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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ebf1
early B cell factor 1
MGI:95275
75 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ebf1em1(IMPC)Mbp/Ebf1+
C57BL/6N-Ebf1em1(IMPC)Mbp/MbpMmucd 		abnormal heart morphology J:211773
abnormal liver morphology J:211773
abnormal lymph node morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
decreased prepulse inhibition J:211773
enlarged heart J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
increased circulating serum albumin level J:211773
increased startle reflex J:211773
no spontaneous movement J:211773
small heart J:211773
small spleen J:211773
Ebf1em1(IMPC)Mbp/Ebf1em1(IMPC)Mbp
C57BL/6N-Ebf1em1(IMPC)Mbp/MbpMmucd 		abnormal placenta morphology J:211773
no spontaneous movement J:211773
preweaning lethality, incomplete penetrance J:211773
Ebf1m1Btlr/Ebf1m1Btlr
C57BL/6J-Ebf1m1Btlr 		decreased B cell number J:265157
decreased IgD level J:265157
increased CD4-positive, alpha-beta T cell number J:265157
increased single-positive T cell number J:265157
increased T cell number J:265157
Ebf1m2Btlr/Ebf1m2Btlr
C57BL/6J-Ebf1m2Btlr 		abnormal humoral immune response J:265158
decreased B cell number J:265158
decreased B-1 B cell number J:265158
decreased B-2 B cell number J:265158
decreased IgD level J:265158
decreased IgM level J:265158
increased B-1a cell number J:265158
increased B-1b cell number J:265158
increased CD4-positive, alpha-beta T cell number J:265158
increased IgM level J:265158
increased single-positive T cell number J:265158
increased T cell number J:265158
increased tumor necrosis factor secretion J:265158
Ebf1M3Btlr/Ebf1M3Btlr
C57BL/6J-Ebf1M3Btlr 		decreased B-1 B cell number J:265160
increased CD4-positive, alpha-beta T cell number J:265160
increased single-positive T cell number J:265160
increased T cell number J:265160
Ebf1M4Btlr/Ebf1M4Btlr
C57BL/6J-Ebf1M4Btlr 		decreased B cell number J:267560
decreased NK cell number J:267560
increased alpha-beta T cell number J:267560
increased CD4-positive, alpha-beta T cell number J:267560
increased CD8-positive, alpha-beta T cell number J:267560
Ebf1M5Btlr/Ebf1M5Btlr
C57BL/6J-Ebf1M5Btlr 		abnormal lymphocyte morphology J:272841
decreased B cell number J:272841
decreased B-1 B cell number J:272841
Ebf1m6Btlr/Ebf1m6Btlr
C57BL/6J-Ebf1m6Btlr 		abnormal lymphocyte morphology J:272842
decreased B cell number J:272842
decreased B-1 B cell number J:272842
decreased effector memory CD4-positive, alpha-beta T cell number J:272842
decreased IgD level J:272842
increased alpha-beta T cell number J:272842
increased CD4-positive, alpha-beta T cell number J:272842
increased CD8-positive, alpha-beta T cell number J:272842
Ebf1tm1.1Rug/Ebf1tm1.1Rug
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		decreased B-1 B cell number J:182210
decreased marginal zone B cell number J:182210
Ebf1tm1.1Rug/Ebf1tm1.1Rug
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 * SJL 		arrested B cell differentiation J:182210
Ebf1tm1.1Rug/Ebf1tm1.1Rug
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		decreased germinal center B cell number J:182210
Ebf1tm1.1Rug/Ebf1tm1.1Rug
Polr2atm1(cre/ERT2)Bbd/Polr2a+
involves: C57BL/6 * SJL 		abnormal germinal center B cell physiology J:182210
arrested B cell differentiation J:182210
decreased B cell proliferation J:182210
decreased germinal center B cell number J:182210
decreased IgG1 level J:182210
decreased IgG3 level J:182210
decreased immature B cell number J:182210
decreased marginal zone B cell number J:182210
decreased pre-B cell number J:182210
decreased spleen germinal center number J:182210
decreased transitional stage B cell number J:182210
normal immune system phenotype J:182210
increased B cell apoptosis J:182210
increased B cell number J:182210
Ebf1tm1.1Rug/Ebf1tm1.1Rug
Tg(Cr2-cre)3Cgn/0
involves: C57BL/6 * SJL 		decreased B-1 B cell number J:182210
decreased marginal zone B cell number J:182210
Ebf1tm1Rug/Ebf1tm1Rug
involves: 129S2/SvPas 		abnormal B cell morphology J:52607
absent B-1 B cells J:52607
absent mature B cells J:52607
arrested B cell differentiation J:52607
decreased body size J:52607
decreased IgM level J:52607
decreased pro-B cell number J:52607
normal hematopoietic system phenotype J:52607
premature death J:52607
Ebf1tm1Rug/Ebf1tm1Rug
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal bone marrow morphology J:147179
abnormal bone ossification J:147179
abnormal bone structure J:147179
abnormal long bone epiphyseal plate morphology J:147179
abnormal trabecular bone morphology J:147179
decreased body size J:147179
decreased bone marrow cell number J:147179
decreased bone mineralization J:147179
decreased subcutaneous adipose tissue amount J:147179
delayed bone mineralization J:147179
hepatic steatosis J:147179
increased osteoblast cell number J:147179
increased osteoclast cell number J:147179
increased trabecular bone thickness J:147179
premature death J:147179
Ebf1tm1Rug/Ebf1tm1Rug
involves: 129S2/SvPas * C57BL/6 		abnormal anterior commissure pars posterior morphology J:44591
abnormal brain internal capsule morphology J:44591
abnormal lateral ganglionic eminence morphology J:44591
abnormal metencephalon morphology J:65601
abnormal striatum morphology J:44591
abnormal ventral striatum morphology J:44591
decreased striatum size J:44591
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory