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Ebf1tm1Rug
Targeted Allele Detail
Summary
Symbol: Ebf1tm1Rug
Name: early B cell factor 1; targeted mutation 1, Rudolf Grosschedl
MGI ID: MGI:1928729
Synonyms: EBF-, Ebf1-, O/E-1-
Gene: Ebf1  Location: Chr11:44508144-44898918 bp, + strand  Genetic Position: Chr11, 26.45 cM
Alliance: Ebf1tm1Rug page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52607
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A PGK-neomycin cassette replaced exon 3, which encodes the DNA-binding domain. (J:52607)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 103 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 16 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ebf1 Mutation:  73 strains or lines available
References
Original:  J:52607 Lin H, et al., Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature. 1995 Jul 20;376(6537):263-7
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory