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Jak2tm1.1Ble
Targeted Allele Detail
Summary
Symbol: Jak2tm1.1Ble
Name: Janus kinase 2; targeted mutation 1.1, Benjamin L Ebert
MGI ID: MGI:4818800
Synonyms: Jak2Fl
Gene: Jak2  Location: Chr19:29229228-29290480 bp, + strand  Genetic Position: Chr19, 23.73 cM
Alliance: Jak2tm1.1Ble page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160883
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 14 and a cassette, consisting of a loxP511 site, a linker, an inverted loxP site, an inverted exon 14 containing a G1849T mutation, an inverted loxP511 site, and an FRT flanked neo selection cassette, was inserted downstream of exon 14 via homologous recombination. The neo cassette was removed by flp mediated recombination. The targeting cassette appears to interfere with endogenous gene expression making this a null allele. (J:160883)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jak2 Mutation:  57 strains or lines available
References
Original:  J:160883 Mullally A, et al., Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell. 2010 Jun 15;17(6):584-96
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory