89 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Airetm1.1Doi/Airetm1.1Doi H2b/H2b NOD.Cg-Airetm1.1Doi H2b/Doi	abnormal pancreas physiology	J:107432
	stomach inflammation	J:107432
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s H2b/H2b involves: A.BY * C57BL/6	abnormal immunoglobulin level	J:138778
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s H2b/H2d involves: BALB/c * C57BL/6	abnormal immunoglobulin level	J:138778
	increased susceptibility to Retroviridae infection	J:138778
	increased susceptibility to Retroviridae infection induced morbidity/mortality	J:138778
Dh/Dh+ H2d/H2d NZB.Cg-Dh	absent spleen	J:12036
	cryptorchism	J:12036
	decreased B cell proliferation	J:12036
	decreased IgG1 level	J:12036
	decreased IgG level	J:12036
	decreased IgM level	J:12036
	decreased lymphoma incidence	J:12036
	decreased susceptibility to graft versus host disease	J:12036
	glomerulonephritis	J:12036
	increased anti-erythrocyte antigen antibody level	J:12036
	increased anti-nuclear antigen antibody level	J:12036
	increased anti-single stranded DNA antibody level	J:12036
	increased autoantibody level	J:12036
	increased T cell proliferation	J:12036
	polyphalangy	J:12036
	reduced female fertility	J:12036
	reduced fertility	J:12036
H2b/H2b Itktm1Ljb/Itktm1Ljb Tg(TcrAND)53Hed/? involves: C3H/HeJ * C57BL/6 * C57BL/10	abnormal positive T cell selection	J:123795
	decreased CD4-positive, alpha-beta T cell number	J:123795
H2b/H2b Nfkbidtm1Clay/Nfkbidtm1Clay Rag2tm1Fwa/Rag2tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/? involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	abnormal thymocyte activation	J:132071
	decreased interleukin-2 secretion	J:132071
	decreased T cell proliferation	J:132071
H2b/H2b Ptcratm1Vbo/Ptcratm1Vbo involves: 129P2/OlaHsd	decreased double-positive T cell number	J:131357
	decreased thymocyte number	J:131357
	spleen hypoplasia	J:131357
H2b/H2b Ptcratm1Vbo/Ptcratm1Vbo Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/? involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal T cell differentiation	J:131357
	decreased thymocyte number	J:131357
H2b/H2b Ptcratm1Vbo/Ptcratm1Vbo Tg(TcraH-Y,TcrbH-Y)71Vbo/? involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal T cell differentiation	J:131357
H2b/H2b Rag1tm1Mom/Rag1tm1Mom Tg(Tcra19,Tcrb19)#Stl/0 involves: 129S7/SvEvBrd * C57BL/6	normal immune system phenotype	J:19795
H2b/H2b Rag2tm1Fwa/Rag2tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/? involves: 129S/SvEv * C57BL/6	abnormal cytotoxic T cell physiology	J:133112
	arrested T cell differentiation	J:133112
	decreased CD4-positive, alpha-beta T cell number	J:133112
	increased CD8-positive, alpha-beta T cell number	J:133112
	increased T cell proliferation	J:133112
H2b/H2b Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/? involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal negative T cell selection	J:81564
	abnormal T cell differentiation	J:81564
H2b/H2b Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/? involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal negative T cell selection	J:81564
	abnormal T cell differentiation	J:81564
H2b/H2b Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/? involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal double-negative T cell morphology	J:131357
	abnormal double-positive T cell morphology	J:81564
	abnormal negative T cell selection	J:81564
	abnormal T cell differentiation	J:81564
	decreased double-positive T cell number	J:131357
	decreased thymocyte number	J:131357
H2b/H2d Tg(Ins2-E3)1Dvs/0 involves: BALB/c * C57BL/6 * DBA/2J	increased length of allograft survival	J:109763
H2b/H2d Tg(TcraTcrb)1100Mjb/? involves: BALB/c * C57BL/6	abnormal negative T cell selection	J:133645
	decreased CD8-positive, alpha-beta T cell number	J:133645
	small thymus	J:133645
H2b/H2d Themistm1Gasc/Themistm1Gasc involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2	abnormal negative T cell selection	J:151074
H2b/H2g7 Tg(TcraR28,TcrbR28)KRNDim/0 involves: C57BL/6 * NOD * SJL	abnormal mitral valve morphology	J:275827
	increased hydroxyproline level	J:275827
	mitral valve inflammation	J:275827
	rheumatoid arthritis	J:36815, J:275827
	thick mitral valve	J:275827
H2b/H2k Itktm1Ljb/Itktm1Ljb Tg(TcrAND)53Hed/? involves: C3H/HeJ * C57BL/6 * C57BL/10	abnormal positive T cell selection	J:123795
	decreased CD4-positive, alpha-beta T cell number	J:123795
H2b/H2k Tg(TcraTcrb)1100Mjb/? involves: C57BL/6 * C57BL/10Sg * C57BR/c	abnormal negative T cell selection	J:133645
	decreased CD8-positive, alpha-beta T cell number	J:133645
	small thymus	J:133645
H2b/H2s Tg(TcraTcrb)1100Mjb/? involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss	abnormal negative T cell selection	J:133645
	decreased CD8-positive, alpha-beta T cell number	J:133645
	small thymus	J:133645
H2d/H2d Rag2tm1Fwa/Rag2tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/? involves: 129S/SvEv * C57BL/6	arrested T cell differentiation	J:133112
	decreased CD4-positive, alpha-beta T cell number	J:133112
	decreased CD8-positive, alpha-beta T cell number	J:133112
H2d/H2d Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/0 involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal T cell differentiation	J:131357
	decreased thymocyte number	J:131357
H2d/H2d Tg(TcraP1.5,TcrbP1.5)29Amsv/0 Trap1atm1.1Jvde/Y involves: 129 * BALB/cJ * C57BL/10 * DBA/2	abnormal T cell clonal deletion	J:180807
H2d/H2d Trap1atm1.1Jvde/Y involves: 129 * BALB/cJ * C57BL/10 * DBA/2	abnormal CD8-positive, alpha-beta T cell physiology	J:180807
	abnormal immune tolerance	J:180807
	decreased susceptibility to induced morbidity/mortality	J:180807
	normal reproductive system phenotype	J:180807
	tumor regression	J:180807
H2d/H2d Trap1atm1.1Jvde/Trap1atm1.1Jvde involves: 129 * BALB/cJ * C57BL/10 * DBA/2	normal reproductive system phenotype	J:180807
H2dlAb1-Ea/H2dlAb1-Ea Marchf1tm1.1Sish/Marchf1tm1.1Sish involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	normal immune system phenotype	J:157516
H2dlAb1-Ea/H2dlAb1-Ea Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog involves: 129S2/SvPas * C57BL/6	abnormal T cell differentiation	J:196156
	decreased CD8-positive, alpha-beta T cell number	J:196156
H2dlAb1-Ea/H2dlAb1-Ea Rag1tm1Mom/Rag1tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	brain inflammation	J:189816
H2dlAb1-Ea/H2dlAb1-Ea Rag1tm1Mom/Rag1tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	brain inflammation	J:189816
H2dlAb1-Ea/H2dlAb1-Ea Rr381em2Kap/Rr381em2Kap involves: 129S2/SvPas * C57BL/6	absent CD4-positive, alpha-beta T cells	J:333471
H2dlAb1-Ea/H2dlAb1-Ea Rr381em4Kap/Rr381em4Kap involves: 129S2/SvPas * C57BL/6	absent CD8-positive, alpha-beta T cells	J:333471
H2dlAb1-Ea/H2dlAb1-Ea Rr381em5Kap/Rr381em5Kap involves: 129S2/SvPas * C57BL/6	absent CD8-positive, alpha-beta T cells	J:333471
H2dlAb1-Ea/H2dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 involves: 129S2/SvPas * C57BL/6	normal nervous system phenotype	J:189816
H2dlAb1-Ea/H2dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas * C57BL/6	abnormal axon morphology	J:189816
	abnormal cytokine secretion	J:189816
	abnormal motor capabilities/coordination/movement	J:189816
	axon degeneration	J:189816
	brain inflammation	J:189816
	CNS inflammation	J:189816
	increased CD4-positive, alpha-beta T cell number	J:189816
	increased inflammatory response	J:189816
	increased interferon-gamma secretion	J:189816
	increased interleukin-17 secretion	J:189816
	increased susceptibility to experimental autoimmune encephalomyelitis	J:189816
	increased T-helper 1 cell number	J:189816
	increased T-helper 17 cell number	J:189816
	neuron degeneration	J:189816
H2dlAb1-Ea/H2dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas * C57BL/6	brain inflammation	J:189816
	increased susceptibility to experimental autoimmune encephalomyelitis	J:189816
H2dlAb1-Ea/H2dlAb1-Ea Tg(TRATL3A6,TRBTL3A6)#Kito/0 involves: 129S2/SvPas * C57BL/6	normal nervous system phenotype	J:189816
H2g7/H2g7 Ins2tm1Jja/Ins2tm1Jja Rag1tm1Mom/Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD	increased circulating glucose level	J:111874
	increased susceptibility to autoimmune diabetes	J:111874
H2g7/H2g7 Rag1tm1Mom/Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	increased susceptibility to autoimmune diabetes	J:111874
	insulitis	J:111874
H2g7/H2g7 Tg(Ins2-Vtcn1)#Xxz/0 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 involves: C57BL/6 * NOD * SJL	decreased interferon-gamma secretion	J:177612
	decreased interleukin-17 secretion	J:177612
	decreased regulatory T cell number	J:177612
	decreased susceptibility to autoimmune diabetes	J:177612
H2g7/H2g7 Tg(TcraAI4)1Dvs/0 Tg(TcrbAI4)1Dvs/0 B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs	increased susceptibility to autoimmune diabetes	J:167508
H2g7/H2g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 B6.Cg-H2g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi	decreased susceptibility to autoimmune diabetes	J:86926
H2g7/H2g7 Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	decreased susceptibility to autoimmune diabetes	J:111874
	insulitis	J:111874
H2g7/H2q Rag1tm1Mom/Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	increased susceptibility to autoimmune diabetes	J:111874
H2k/H2k Tg(TcraTcrbAD10)1Hed/? involves: C57BL/6 * SJL	increased CD4-positive, alpha-beta T cell number	J:124701
H2q/H2q Rag1tm1Mom/Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	decreased susceptibility to autoimmune diabetes	J:111874
	normal digestive/alimentary phenotype	J:111874
H2q/? Ncf1m1J/Ncf1m1J B6.Cg-Ncf1m1J H2q	decreased susceptibility to experimental autoimmune encephalomyelitis	J:92437
	increased susceptibility to experimental autoimmune encephalomyelitis	J:92437
	increased susceptibility to induced arthritis	J:92437
	increased susceptibility to type IV hypersensitivity reaction	J:92437
	rheumatoid arthritis	J:92437
H2u/H2u Rag1tm1Mom/Rag1tm1Mom Tg(Tcra19,Tcrb19)#Stl/0 either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J)	increased susceptibility to autoimmune disorder	J:19795
	limb paralysis	J:19795
H2u/H2u Tg(Tcra19,Tcrb19)#Stl/0 either: (involves: C57BL/6 * PL/J) or (involves: C57BL/6 * C57BL/10 * PL/J)	increased susceptibility to autoimmune disorder	J:19795
	increased susceptibility to experimental autoimmune encephalomyelitis	J:19795
H2u/H2u Tg(TCRA)B1Jg/0 B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J	abnormal thymus cell ratio	J:92992
	decreased CD4-positive, alpha-beta T cell number	J:92992
	decreased double-positive T cell number	J:92992
	decreased thymocyte number	J:92992
	increased double-negative T cell number	J:92992
	increased T cell derived lymphoma incidence	J:92992
H2u/H2u Tg(TCRA)B1Jg/0 Tg(TCRB)C14Jg/0 B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg Tg(TCRB)C14Jg	abnormal double-negative T cell morphology	J:92992
	abnormal double-positive T cell morphology	J:92992
	abnormal thymus cell ratio	J:92992
	absent gamma-delta T cells	J:92992
	decreased double-positive T cell number	J:92992
	increased CD4-positive, alpha-beta T cell number	J:92992
	increased double-negative T cell number	J:92992
	increased T cell derived lymphoma incidence	J:92992
H2u/H2u Tg(TCRA)B1Jg/? Tg(TCRB)C14Jg/? involves: C57BL/6 * C57BL/10SnSg * DBA/2 * PL/J	abnormal CD4-positive, alpha-beta T cell physiology	J:92991
	abnormal effector T cell morphology	J:92991
	decreased CD8-positive, alpha-beta T cell number	J:92991
	decreased double-positive T cell number	J:92991
	increased autoantibody level	J:92991
	increased CD4-positive, alpha-beta T cell number	J:92991
	increased susceptibility to experimental autoimmune encephalomyelitis	J:92991
	paralysis	J:92991
H2u/H2u Tg(TCRB)C14Jg/0 B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J	abnormal double-negative T cell morphology	J:92992
	abnormal double-positive T cell morphology	J:92992
	absent gamma-delta T cells	J:92992
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky H2b/H2b Tg(Tcrb)93Vbo/? involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal double-negative T cell morphology	J:131357
	abnormal double-positive T cell morphology	J:81564
	abnormal negative T cell selection	J:81564
	abnormal T cell differentiation	J:81564
	decreased double-positive T cell number	J:131357
	decreased thymocyte number	J:131357
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky H2d/H2d Ptcratm1Vbo/Ptcratm1Vbo Tg(Tcrb)93Vbo/? involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal T cell differentiation	J:131357
	decreased thymocyte number	J:131357