80 phenotypes from 16 alleles in 19 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19tm1(cre)Cgn/Cd19+ Ikbkbtm2Mka/Ikbkbtm2Mka involves: 129/Sv * 129P2/OlaHsd * C57BL/6	abnormal B cell activation	J:82995
	decreased B cell number	J:82995
	decreased B cell proliferation	J:82995
	decreased B-1 B cell number	J:82995
	decreased IgG level	J:82995
	decreased IgM level	J:82995
	decreased marginal zone B cell number	J:82995
	increased B cell apoptosis	J:82995
Cd19tm1(cre)Cgn/Cd19+ Ikbkbtm2Cgn/Ikbkbtm2.1Cgn involves: 129P2/OlaHsd * C57BL/6	decreased B-1 B cell number	J:79132
	decreased follicular B cell number	J:79132
	decreased marginal zone B cell number	J:79132
	decreased mature B cell number	J:79132
Cd19tm1(cre)Cgn/Cd19+ Ikbkbtm1Cgn/Ikbkbtm1.1Cgn involves: 129P2/OlaHsd * C57BL/6	decreased B-1 B cell number	J:79132
	decreased follicular B cell number	J:79132
	decreased immature B cell number	J:79132
	decreased marginal zone B cell number	J:79132
	decreased mature B cell number	J:79132
	increased B cell proliferation	J:79132
Cd19tm1(cre)Cgn/Cd19+ Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:113365
	abnormal splenic cell ratio	J:113365
	decreased B cell apoptosis	J:113365
	increased B cell number	J:113365
	increased cell proliferation	J:113365
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ Ikbkbtm1Lex/Ikbkbtm1Lex involves: 129S/SvEvBrd	abnormal fibroblast migration	J:159873
	decreased fibroblast cell migration	J:159873
	decreased fibroblast chemotaxis	J:159873
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+ Ighg1tm1(cre)Cgn/Ighg1+ involves: 129P2/OlaHsd * C57BL/6	abnormal spleen morphology	J:167612
	decreased germinal center B cell number	J:167612
	enlarged spleen	J:167612
	increased B cell number	J:167612
	increased IgG1 level	J:167612
	increased IgM level	J:167612
	increased plasma cell number	J:167612
Ikbkbem1Macc/Ikbkb+ involves: C57BL/6NCrl	abnormal effector T cell number	J:290616
	abnormal T cell activation	J:290616
	decreased B cell number	J:290616
	decreased CD4-positive, alpha-beta T cell number	J:290616
	decreased CD8-positive, alpha-beta T cell number	J:290616
	decreased memory B cell number	J:290616
	decreased T cell number	J:290616
	increased regulatory T cell number	J:290616
Ikbkbem1Macc/Ikbkbem1Macc involves: C57BL/6NCrl	abnormal effector T cell number	J:290616
	abnormal T cell activation	J:290616
	decreased B cell number	J:290616
	decreased CD4-positive, alpha-beta T cell number	J:290616
	decreased CD8-positive, alpha-beta T cell number	J:290616
	decreased memory B cell number	J:290616
	decreased T cell number	J:290616
	increased regulatory T cell number	J:290616
Ikbkbem1Smoc/Ikbkbem1Smoc C57BL/6J-Ikbkbem1Smoc	normal behavior/neurological phenotype	J:309163
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:309163
	normal embryo phenotype	J:309163
	normal reproductive system phenotype	J:309163
IkbkbM1Btlr/Ikbkb+ C57BL/6J-IkbkbM1Btlr	abnormal B cell physiology	J:225271
	abnormal CD8-positive, alpha-beta T cell differentiation	J:225271
	abnormal response to infection	J:225271
	increased response to antigen	J:225271
IkbkbM1Btlr/IkbkbM1Btlr C57BL/6J-IkbkbM1Btlr	abnormal B cell physiology	J:225271
	abnormal CD8-positive, alpha-beta T cell differentiation	J:225271
	increased susceptibility to viral infection	J:225271
IkbkbM2Btlr/IkbkbM2Btlr C57BL/6J-IkbkbM2Btlr	decreased central memory CD4-positive, alpha-beta T cell number	J:274802
Ikbkbtm1.1Cgn/Ikbkbtm1.1Cgn involves: C57BL/6	decreased interleukin-6 secretion	J:79132, J:85810
	increased fibroblast apoptosis	J:85810
	prenatal lethality, complete penetrance	J:85810
Ikbkbtm1a(EUCOMM)Wtsi/Ikbkb+ B6JTyr;B6N-Ikbkbtm1a(EUCOMM)Wtsi/Wtsi	decreased body weight	J:165965
	increased body weight	J:165965
Ikbkbtm1a(EUCOMM)Wtsi/Ikbkbtm1a(EUCOMM)Wtsi B6JTyr;B6N-Ikbkbtm1a(EUCOMM)Wtsi/Wtsi	preweaning lethality, incomplete penetrance	J:211773
Ikbkbtm1Cgn/Ikbkbtm1.1Cgn Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased CD8-positive, alpha-beta T cell number	J:85810
	decreased single-positive T cell number	J:85810
	decreased T cell number	J:85810
Ikbkbtm1Cgn/Ikbkbtm1Cgn involves: C57BL/6	no abnormal phenotype detected	J:85810
Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * DBA/2	psoriasis	J:208995
	skin inflammation	J:208995
Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(Lck-cre)I57Jxm/0 involves: C57BL/6 * ICR	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased CD8-positive, alpha-beta T cell number	J:85810
Ikbkbtm1Lex/Ikbkbtm1Lex Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * 129S/SvEvBrd	impaired macrophage chemotaxis	J:159873
	impaired neutrophil chemotaxis	J:159873
	impaired neutrophil recruitment	J:159873
Ikbkbtm1Mka/Ikbkbtm1Mka involves: 129S6/SvEvTac * C57BL/6	abnormal hepatocyte morphology	J:55737
	embryonic lethality during organogenesis, complete penetrance	J:55737
	liver degeneration	J:55737
Ikbkbtm1Trk/Ikbkbtm1Trk involves: 129S1/Sv * C57BL/6	abnormal cell physiology	J:55680
	abnormal hepatocyte morphology	J:55680
	increased fibroblast apoptosis	J:55680
	increased hepatocyte apoptosis	J:55680
	lethality throughout fetal growth and development, complete penetrance	J:55680
	liver degeneration	J:55680
Ikbkbtm1Ver/Ikbkbtm1Ver involves: 129S4/SvJae * C57BL/6J	abnormal cell physiology	J:54323
	dissociated hepatocytes	J:54323
	embryonic lethality during organogenesis, complete penetrance	J:54323
	increased fibroblast apoptosis	J:54323
	increased hepatocyte apoptosis	J:54323
	liver degeneration	J:54323
	liver hemorrhage	J:54323
	small liver	J:54323
Ikbkbtm2.1Cgn/Ikbkbtm2.1Cgn involves: C57BL/6	decreased interleukin-6 secretion	J:79132
Ikbkbtm2Cgn/Ikbkbtm2.1Cgn Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal humoral immune response	J:85810
	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased CD8-positive, alpha-beta T cell number	J:85810
	decreased IgE level	J:85810
Ikbkbtm2Cgn/Ikbkbtm2Cgn Tg(Alb1-cre)7Gsc/0 involves: C57BL/6 * FVB/N	abnormal enzyme/coenzyme activity	J:118336
	normal liver/biliary system phenotype	J:118336
Ikbkbtm2Cgn/Ikbkbtm2Cgn Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased memory T cell number	J:85810
	decreased regulatory T cell number	J:85810
Ikbkbtm2Mka/Ikbkbtm2.1Mka Tg(Vil-cre)1Mka/0 involves: 129	increased cellular sensitivity to gamma-irradiation	J:88644
	increased enterocyte apoptosis	J:88644
Ikbkbtm2Mka/Ikbkbtm2.1Mka Tg(Vil-cre)1Mka/0 involves: 129/Sv * C57BL/6	abnormal intestinal mucosa morphology	J:83313
	abnormal response to injury	J:83313
	decreased acute inflammation	J:83313
	decreased circulating tumor necrosis factor level	J:83313
	impaired neutrophil recruitment	J:83313
	intestinal edema	J:83313
Ikbkbtm2Mka/Ikbkbtm2Mka Lyz2tm1(cre)Ifo/Lyz2+ involves: 129/Sv * 129P2/OlaHsd	increased macrophage apoptosis	J:80159
Ikbkbtm2Mka/Ikbkbtm2Mka Tg(Ckmm-cre)1Lrsn/0 involves: 129	abnormal myotube morphology	J:135692
	increased skeletal muscle fiber number	J:135692