Ikbkb^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ikbkb^em1Smoc
• Name: inhibitor of kappaB kinase beta; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6758512
• Synonyms: Ikbkb^{tm1(Y397H)Smoc}
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting produced the amino acid substitution of tyrosine with histidine at position 397 (Y397H). (J:309163)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 54 strains or lines available

References

• Original: J:309163 Qin T, et al., A Novel Homozygous Mutation Destabilizes IKKbeta and Leads to Human Combined Immunodeficiency. Front Immunol. 2020;11:517544
• All: 1 reference(s)