeloid progenitor cell morphology J:163497
abnormal erythrocyte morphology J:163497
abnormal spleen morphology J:163497
anisocytosis J:163497
decreased circulating iron level J:163497
decreased mean corpuscular volume J:163497
decreased spleen white pulp amount J:163497
enlarged spleen J:163497
extramedullary hematopoiesis J:163497
giant platelets J:163497
increased erythrocyte cell number J:163497
increased erythroid progenitor cell number J:163497
increased granulocyte number J:163497
increased hematocrit J:163497
increased leukocyte cell number J:163497
increased lymphocyte cell number J:163497
increased mean platelet volume J:163497
increased megakaryocyte cell number J:163497
increased monocyte cell number J:163497
increased spleen red pulp amount J:163497
microcytosis J:163497
poikilocytosis J:163497
polychromatophilia J:163497
premature death J:163497
thrombocytosis J:163497
Jak2tm1.1Kuw/Jak2tm1.1Kuw
involves: 129X1/SvJ 		abnormal erythropoiesis J:90883
prenatal lethality, complete penetrance J:90883
Jak2tm1.2Ble/Jak2+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal definitive hematopoiesis J:160883
abnormal erythropoiesis J:160883
abnormal hematopoietic system physiology J:160883
abnormal megakaryocyte morphology J:160883
abnormal spleen morphology J:160883
abnormal spleen red pulp morphology J:160883
enhanced megakaryocyte emperipolesis J:160883
enlarged spleen J:160883
extramedullary hematopoiesis J:160883
normal hematopoietic system phenotype J:160883
increased erythroid progenitor cell number J:160883
increased hematocrit J:160883
increased hemolymphoid system tumor incidence J:160883
increased leukocyte cell number J:160883
increased megakaryocyte cell number J:160883
premature death J:160883
Jak2tm1.2Ble/Jak2tm1.2Ble
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		prenatal lethality, complete penetrance J:160883
Jak2tm1Jni/Jak2+
involves: 129P2/OlaHsd 		decreased erythrocyte cell number J:207740
normal hematopoietic system phenotype J:207740
thrombocytosis J:207740
Jak2tm1Jni/Jak2tm1Jni
involves: 129P2/OlaHsd 		abnormal erythropoiesis J:47299
abnormal megakaryocyte differentiation J:47299
anemia J:207740
extramedullary hematopoiesis J:47299
lethality throughout fetal growth and development, complete penetrance J:207740
prenatal lethality, complete penetrance J:47299
Jak2tm1Kf/Jak2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal enzyme/coenzyme activity J:112700
normal hematopoietic system phenotype J:112700
Jak2tm1Kf/Jak2tm1Kf
involves: 129S1/Sv * 129X1/SvJ 		abnormal erythropoiesis J:112700
decreased embryo size J:112700
embryonic lethality, complete penetrance J:112700
Jak2tm1Kpf/Jak2tm1Kpf
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) 		absent common myeloid progenitor cells J:47298
anemia J:47298
embryonic lethality during organogenesis, complete penetrance J:47298
impaired hematopoiesis J:47298
Jak2tm1Kuw/Jak2tm1Kuw
involves: 129X1/SvJ 		no abnormal phenotype detected J:90883
Jak2tm1Kuw/Jak2tm1Kuw
Tg(Gnrh1-cre)35Awo/0
involves: 129X1/SvJ * CD-1 		abnormal estrous cycle J:167849
abnormal neuron physiology J:167849
decreased circulating luteinizing hormone level J:167849
decreased corpora lutea number J:167849
decreased litter size J:167849
decreased ovary weight J:167849
decreased ovulation rate J:167849
delayed estrous cycle J:167849
delayed female fertility J:167849
delayed sexual maturation J:167849
delayed vaginal opening J:167849
normal homeostasis/metabolism phenotype J:167849
normal nervous system phenotype J:167849
prolonged diestrus J:167849
prolonged metestrus J:167849
reduced female fertility J:167849
short proestrus J:167849
Jak2tm1Kuw/Jak2tm1Kuw
Tg(MMTV-cre)1Mam/0
involves: 129X1/SvJ * C57BL/6 * FVB 		abnormal mammary gland development J:90883
abnormal mammary gland growth during pregnancy J:90883
lactation failure J:90883
Jak2tm1Kuw/Jak2tm1Kuw
Tg(Wap-cre)11738Mam/0
involves: 129X1/SvJ * C57BL/6 * FVB 		abnormal mammary gland growth during lactation J:90883
Jak2tm1Mohi/Jak2+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal bone marrow cavity morphology J:183821
abnormal bone marrow cell morphology/development J:183821
abnormal common myeloid progenitor cell morphology J:183821
abnormal spleen red pulp morphology J:183821
abnormal spleen white pulp morphology J:183821
decreased B cell number J:183821
enlarged spleen J:183821
increased erythrocyte cell number J:183821
increased erythroid progenitor cell number J:183821
increased hematocrit J:183821
increased hematopoietic stem cell number J:183821
increased hemoglobin content J:183821
increased leukocyte cell number J:183821
increased megakaryocyte cell number J:183821
increased neutrophil cell number J:183821
increased spleen red pulp amount J:183821
increased spleen weight J:183821
microcytosis J:183821
myelofibrosis J:183821
myeloid hyperplasia J:183821
polycythemia J:183821
reticulocytosis J:183821
spleen fibrosis J:183821
thrombocytosis J:183821
Jak2tm1Mohi/Jak2tm1Mohi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal bone marrow cavity morphology J:183821
abnormal bone marrow cell morphology/development J:183821
abnormal common myeloid progenitor cell morphology J:183821
abnormal spleen red pulp morphology J:183821
abnormal spleen white pulp morphology J:183821
decreased B cell number J:183821
decreased bone marrow cell number J:183821
decreased spleen white pulp amount J:183821
enlarged spleen J:183821
increased erythrocyte cell number J:183821
increased erythroid progenitor cell number J:183821
increased hematocrit J:183821
increased hematopoietic stem cell number J:183821
increased hemoglobin content J:183821
increased leukocyte cell number J:183821
increased megakaryocyte cell number J:183821
increased neutrophil cell number J:183821
increased spleen red pulp amount J:183821
increased spleen weight J:183821
microcytosis J:183821
myelofibrosis J:183821
myeloid hyperplasia J:183821
polycythemia J:183821
reticulocytosis J:183821
spleen fibrosis J:183821
thrombocytosis J:183821
Jak2tm2.1Jlvl/Jak2+
Tg(Vav1-cre)#Cgp/0
involves: 129S2/SvPas * C57BL/6NTac 		abnormal bone marrow cell physiology J:202234
abnormal definitive hematopoiesis J:202234
abnormal myelopoiesis J:202234
decreased B cell number J:202234
decreased bone marrow cell number J:202234
decreased erythroblast number J:202234
enlarged spleen J:202234
extramedullary hematopoiesis J:202234
increased erythrocyte cell number J:202234
increased erythroid progenitor cell number J:202234
increased granulocyte number J:202234
increased hematocrit J:202234
increased hematopoietic stem cell number J:202234
increased hemoglobin content J:202234
increased leukocyte cell number J:202234
increased spleen weight J:202234
microcytosis J:202234
myelofibrosis J:202234
myeloid hyperplasia J:202234
reticulocytosis J:202234
spleen fibrosis J:202234
thrombocytosis J:202234
Jak2tm2.1Kpf/Jak2tm2.1Kpf
involves: 129P2/OlaHsd 		abnormal cell physiology J:207710
abnormal embryonic erythropoiesis J:207710
embryonic lethality during organogenesis, complete penetrance J:207710
pallor J:207710
small liver J:207710
Jak2tm2.2Jlvl/Jak2+
involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL 		enlarged spleen J:202234
increased leukocyte cell number J:202234
polycythemia J:202234
thrombocytosis J:202234
Tg(H2-Kb-Jak2*V617F)2Shmd/0
involves: C57BL/6 * DBA/2 		abnormal definitive hematopoiesis J:130189
abnormal megakaryocyte morphology J:130189
abnormal spleen morphology J:130189
anemia J:130189
decreased erythroblast number J:130189
decreased erythrocyte cell number J:130189
decreased erythroid progenitor cell number J:130189
decreased hematocrit J:130189
decreased hemoglobin content J:130189
enhanced megakaryocyte emperipolesis J:130189
enlarged spleen J:130189
giant platelets J:130189
increased compact bone thickness J:130189
increased leukocyte cell number J:130189
increased megakaryocyte cell number J:130189
increased neutrophil cell number J:130189
increased number of Howell-Jolly bodies J:130189
increased spleen red pulp amount J:130189
increased spleen weight J:130189
myelofibrosis J:130189
myeloid hyperplasia J:130189
polychromatophilia J:130189
spleen fibrosis J:130189
thrombocytosis J:130189
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory