Ikbkb^tm2Mka
Targeted Allele Detail

Summary

• Symbol: Ikbkb^tm2Mka
• Name: inhibitor of kappaB kinase beta; targeted mutation 2, Michael Karin
• MGI ID: MGI:2445462
• Synonyms: Ikbk2^fx, IkkBeta^F, IKKBeta^fl, IKKbeta flox, Ikkbeta^loxP
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^tm2Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80159
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted that flank exon 3, which encodes the ATP binding site of the catalytic domain. An adjacent neomycin selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. (J:82995)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ikbkb^tm2Mka

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 54 strains or lines available

Notes

ES cell line = GS (Genome Systems).

References

• Original: J:80159 Park JM, et al., Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 2002 Sep 20;297(5589):2048-51
• All: 133 reference(s)