Apobec3^Gt(XN450)Byg
Gene trapped Allele Detail

Summary

• Symbol: Apobec3^Gt(XN450)Byg
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; gene trap XN450, BayGenomics
• MGI ID: MGI:3700142
• Synonyms: Apobec3^-, mA3^-
• Gene: Apobec3 Location: Chr15:79775860-79800107 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E2
• Alliance: Apobec3^Gt(XN450)Byg page

Mutation origin

• Mutant Cell Line: XN450
• Germline Transmission: Earliest citation of germline transmission: J:118597
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• A gene trap vector containing beta-gal was inserted into intron 4 of the locus. (J:118597)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XN450	CC326438 ; (MGI Seq Detail)	5' RACE	Chr15:79782324-79782423 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  87 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Apobec3 Mutation: 125 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:118597 Okeoma CM, et al., APOBEC3 inhibits mouse mammary tumour virus replication in vivo. Nature. 2007 Feb 22;445(7130):927-30
• All: 26 reference(s)