Jak2^{tm1(JAK2)Argr}
Targeted Allele Detail

Summary

• Symbol: Jak2^{tm1(JAK2)Argr}
• Name: Janus kinase 2; targeted mutation 1, Anthony R Green
• MGI ID: MGI:4836590
• Synonyms: JAK2^F, JAK2^V617F
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^{tm1(JAK2)Argr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164539
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo stop cassette and a modified human cDNA with nucleotide substitutions that results in the amino acid substitution of phenylalanine for valine at position 617 (V617F) were inserted into exon 2. (J:164539)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 57 strains or lines available

References

• Original: J:164539 Li J, et al., JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood. 2010 Sep 2;116(9):1528-38
• All: 10 reference(s)