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Jak2tm1Kuw
Targeted Allele Detail
Summary
Symbol: Jak2tm1Kuw
Name: Janus kinase 2; targeted mutation 1, Kay-Uwe Wagner
MGI ID: MGI:3045140
Synonyms: Jak2fl
Gene: Jak2  Location: Chr19:29229228-29290480 bp, + strand  Genetic Position: Chr19, 23.73 cM
Alliance: Jak2tm1Kuw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90883
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    The first coding exon (exon 2) was flanked by loxP sites. (J:90883)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Jak2tm1Kuw
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jak2 Mutation:  35 strains or lines available
References
Original:  J:90883 Wagner KU, et al., Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol Cell Biol. 2004 Jun;24(12):5510-20
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
02/13/2024
MGI 6.23
The Jackson Laboratory