Ebf1^tm1Rug
Targeted Allele Detail

Summary

• Symbol: Ebf1^tm1Rug
• Name: early B cell factor 1; targeted mutation 1, Rudolf Grosschedl
• MGI ID: MGI:1928729
• Synonyms: EBF-, Ebf1-, O/E-1^-
• Gene: Ebf1 Location: Chr11:44508144-44898918 bp, + strand Genetic Position: Chr11, 26.45 cM
• Alliance: Ebf1^tm1Rug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52607
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin cassette replaced exon 3, which encodes the DNA-binding domain. (J:52607)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	103 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebf1 Mutation: 73 strains or lines available

References

• Original: J:52607 Lin H, et al., Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature. 1995 Jul 20;376(6537):263-7
• All: 38 reference(s)