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Tg(MMTV-cre)1Mam
Transgene Detail
Summary
Symbol: Tg(MMTV-cre)1Mam
Name: transgene insertion 1, Lothar Hennighausen
MGI ID: MGI:2176165
Synonyms: A1 line, A-line, CreA, MMTV-Cre, MMTV-CreA, MMTV Cre line A, MMTV-CrelineA
Transgene: Tg(MMTV-cre)1Mam  Location: unknown  
Alliance: Tg(MMTV-cre)1Mam page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(MMTV-cre)1Mam expression driven by 1 gene
 
Mutation detailsThis transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, the salivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. (J:67925, J:74366)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: MMTV (virus)
Summary of all recombinase alleles driven by MMTV.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-cre)1Mam
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This transgene is the A line. Line 4 (D) and line F were also produced.
References
Original:  J:67925 Wagner KU, et al., Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 1997 Nov 1;25(21):4323-30
All:  91 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
02/13/2024
MGI 6.23
The Jackson Laboratory