Marchf1^tm1.1Sish
Targeted Allele Detail

Summary

• Symbol: Marchf1^tm1.1Sish
• Name: membrane associated ring-CH-type finger 1; targeted mutation 1.1, Satoshi Ishido
• MGI ID: MGI:3706321
• Synonyms: March-1-KO
• Gene: Marchf1 Location: Chr8:66070552-66924289 bp, + strand Genetic Position: Chr8, 33.06 cM
• Alliance: Marchf1^tm1.1Sish page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119918
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 6, encoding the RINGv domain, was flanked by loxP sites and subsequently removed via cre-mediated recombination. Western blot confirmed absence of protein in mutants. (J:119918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Marchf1 Mutation: 36 strains or lines available

References

• Original: J:119918 Matsuki Y, et al., Novel regulation of MHC class II function in B cells. EMBO J. 2007 Feb 7;26(3):846-54
• All: 22 reference(s)